How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes?

West, Allison; Zoni, Valeria; Teague, Walter E.; Leonard, Alison N.; Gawrisch, Klaus; Tristram-Nagle, Stephanie; Sachs, Jonathan N.; Klauda, Jeffery B.

doi:10.1021/acs.jpcb.9b08850

Cited by 27 publications

(21 citation statements)

References 94 publications

(175 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PC and PA or PG are randomly placed in a 3:1 molar ratio, PC and CL are in a 6:1 molar ratio, but one anionic lipid was placed near each of intermonomer groove. The CHARMM36m parameters were used for protein and lipids, TIP3P was for water (48, 49). The parameters for ions were taken from the previous report (50).…”

Section: Methodsmentioning

confidence: 99%

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

Inada

Iwamoto

Yoshida

et al. 2022

Preprint

View full text Add to dashboard Cite

Membrane proteins embedded in the membrane undergo changes in their actions under the influence of membrane lipids. Here, we present a novel type of lipid action on the potassium channel KcsA from Streptomyces lividans. Cardiolipin is present in various cellular membranes, including the host membrane of KcsA. Although the M0 domain, a non-transmembrane helix, is known to sense anionic lipids in the inner leaflet, we found that divalent anionic cardiolipin in the outer leaflet of the membrane interacts with positively charged residues, Arg64 and Arg89, on the extracellular side of the transmembrane domain. This binding propagates its action across the membrane toward the intracellular region of KcsA, thus, opening the inner gate. Such a long-range allosteric effect has not been found for channel-lipid interactions.

show abstract

Section: Methodsmentioning

confidence: 99%

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

Inada

Iwamoto

Yoshida

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The number of lipid molecules (128 total) was chosen based on recent reports. [65][66][67] Starting coordinates of the lipid bilayer, composed of 128 molecules of DMPC, were taken from the website of Biocomputing laboratory at the University of Calgary (http:// wcm.ucalgary.ca/tieleman/downloads) and solvated with 5227 water molecules in a rectangular box of 6.5 × 6.5 × 7.0 nm 3 . The mixed bilayers of DMPC and gemini components were obtained by a random selection of 52 molecules of DMPC replaced by the same number of gemini molecules.…”

Section: Methodsmentioning

confidence: 99%

How stereochemistry of lipid components can affect lipid organization and the route of liposome internalization into cells

Borocci

Bozzuto

Bombelli³

et al. 2021

Nanoscale

View full text Add to dashboard Cite

show abstract

“…However, with plasmalogen deficiency, the total amount of PUFAs in phosphatidylethanolamine remains constant in human fibroblasts and in the brains of mice. Plasmalogens have been noted to play an important role as neuroprotectors and modulators of the signaling mechanisms of cell membranes [ 85 ]. Plasmalogens also act as endogenous antioxidants, protecting lipids and lipoproteins from oxidative stress [ 86 ].…”

Section: Polyunsaturated Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

Lipid-Induced Mechanisms of Metabolic Syndrome

et al. 2020

View full text Add to dashboard Cite

Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.

show abstract

How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes?

Cited by 27 publications

References 94 publications

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

How stereochemistry of lipid components can affect lipid organization and the route of liposome internalization into cells

Lipid-Induced Mechanisms of Metabolic Syndrome

Contact Info

Product

Resources

About