Houdini Tumor: Case Report and Literature Review of Pregnancy-Associated Meningioma

Chakravarthy, Vikram; Kaplan, Brett; Gospodarev, Vadim; Myers, Hannah; Reyes, Kenneth De Los; Achiriloaie, Adina

doi:10.1016/j.wneu.2018.03.187

Cited by 29 publications

(19 citation statements)

References 17 publications

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“…The risk of meningioma in female patients with one or more previous pregnancies does not seem to be increased (25-27, 30, 32, 34-37). The onset of neurological symptoms of a known or a still undiagnosed meningioma during pregnancy (more often at the second or third trimester) or at delivery is a rare event which has been reported in 150 cases, as confirmed by several literature reviews (13,38,39).…”

Section: Pregnancymentioning

confidence: 85%

Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Maiuri¹,

Mariniello²,

Somma³

et al. 2020

Front. Oncol.

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BackgroundSeveral epidemiological and pathological findings suggest that the female sex hormones may influence the development of meningiomas. However, the role of pregnancy, oral contraceptives, and fertilization therapies is still controversial.MethodsFrom the surgical series of 354 patients with meningiomas operated between 2006 and 2019, the group of 72 premenopausal women was separately considered. The tumor location, WHO grade, Ki67-labeling index (LI), progesterone receptor (PR) expression, and histological types were studied in premenopausal women with and without hormone-related conditions were compared.ResultsIn this premenopausal group, 24 patients had hormone-related conditions, including use of oral contraceptives in 16, intrauterine fertilization in one, pregnancy in three, and tumors of the female reproductive system in four. The group of patients with hormone-related conditions, as compared to that with no hormone related conditions, showed slightly lower median age (38 versus 43 years) and no significant difference of meningioma location WHO grade, Ki 67-Li, PR expression and histological type. The clinical onset during pregnancy in three patients and tumor growth during contraceptive progesterone therapy in two others were evidenced.ConclusionThe biological behavior of meningiomas and their pathological findings, including PR expression, are not correlated with the different hormone related conditions in premenopausal female patients. Contraceptives and fertilization therapies, mainly with progesterone, should be avoided in patients with meningiomas.

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Section: Pregnancymentioning

confidence: 85%

Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Maiuri¹,

Mariniello²,

Somma³

et al. 2020

Front. Oncol.

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“…CNS tumours can cause nausea and vomiting too. If severe nausea and vomiting present for the first time after the first trimester, other causes should be considered, including raised intracranial pressure [ 11 ]. In this case, the symptoms of nausea and vomiting were caused by the increased intracranial pressure, and abnormal liver function was due to long-term nausea and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“… Highlights Haemangiopericytoma is a rare and aggressive type of soft tissue sarcoma that arises from pericytes of the capillaries and involves mostly the musculoskeletal system. Its presentation [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] ] in the central nervous system is very rare. Diagnosis was made at 34 weeks of pregnancy after several hospital admissions for nausea and vomiting starting at 20 weeks gestation.…”

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confidence: 99%

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Central nervous system solitary fibrous tumour/hemangiopericytoma presenting as nausea, vomiting and hepatic dysfunction after the first trimester of pregnancy: A case report

Wang

et al. 2021

Case Reports in Women's Health

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“…PR receptor expression is more frequently found in benign (WHO grade I) meningiomas [8]. Meningiomas can enlarge and become symptomatic during pregnancy, only to subsequently decrease in size post-partum [7,9]. These observations raised the question of whether the use of high dose exogenous progesterone or estrogen agonists used during fertility treatments is associated with an increased risk of meningioma.…”

Section: Introductionmentioning

confidence: 99%

Fertility treatment is associated with multiple meningiomas and younger age at diagnosis

et al. 2019

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Purpose: Meningiomas are more common in females and 70-80% express the progesterone receptor, raising the possibility that high-dose exogenous estrogen/progesterone exposure, such as occurs during fertility treatments, may increase the risk of developing a meningioma. The goal of this study was to report the incidence of prior fertility treatment in a consecutive series of female meningioma patients. Methods: A retrospective review (2015-2018) was performed of female patients with meningioma, and those with prior fertility treatment were compared to those without fertility treatment using standard statistical methods. Results: Of 206 female patients with meningioma, 26 (12.6%) had a history of fertility treatments. Patients underwent various forms of assisted reproductive technology including: in vitro fertilization (50.0%), clomiphene with or without intrauterine insemination (34.6%), and unspecified (19.2%). Median follow up was 1.8 years. Tumors were WHO grade I (78.6%) or grade II (21.4%). Patients who underwent fertility treatments presented at significantly younger mean age compared to those who had not (51.8 vs 57.3 yrs, p = 0.0135, 2-tailed T-test), and on multivariate analysis were more likely to have multiple meningiomas (OR: 4.97, 95% CI: 1.4-18.1, p = 0.0154) and convexity/falx meningiomas (OR: 4.45, 95% CI: 1.7-11.5, p = 0.0021). Conclusions: Patients in this cohort with a history of fertility treatment were more likely to present at a younger age and have multiple and convexity/falx meningiomas, emphasizing the importance of taking estrogen/progesterone exposure history when evaluating patients with

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Houdini Tumor: Case Report and Literature Review of Pregnancy-Associated Meningioma

Cited by 29 publications

References 17 publications

Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Central nervous system solitary fibrous tumour/hemangiopericytoma presenting as nausea, vomiting and hepatic dysfunction after the first trimester of pregnancy: A case report

Fertility treatment is associated with multiple meningiomas and younger age at diagnosis

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