How bone forms in large cancellous defects: Critical analysis based on experimental work and literature

Draenert, K.; Draenert, M.E.; Erler, M.; Draenert, A.; Draenert, Y.

doi:10.1016/j.injury.2011.06.007

Cited by 24 publications

(20 citation statements)

References 59 publications

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“…In that particular case, the inflammation was explained by sharp implant edges, which irritated surrounding soft tissues [656]. To avoid this, only rounded material should be used for implantation (Figure 15) [665]. Another reason for inflammation produced by porous HA could be due to micro movements of the implants, leading to simultaneous disruption of a large number of micro-vessels, which grow into the pores of the bioceramics.…”

Section: Biological Properties and In Vivo Behaviormentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

228

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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Section: Biological Properties and In Vivo Behaviormentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

228

153

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“…The Ca‐phosphate crystals have a close relationship to the periodic banding of type I collagen (Robinson and Watson, ). The tangential colonization through the osteoblasts is closely connected to the specific surface of calcium‐phosphate scaffolds (Draenert et al, ). The HA and β‐TCP implants in this study do not vary in their biocompatibility from the materials in other studies (De Long et al, ; Draenert et al, ; Eggli et al, ; Ferraro, ; Fujita et al, ; Jarcho et al, ; Moore et al, ; Schieker et al, ; Winter et al, ).…”

Section: Discussionmentioning

confidence: 99%

Section: Rationale and Objectivesmentioning

confidence: 99%

“…The physiological structure of the cancellous bone resembles more the structure of an eggshell, than trabeculae (Draenert et al, 2011;Weidenreich, 1922Weidenreich, , 1923Weidenreich, , 1930. Shell-formed ceramics, synthetically manufactured with variable interconnections, closely resemble young cancellous bone and, due to their large surface area, are completely overgrown from both sides like a sandwich (Draenert et al, 2011;Wiese, 1998). The indication of the highly nonreabsorbable HA with its higher compressive strength differs significantly from the indication (De Long et al, 2007;Draenert et al, 2011) of the more quickly resorbable b-tricalciumphosphate (TCP) implants (Bohner et al, 2005;Draenert et al, 2011;Eggli et al, 1988).…”

Section: Rationale and Objectivesmentioning

confidence: 99%

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Osseointegration of hydroxyapatite and remodeling‐resorption of tricalciumphosphate ceramics

Draenert

Draenert²,

Draenert³

2013

Microscopy Res & Technique

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In spite of osseointegration of HA and β-TCP, the osseointegration of both materials was completely different. Both shell-like bone void fillers were osseointegrated in a sandwich-like manner. HA yielded primarily a reinforcement of the recipient's cancellous-bone bed and full osseointegration after 4 months, whereas β-TCP-implants were fully osseointegrated after 6 weeks. HA did not show signs of resorption. The resorption of the β-TCP resulted during remodelling. The final stage showed restitution "ad integrum" of the β-TCP defects with a physiological architecture, whereas HA was integrated in the cancellous bone construction providing 600 μm measuring macropores showing osteoinductive properties.

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“…The bioactivity of β-TCP ceramics is well known from different animal studies and clinical evaluations [41,42], and the bone-forming element for a cancellous bone scaffold was considered to be the ceramic bead [43]. In combination with BMP-7, it was found that bone formation, remodelling and resorption are enhanced tremendously [15].…”

Section: Discussionmentioning

confidence: 99%

ε-Caprolactone in Micro-Chambered Ceramic Beads - A New Carrier for Gentamicin

Draenert

Hickel

Draenert³

2013

Chemotherapy

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Purpose: The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. Methods: The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied. Results and Discussion: Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts.

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How bone forms in large cancellous defects: Critical analysis based on experimental work and literature

Cited by 24 publications

References 59 publications

Calcium Orthophosphate-Based Bioceramics

Calcium Orthophosphate-Based Bioceramics

Osseointegration of hydroxyapatite and remodeling‐resorption of tricalciumphosphate ceramics

ε-Caprolactone in Micro-Chambered Ceramic Beads - A New Carrier for Gentamicin

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