How best to halt and/or revert UV-induced skin ageing: strategies, facts and fiction

Abstract

Once considered mainly a cosmetic issue, photoageing research has long moved to the forefront of investigative dermatology. Besides obvious market pressures, increasing insight into the mechanistic overlap between UV-induced skin cancer and UV-induced skin ageing has contributed to this development. Also, as strategies that work to antagonize intrinsic skin ageing/senescence may also be exploited against photoageing (and vice versa!), it has become an important skin research challenge to dissect both the differences and the overlap mechanisms between these interwined, yet distinct phenomena. Finally, the current surge in putative 'antiageing' products, devices, and strategies -too many of which

Identification of Matrix Metalloproteinase-1-Suppressive Peptides in Feather Keratin Hydrolysate

“…On the other hand, extrinsic aging (photoaging) is characterized by epidermal thickness, deep wrinkles, and elevated expression of MMPs. Long-term exposure to ultraviolet (UV) irradiation increases the expression of MMPs, concomitant with production of reactive oxygen species (ROS) in skin cells. − The ultraviolet B (UVB)-induced overexpression of MMPs in human fibroblasts and keratinocytes degrades the extracellular matrix (ECM), including the interstitial matrix and the basement membrane of the skin dermal layer . Given that expression of MMPs in the dermis is highly associated with extrinsic and intrinsic aging, inhibiting their expression and increasing the production of collagen represent promising therapeutic strategies for anti-skin aging.…”