Nosce te ipsum – Socrates revisited? Controlling momentary ruminative self-referent thoughts by neuromodulation of emotional working memory

Vanderhasselt, Marie‐Anne; Brunoni, André R.; Loeys, Tom; Boggio, Paulo S.; Raedt, Rudi De

doi:10.1016/j.neuropsychologia.2013.08.011

Cited by 39 publications

(23 citation statements)

References 58 publications

(57 reference statements)

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“…This reference electrode location has been shown to be functionally ineffective in experimental designs (Nitsche et al, 2003). This electrodes placement and method of DLPFC localization is in accordance with prior tDCS studies (e.g., Giglia et al, 2014;Heinze et al 2014) and has demonstrated significant effects on cognitive information processing in previous research Vanderhasselt, Brunoni, Loeys, Boggio, & De Raedt, 2013). A constant, direct current of 2 mA, with 15 s of a ramp up and down, was applied for 20 min.…”

Section: Transcranial Direct Current Stimulation (Tdcs)supporting

confidence: 66%

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Sánchez

Vanderhasselt

Baeken

et al. 2016

Cogn Affect Behav Neurosci

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The aim of this study was to increase insight in the neural substrates of attention processes involved in emotion regulation. The effects of right dorsolateral prefrontal cortex (i.e., DLPFC) stimulation on attentional processing of emotional information were evaluated. A novel attention task allowing a straightforward measurement of attentional engagement toward, and attentional disengagement away from emotional faces was used. A sample of healthy participants received 20 minutes of active and sham anodal transcranial direct current stimulation (i.e., tDCS) applied over the right DLPFC on 2 separate days and completed the attention task after receiving real or sham stimulation. Compared to sham stimulation, tDCS over the right DLPFC led to impairments in attentional disengagement from both positive and negative faces. Findings demonstrate a causal role of right DLPFC activity in the generation of attentional impairments that are implicated in emotional disturbances such as depression and anxiety.

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Section: Transcranial Direct Current Stimulation (Tdcs)supporting

confidence: 66%

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Sánchez

Vanderhasselt

Baeken

et al. 2016

Cogn Affect Behav Neurosci

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“…Twenty minutes after neurostimulation, the occurrence of momentary self-referent ruminative thought was assessed during a rest period. The influence of tDCS (and not placebo) on ruminative thought was mediated by increased shifting ability away from negative to neutral information (Vanderhasselt, Brunoni, Loeys, Boggio & De Raedt, 2013). Although the task used in this study was not a training task but only a task to measure cognitive control, these findings in healthy individuals suggest that by training the ability to update and shift away from negative representations in working memory, combined with tDCS, might help patients to specifically control their ruminative thoughts.…”

Section: Cognitive Controlmentioning

confidence: 73%

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

Raedt

Vanderhasselt

Baeken

2015

Clinical Psychology Review

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102

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Despite the fact that several interventions for major depression have proven efficacy, a substantial number of patients are or become treatment resistant to various forms of pharmacotherapy and psychotherapy. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but some of these interventions are unlikely to be easily accepted because of their more invasive nature or sideeffects. The efficacy of non-invasive neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficiently demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an overview of current neurostimulation approaches to treatment resistance and the introduction of a neurobiological and a cognitive framework of depression, we provide an integrative review of research on both the neurobiological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we describe our own studies and studies from other labs on new neurocognitive interventions. Finally we discuss how all this knowledge can be used to further develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions.

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“…The dorsolateral prefrontal cortex (DLPFC) is one of the most frequently targeted stimulation sites in tDCS studies. Studies have shown that tDCS has modulatory effects on attention (Gladwin et al 2012b;Kang et al 2009;Kang et al 2012;Nelson et al 2014;Nozari and Thompson-Schill 2013), memory and verbal processing (Fertonani et al 2010;Fertonani et al 2014;Metuki et al 2012;Sela et al 2012;Vannorsdall et al 2012;Wirth et al 2011), and executive functioning (including working memory; Andrews et al 2011;Berryhill and Jones 2012;Boggio and Khoury 2009;Boggio et al 2006;Dockery et al 2009;Filmer et al 2013;Fregni et al 2005;Gladwin et al 2012a;Hammer and Mohammadi 2011;Harty et al 2014;Hoy et al 2014;Jo et al 2009;Keshvari et al 2013;Leite et al 2011;Leite et al 2013;Mulquiney and Hoy 2011;Penolazzi et al 2010;Plewnia et al 2013;Saidmanesh et al 2012;Vanderhasselt et al 2013a;Vanderhasselt et al 2013b;Wu et al 2014;Zmigrod et al 2014); for a meta-analysis of the effects of tDCS on working memory, see Brunoni and Vanderhasselt (2014), among others.…”

Section: Introductionmentioning

confidence: 99%

The effect of the interval-between-sessions on prefrontal transcranial direct current stimulation (tDCS) on cognitive outcomes: a systematic review and meta-analysis

et al. 2016

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Recently, there has been wide interest in the effects of transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) on cognitive functioning. However, many methodological questions remain unanswered. One of them is whether the time interval between active and sham-controlled stimulation sessions, i.e. the Interval Between Sessions (IBS), influences DLPFC tDCS effects on cognitive functioning.Therefore, a systematic review and meta-analysis was performed of experimental studies published in PubMed, Science Direct, and other databases from the first data available to February 2016. Single session shamcontrolled within-subject studies reporting the effects of tDCS of the DLPFC on cognitive functioning in healthy controls and neuropsychiatric patients were included. Cognitive tasks were categorized in tasks assessing memory, attention, and executive functioning. Evaluation of 188 trials showed that anodal vs. sham tDCS significantly decreased response times and increased accuracy, and specifically for the executive functioning tasks, in a sample of healthy participants and neuropsychiatric patients (although a slightly different pattern of improvement was found in analyses for both samples separately). The effects of cathodal vs. sham tDCS (45 trials), on the other hand, were not significant. IBS ranged from less than one hour to up to one week (i.e. cathodal tDCS) or two weeks (i.e. anodal tDCS). This IBS length had no influence on the estimated effect size when performing a meta-regression of IBS on reaction time and accuracy outcomes in all three cognitive categories, both for anodal and cathodal stimulation. Practical recommendations and limitations of the study are further discussed.

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Nosce te ipsum – Socrates revisited? Controlling momentary ruminative self-referent thoughts by neuromodulation of emotional working memory

Cited by 39 publications

References 58 publications

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

The effect of the interval-between-sessions on prefrontal transcranial direct current stimulation (tDCS) on cognitive outcomes: a systematic review and meta-analysis

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