House‐dust‐mite allergen concentrations (Der f 1) and mold spores in apartment bedrooms before and after installation of insulated windows and central heating systems

Hirsch, Thomas; Hering, Martin; Bürkner, K.; Hirsch, D.; Leupold, W; Kerkmann, M.-L.; Kuhlisch, Eberhard; Jatzwauk, Lutz

doi:10.1034/j.1398-9995.2000.00250.x

Cited by 50 publications

(40 citation statements)

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“…Its conidia production is prolific, and so human respiratory tract exposure is almost constant 4 . A. fumigatus is isolated from human habitats 5 and vegetable compost heaps 6,7 . In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref.…”

mentioning

confidence: 99%

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Nierman

Pain

Anderson

et al. 2005

Nature

1,255

936

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mentioning

confidence: 99%

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Nierman

Pain

Anderson

et al. 2005

Nature

1,255

936

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“…One study addressed changes in apartment bedrooms before and after installation of insulated windows and central heating in Dresden (Germany) [119]. Both house dust mite antigen and A. fumigatus concentrations increased after the installation, whereas other moulds remained unchanged.…”

Section: Indoor Mould Exposurementioning

confidence: 99%

The link between fungi and severe asthma: a summary of the evidence

Denning

O’Driscoll²,

Hogaboam³

et al. 2006

European Respiratory Journal

723

631

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There is current evidence to demonstrate a close association between fungal sensitisation and asthma severity. Whether such an association is causal remains to be confirmed, but this is explored by means of a detailed literature review. There is evidence from two randomised controlled trials that, in the example of allergic bronchopulmonary aspergillosis (ABPA), treatment with systemic antifungal therapy can offer a therapeutic benefit to ,60% of patients. ABPA is only diagnosed if a combination of clinical and immunological criteria is achieved. It is not known whether such cases are a discrete clinical entity or part of a spectrum of the pulmonary allergic response to fungi or fungal products.This paper describes the epidemiological evidence that associates severity of asthma with fungi and discusses possible pathogenetic mechanisms. Many airborne fungi are involved, including species of Alternaria, Aspergillus, Cladosporium and Penicillium, and exposure may be indoors, outdoors or both. The potential for a therapeutic role of antifungal agents for patients with severe asthma and fungal sensitisation is also explored.Not only are many patients with severe asthma desperately disabled by their disease, but, in the UK alone, asthma accounts for 1,500 deaths per yr. The healthcare costs of these patients are enormous and any treatment option merits close scrutiny. Within this report, the case for the consideration of a new term related to this association is put forward. The current authors propose the term ''severe asthma with fungal sensitisation''. However, it is recognised that enhanced and precise definition of fungal sensitisation will require improvements in diagnostic testing.

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“…Similar interregional differences in mite populations and allergen levels were observed in Spain (40). The population dynamic of dust mites is infl uenced by temperature, humidity, and housing characteristics (heating, ventilation) (14,41,42). Table 5 shows exposure profi les to mite allergens in fl oor dust (uncarpeted) in different geographic locations worldwide.…”

Section: Mitesmentioning

confidence: 70%

Arthropod Allergens in Urban Homes

Prester¹

2012

Archives of Industrial Hygiene and Toxicology

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House‐dust‐mite allergen concentrations (Der f 1) and mold spores in apartment bedrooms before and after installation of insulated windows and central heating systems

Abstract: The findings of this study suggest that the installation of insulated windows and central heating systems is associated with an increase of Der f 1 concentrations in carpet and mattress dust and of A. fumigatus in carpet dust in apartment bedrooms.

Cited by 50 publications

References 10 publications

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

The link between fungi and severe asthma: a summary of the evidence

Arthropod Allergens in Urban Homes

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