House dust mite-specific IgE antibodies in induced sputum are associated with sputum eosinophilia in mite-sensitive asthmatics

Nahm, Dong-Ho; Park, Hae‐Sim

doi:10.1016/s1081-1206(10)62452-0

Cited by 7 publications

(2 citation statements)

References 21 publications

(27 reference statements)

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“…Positive correlations between serum IgE and blood eosinophil count were also reported in children living in Northern Europe (21) in Kuwait (22) and in Indonesia (23). The deep involvement of IgE‐dependent mechanisms in the eosinophilic inflammation is further supported by the demonstration of high levels of allergen‐specific IgE in induced sputum of allergic asthmatic individuals, correlating with ECP (eosinophilic cationic protein) concentration (24).…”

Section: Discussionmentioning

confidence: 95%

Total and allergen‐specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites

Sacco

Sale

Silvestri

et al. 2003

Pediatric Allergy Immunology

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Although elevated levels of serum immunoglobulin E (IgE) are considered the hallmark of atopic diseases, their clinical value in evaluating subjects with allergic disorders is under debate. To evaluate possible relationships between serum IgE levels and a variety of clinical parameters, 83 mild asthmatic children [10.98-year-old (2.95)], sensitized to house dust mites (HDM) Dermatophagoides pteronyssinus (Dp) or D. farinae (Df), were enrolled. As compared with normal control reference values detected in our laboratory, children with allergic asthma had higher blood eosinophil counts (expressed both as percentage and as absolute number) and higher fractional exhaled nitric oxide (FeNO) levels but similar values in pulmonary function parameters. In the allergic asthmatic population, serum levels of total, Dp-specific or Df-specific IgE correlated positively with eosinophil counts (Rho > or = 0.30, p < 0.01, each correlation) and FeNO levels (Rho > or = 0.33, p < 0.01, each correlation) but not with pulmonary function parameters (p > 0.1, each correlation). Finally, significant correlations, although moderate, were found in the allergic asthmatic population between eosinophil counts and FeNO levels (Rho > or = 0.42, p < 0.001, each correlation). Thus, in atopic children sensitized to HDM with mild intermittent asthma, IgE levels in blood appear to reflect systemic (blood eosinophils) and organ-specific (FeNO) markers of allergic inflammation but not pulmonary volumes or the degree of airflow limitation.

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Section: Discussionmentioning

confidence: 95%

Total and allergen‐specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites

Sacco

Sale

Silvestri

et al. 2003

Pediatric Allergy Immunology

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“…The serum IgE concentration was measured using enzyme-linked immunosorbent assays as described previously [15,16]. Peripheral blood eosinophil, neutrophil, monocyte, and lymphocyte counts were measured using an automated hematology analyzer (Coulter Counter STKS; Beckman Coulter, Fullerton, Calif., USA).…”

Section: Methodsmentioning

confidence: 99%

Effects of Intramuscular Injection of Autologous Immunoglobulin on Clinical Severity and Serum IgE Concentration in Patients with Atopic Dermatitis

Nahm

Kim

Cho³

2015

Dermatology

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Background/Objective: The management of patients with atopic dermatitis (AD) is often difficult for both patients and physicians. We hypothesized that repeated intramuscular injections of autologous immunoglobulin can induce clinical improvement in patients with AD by correcting immune dysfunction. Methods: Seventeen adult patients with severe AD were treated by intramuscular injection of 50 mg autologous immunoglobulin (mainly IgG with a purity ≥97%) twice a week for 4 weeks. The standardized clinical severity scoring system for AD (SCORAD) value and serum IgE concentration were measured at baseline and at 4, 8, and 12 weeks. Results: SCORAD values and serum IgE concentrations significantly decreased at 4, 8, and 12 weeks compared to baseline (p < 0.05). No significant side effects were observed. Conclusions: Repeated intramuscular injections of autologous immunoglobulin significantly decreased the clinical severity and serum IgE concentration in patients with severe AD. Further studies are required to evaluate the clinical significance of these findings.

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Clinical Evaluation of Specific Immunoglobulin E in Sputum in Pediatric Patients

Young

Seok

2018

Pediatric Allergy, Immunology, and Pulmonology

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House dust mite-specific IgE antibodies in induced sputum are associated with sputum eosinophilia in mite-sensitive asthmatics

Cited by 7 publications

References 21 publications

Total and allergen‐specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites

Total and allergen‐specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites

Effects of Intramuscular Injection of Autologous Immunoglobulin on Clinical Severity and Serum IgE Concentration in Patients with Atopic Dermatitis

Clinical Evaluation of Specific Immunoglobulin E in Sputum in Pediatric Patients

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