How can anemia negatively influence gas exchange?

Ramos, Roberta Pulcheri

doi:10.1590/s1806-37562017000100001

Cited by 5 publications

(8 citation statements)

References 10 publications

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“…Despite the relatively small sample size and the lack of metabolic parameters of SCT carrier mice, we believe that our findings may pave the ground for further insights aimed at clarifying the molecular regulation of the endothelial response in SCT carriers. Furthermore, our results underpin the utility of the SCT carrier animal model for the study of the mechanisms by which vascular complications may occur in previously asymptomatic SCT carriers [ 11 , 12 , 13 , 14 , 15 ]. In this context, it should be considered that combined light microscopy and TEM analysis should be recommended to detect relevant microanatomical alterations.…”

Section: Discussionmentioning

confidence: 79%

“…On the other hand, heterozygous subjects (HBB A/S carriers of sickle cell trait—SCT) are virtually considered healthy subjects [ 8 , 9 , 10 ]. However, new clinical evidence is leading to a reconsideration of the importance and frequency of some complications observed in SCT carriers: exertion-related injury, chronic kidney disease (CKD), renal medullary carcinoma, thrombo-embolic diseases, and arteriopathies [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

Trucas

Burattini

Porcu

et al. 2023

IJMS

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Sickle cell disease (SCD) is caused by the homozygous beta-globin gene mutation that can lead to ischemic multi-organ damage and consequently reduce life expectancy. On the other hand, sickle cell trait (SCT), the heterozygous beta-globin gene mutation, is still considered a benign condition. Although the mechanisms are not well understood, clinical evidence has recently shown that specific pathological symptoms can also be recognized in SCT carriers. So far, there are still scant data regarding the morphological modifications referable to possible multi-organ damage in the SCT condition. Therefore, after genotypic and hematological characterization, by conventional light microscopy and transmission electron microscopy (TEM), we investigated the presence of tissue alterations in 13 heterozygous Townes mice, one of the best-known animal models that, up to now, was used only for the study of the homozygous condition. We found that endothelial alterations, as among which the thickening of vessel basal lamina, are ubiquitous in the lung, liver, kidney, and spleen of SCT carrier mice. The lung shows the most significant alterations, with a distortion of the general tissue architecture, while the heart is the least affected. Collectively, our findings contribute novel data to the histopathological modifications at microscopic and ultrastructural levels, underlying the heterozygous beta-globin gene mutation, and indicate the translational suitability of the Townes model to characterize the features of multiple organ involvement in the SCT carriers.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

Trucas

Burattini

Porcu

et al. 2023

IJMS

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“…A presença de hemoglobinopatias fora descartada pela presença de hemograma normal prévio (realizado no primeiro atendimento). A possibilidade de shunts cardíacos e pulmonares e as malformações arteriovenosas pulmonares também fora considerada Brazilian Journal of Health Review, Curitiba, v. 7, n. 3, p. 01-10, may/jun., 2024 improvável por sua história natural não ser condizente com a história clínica da paciente (Ramos, 2017).…”

Section: Relato Do Casounclassified

DRESS: um diagnóstico diferencial de insuficiência respiratória aguda infrequente

Passos,

Chaves,

Pacheco

et al. 2024

Braz. J. Hea. Rev.

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A insuficiência respiratória aguda (IRpA) é a incapacidade do sistema respiratório em manter a oxigenação e/ou ventilação resultando em falha no suprimento das demandas metabólicas do organismo com alterações na gasometria arterial como PaO2 < 60mmHg, PaCO2 >55mmHg e SatO2 <90%. A dispneia é o sintoma principal da IRpA, porém não é incomum que alguns pacientes com hipoxemia apresentem pouca ou nenhuma dispneia. Os principais sinais associados à redução da ventilação são o rebaixamento do nível de consciência, a respiração superficial, o uso de musculatura acessória da respiração; até, em última análise, os sinais de falência respiratória iminente como torpor, coma e a respiração paradoxal. Fisiopatologicamente, classificamos em Tipo I ou hipoxêmica aquelas decorrentes de alterações da troca gasosa e/ou do transporte de gases - sendo esta correspondente a maioria dos casos e o mecanismo envolvido no quadro do paciente deste relato - e tipo II ou hipercápnica ou ventilatória, a qual apresenta-se com alterações secundárias a geração e a transmissão do estímulo elétrico, a expansão da caixa torácica e a passagem do ar pelas vias aéreas (Rodrigues, 2022)

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“…Oxygen saturation (SaO 2 ) is the representative of percentage of oxygen occupied on the binding sites on haemoglobin [1]. Adequate oxygen delivery to organs depends on effective oxygen transport to the tissue mitochondria, a critical task that is performed by haemoglobin and this is greatly reduced in anaemic state [2]. Reduced oxygen saturation results in inadequate tissue supply, particularly when oxygen demand is increased, as occurs during exercise [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study

M. A.,

M. S.

et al. 2024

BMC Res Notes

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Objectives Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA. Results Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) participated in the study. The mean ± SD of age (years), oxygen saturation (%) and pulse rate (bpm) of participants with sickle cell anaemia and Hb AA control were 21.85 ± 3.04 and 22.14 ± 3.18 (t = 0.701, p = 0.436), 95.21 ± 3.02 and 98.07 ± 0.81 (t=-8.598, p < 0.0001) and 77.10 ± 9.28 and 73.16 ± 8.52 (t = 3.173, p = 0.002) respectively. The prevalence of hypoxemia among SCA participants was 47.1%. Prevalence of hypoxemia in males with SCA was 60.9% while 39.1% of the females had hypoxemia.

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How can anemia negatively influence gas exchange?

Cited by 5 publications

References 10 publications

Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

DRESS: um diagnóstico diferencial de insuficiência respiratória aguda infrequente

Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study

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