How Bacterial Pathogens Coordinate Appetite with Virulence

Pokorzynski, Nick D.; Groisman, Eduardo A.

doi:10.1128/mmbr.00198-22

Cited by 3 publications

(1 citation statement)

References 408 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metabolism includes several components such as glycolysis, gluconeogenesis, citric acid cycle/tricarboxylic acid cycle (TCA), and pentose phosphate pathway (PPP) for carbon metabolism, nitrogen and sulfur metabolisms, and oxidative phosphorylation for energy production and nucleotide and AA metabolisms (Kanehisa and Goto 2000 , Kanehisa et al 2023 ). The link between metabolism and virulence was recently reviewed using S. enterica as a model (Pokorzynski and Groisman 2023 ). In this section, we propose to focus on some metabolic pathways required for bacterial survival into host blood.…”

Section: Bacterial Metabolic Factorsmentioning

confidence: 99%

Determinants of bacterial survival and proliferation in blood

Lê-Bury,

Echenique-Rivera,

Pizarro-Cerdá

et al. 2024

FEMS Microbiology Reviews

View full text Add to dashboard Cite

Bloodstream infection is a major public health concern associated with high mortality and high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention, diagnosis and management have been recognized as a global health priority by the World Health Organization. Additionally, infection control is increasingly threatened by antimicrobial resistance, which is the focus of global action plans in the framework of a One Health response. In-depth knowledge of the infection process is needed to develop efficient preventive and therapeutic measures. The pathogenesis of bloodstream infection is a dynamic process resulting from the invasion of the vascular system by bacteria, which finely regulate their metabolic pathways and virulence factors to overcome the blood immune defenses and proliferate. In this review, we highlight our current understanding of determinants of bacterial survival and proliferation in the bloodstream and discuss their interactions with the molecular and cellular components of blood.

show abstract

Section: Bacterial Metabolic Factorsmentioning

confidence: 99%

Determinants of bacterial survival and proliferation in blood

Lê-Bury,

Echenique-Rivera,

Pizarro-Cerdá

et al. 2024

FEMS Microbiology Reviews

View full text Add to dashboard Cite

show abstract

The pig intestinal phageome is an important reservoir and transfer vector for virulence genes

Ji,

Xi,

Chen

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

Mechanisms of host adaptation by bacterial pathogens

Barber,

Fitzgerald

2024

FEMS Microbiology Reviews

View full text Add to dashboard Cite

The emergence of new infectious diseases poses a major threat to humans, animals, and broader ecosystems. Defining factors that govern the ability of pathogens to adapt to new host species is therefore a crucial research imperative. Pathogenic bacteria are of particular concern given dwindling treatment options amid the continued expansion of antimicrobial resistance. In this review we summarize recent advancements in the understanding of bacterial host species adaptation, with an emphasis on pathogens of humans and related mammals. We focus particularly on molecular mechanisms underlying key steps of bacterial host adaptation including colonization, nutrient acquisition, and immune evasion, as well as suggest key areas for future investigation. By developing a greater understanding of the mechanism underlying host adaptation in pathogenic bacteria, we may uncover new strategies to target these microbes for the treatment and prevention of infectious diseases in humans, animals, and the broader environment.

show abstract

How Bacterial Pathogens Coordinate Appetite with Virulence

Abstract: Cells adjust growth and metabolism to nutrient availability. Having access to a variety of carbon sources during infection of their animal hosts, facultative intracellular pathogens must efficiently prioritize carbon utilization.

Cited by 3 publications

References 408 publications

Determinants of bacterial survival and proliferation in blood

Determinants of bacterial survival and proliferation in blood

The pig intestinal phageome is an important reservoir and transfer vector for virulence genes

Mechanisms of host adaptation by bacterial pathogens

Contact Info

Product

Resources

About