How brooding minds inhibit negative material: An event-related fMRI study

Vanderhasselt, Marie‐Anne; Baeken, Chris; Schuerbeek, Peter Van; Luypaert, Robert; Mey, Johan De; Raedt, Rudi De

doi:10.1016/j.bandc.2013.01.007

Cited by 34 publications

(31 citation statements)

References 48 publications

(36 reference statements)

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“…Given brooding refers to a tendency to maintain attention to negative stimuli (Joormann et al, 2006), high-brooders would tend to experience greater difficulties in disengaging from negative information, possibly due to lower efficiency of DLPFC functioning. Thus, among high-brooders, the left DLPFC may be recruited to greater extents to compensate for this inefficiency (Vanderhasselt et al, 2011, 2013; Wang et al, 2015), possibly through upregulating positive affective processing, which then gradually lead to increase in DLPFC structural volume (Draganski et al, 2004; Scholz et al, 2009; Wang et al, 2015). Failure to engage in this compensatory process could lead to greater affective dysregulation and more negative affective states, coupled with reduced DLPFC volume as observed in major depressive patients (Grieve et al, 2013; Lai, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with this, depressive patients show both DLPFC structural abnormalities and functional hypoactivity in resting-state and task-based fMRI (Gotlib and Hamilton, 2008; Koenigs and Grafman, 2009). Among healthy participants, in task-based fMRI, healthy subjects with high brooding tendency showed more DLPFC activations when trying to disengage from negative information compared to those with low brooding tendency (Vanderhasselt et al, 2011, 2013). Similarly, among major depressive patients, rumination induction elicited greater activations in the DLPFC than a distraction task (Cooney et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Greater activations in the rostral ACC (rACC) were found while participants were performing an emotional rather than cognitive stroop task (Mohanty et al, 2007). Further, when performing an emotion contrast task, dorsal ACC activity predicted individual differences in brooding score (Vanderhasselt et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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The Neuroanatomical Basis of Two Subcomponents of Rumination: A VBM Study

Sin

Shao

Geng

et al. 2018

Front. Hum. Neurosci.

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Rumination is a trait that includes two subcomponents, namely brooding and reflective pondering, respectively construed as maladaptive and adaptive response styles to negative experiences. Existing evidence indicates that rumination in general is associated with structural and functional differences in the anterior cingulate cortex (ACC) and the dorsal lateral prefrontal cortex (DLPFC). However, conclusive evidence on the specific neural structural basis of each of the two subcomponents is lacking. In this voxel-based morphometry study, we investigated the independent and specific neural structural basis of brooding and reflective pondering in 30 healthy young adults, who belonged to high or low brooding or reflective pondering groups. Consistent with past research, modest but significant positive correlation was found between brooding and reflective pondering. When controlling for reflective pondering, high-brooding group showed increased gray matter volumes in the left DLPFC and ACC. Further analysis on extracted gray matter values showed that gray matter of the same DLPFC and ACC regions also showed significant negative effects of reflective pondering. Taken together, our findings indicate that the two subcomponents of rumination might share some common processes yet also have distinct neural basis. In view of the significant roles of the left DLPFC and ACC in attention and self-related emotional processing/regulation, our findings provide insight into how the potentially shared and distinct cognitive, affective and neural processes of brooding and reflective pondering can be extended to clinical populations to further elucidate the neurobehavioral relationships between rumination and prefrontal abnormality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Neuroanatomical Basis of Two Subcomponents of Rumination: A VBM Study

Sin

Shao

Geng

et al. 2018

Front. Hum. Neurosci.

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“…Nevertheless, we observed a beneficial effect of tDCS on shift trials specifically in the emotion condition using (hypothesis driven) post hoc tests. Prior studies have shown that tDCS enhances WM for non-emotional information (e.g., Fregni et al, 2005) and cognitive processes for emotional information (e.g., Boggio et al, 2007;Vanderhasselt et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Nosce te ipsum – Socrates revisited? Controlling momentary ruminative self-referent thoughts by neuromodulation of emotional working memory

et al. 2013

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It becomes ever more evident that cognitive operations serve as fundamental mechanisms underlying higher order ruminative thoughts. In this sham controlled within subjects study, we performed anodal transcranial Direct Current Stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) in 32 healthy participants. We tested the causal hypothesis that the relationship between DLPFC activity and ruminative thinking is mediated by working memory operations. We used the Internal Shift Task, a paradigm in which participants have to update and shift between specific (non)emotional representations in working memory. These findings suggest that enhancing cognitive self-regulation, by increasing the ability to update and shift away from negative representations in working memory, might help individuals to control unintentional streams of self-referent thoughts that are self-critical and self-evaluative, a thinking style known as rumination.205 words 3

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“…Healthy individuals who tend to use reappraisal to overcome negative affect in daily life were behaviorally faster and exerted more dACC activity when inhibiting a response to negative in favor of positive information (compared to inhibiting a positive in favor of a negative response) (Vanderhasselt, Baeken, Van Schuerbeek, Luypaert, & De Raedt, 2013).…”

Section: A Cognitive Framework Of Depression and The Relationship Witmentioning

confidence: 98%

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

Raedt

Vanderhasselt

Baeken

2015

Clinical Psychology Review

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103

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Despite the fact that several interventions for major depression have proven efficacy, a substantial number of patients are or become treatment resistant to various forms of pharmacotherapy and psychotherapy. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but some of these interventions are unlikely to be easily accepted because of their more invasive nature or sideeffects. The efficacy of non-invasive neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficiently demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an overview of current neurostimulation approaches to treatment resistance and the introduction of a neurobiological and a cognitive framework of depression, we provide an integrative review of research on both the neurobiological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we describe our own studies and studies from other labs on new neurocognitive interventions. Finally we discuss how all this knowledge can be used to further develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions.

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How brooding minds inhibit negative material: An event-related fMRI study

Cited by 34 publications

References 48 publications

The Neuroanatomical Basis of Two Subcomponents of Rumination: A VBM Study

The Neuroanatomical Basis of Two Subcomponents of Rumination: A VBM Study

Nosce te ipsum – Socrates revisited? Controlling momentary ruminative self-referent thoughts by neuromodulation of emotional working memory

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

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