Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Maiuri, Francesco; Mariniello, Giuseppe; Somma, Teresa; Guadagno, Elia; Corvino, Sergio; Pagano, Serena; Orlando, Valentina; De, Marialaura Del Basso

doi:10.3389/fonc.2020.556701

Cited by 15 publications

(11 citation statements)

References 49 publications

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“…Furthermore, given that the female-to-male incidence rate ratios were the highest in those aged 35-54 years old, it is important to carefully examine meningioma incidence and survival in middle-aged females. Over the past two decades, researchers have been investigating the sex hormone dependence of meningiomas ( 18 ). The accelerated growth rate during pregnancy and the luteal phase of the menstrual cycle, as well as the greater occurrence in females, point to the possibility that sex hormones may play a role in the development of meningiomas ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the occurrence of meningiomas in women cannot be explained by variations in sex hormone receptors, according to Korhonen et al., who reported no difference in sex hormone receptor expression between sex and age groups ( 25 ). Progesterone and antiprogesterone have been reported to control meningioma growth in vitro ; however, the moderate effects of anti-progesterone on patient outcomes point to a more nuanced interaction between sex hormones and meningioma growth ( 18 ). Therefore, the mechanism of sex discrimination in meningiomas remains controversial ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

et al. 2023

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BackgroundThe incidence of meningioma is disparate to sex: meningiomas are more common in women than in men, especially in middle-aged women. Understanding the epidemiology and survival of middle-aged women with meningiomas would help estimate their public health impacts and optimize risk stratification.MethodsData on middle-aged (35–54 years) female patients with meningiomas between 2004 and 2018 were obtained from the SEER database. Age-adjusted incidence rates per 100 000 population-years were calculated. Kaplan-Meier and multivariate Cox proportional hazard models were utilized in the overall survival (OS) analysis.ResultsData from 18302 female patients with meningioma were analyzed. The distribution of patients increased with age. Most patients were White and non-Hispanic, according to race and ethnicity, respectively. Over the past 15 years, non-malignant meningiomas have shown an increasing trend; however, malignant meningiomas have shown an opposite trend. Older age, Black population, and large non-malignant meningiomas tend to have worse prognoses. Surgical resection improves OS, and the extent of resection is a critical prognostic factor.ConclusionsThis study observed an increase in non-malignant meningiomas and a decrease in the incidence of malignant meningiomas in middle-aged females. The prognosis deteriorated with age, in Black people, and with large tumor size. Additionally, the extent of tumor excision was found to be a significant prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

et al. 2023

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“…This is due to the presence of progesterone and estrogen receptors in meningioma tissue, the possible association of the tumor with the female system, biological changes in meningioma during the menstrual cycle and pregnancy, regression occasionally reported after delivery, in vitro proliferation of meningioma cell lines in culture after exposure to estrogen and progesterone. In addition, the incidence and risk of meningioma in patients with sex hormone-associated conditions and during the use of exogenous sex hormones for contraceptive therapy have been investigated in several studies 9 .…”

Section: Discussionmentioning

confidence: 99%

Clinical Findings And Visual Pathway Disorders Due To Tumor, What MRI can be Found?

Gunawan¹,

Sensusiati²

2022

IJRP

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The 10 th most common cause of mortality for both men and women is brain and other nervous system cancer. These tumors can cause serious ocular signs and symptoms as well as neurologic complications due to increased intracranial pressure, cranial nerve disturbances, or brain compression. CT and MRI are the modalities most commonly used to evaluate visual disturbances around the visual pathway. MRI is the preferred imaging modality for evaluating tumors because it does not use X-rays but uses a magnetic field, producing clearer images

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“…Penelitian yang dilakukan oleh Francesco Maiuri dkk pada tahun 2020 menunjukkan bahwa kasus meningioma lebih sering terjadi pada wanita pasca-menopause dibanding wanita pramenopause dengan perbandingan 3 : 1. 10 Adapun penelitian yang dilakukan oleh Cooper DB pada tahun 2021 di Amerika Serikat menunjukaan bahwa terdapat 25% wanita dengan rentang usia 15-44 tahun yang sedang menjalankan pengobatan hormonal. Korelasi antara usia dengan riwayat pengobatan akan dijelaskan dalam tabel berikutnya.…”

Section: Hasil Dan Pembahasanunclassified

Karakteristik Pasien Meningioma di RSUD Ulin Banjarmasin Tahun 2018-2020

Raharjanti

Suhendar²,

Fakhrurrazy

et al. 2022

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Meningioma are the most common primary tumors in the CNS. Although these tumors are benign, meningioma are a frequent cause of morbidity. This study aims to determine the characteristics of meningioma patients at General Ulin Hospital Banjarmasin in 2018-2020. This study used a retrospective descriptive method from the patient's medical record. The results of this study show that the number of meningioma patients in 2018 was 38 patients (40.4%), in 2019 was 42 patients (44.7%) and in 2020 was 14 patients (14.9%). The most common characteristics were 46-55 range of age (38.3%), female (84%), South Kalimantan (90.4%), Islam (96.8%), private employees (28.7%), BPJS patients (93.6%). All patients had no family history of the disease. Only one patient was recorded as having a history of hormonal treatment (1.1%). Most of the patients had no history of allergies (89.4%). Six patients were classified as class I meningioma (6.4%). The most common tumor location was supratentorial (89.3%). The most common tumor size occurred in the diameter range of 3-6 cm (33%). The most common clinical symptom that appeared was headache (57.4%). GCS scores pre and post operative the most, including mild-normal. The length of treatment for the most patients was more or equal to 10 days (54.3%). The most patient’s outcome was recovered (90.4%). Keywords: Meningioma, characteristics Abstrak: Meningioma adalah tumor primer tersering di SSP. Meskipun tumor ini bersifat jinak, meningioma sering menjadi penyebab morbiditas. Penelitian ini bertujuan untuk mengetahui karakteristik pasien meningioma di RSUD Ulin Banjarmasin tahun 2018-2020. Penelitian ini menggunakan metode deskriptif retrospektif dari rekam medis pasien. Hasil penelitian ini menunjukkan jumlah pasien meningioma terbanyak terjadi tahun 2019 sebanyak 42 pasien (44,7%). Karakteristik terbanyak terjadi pada rentang usia 46-55 tahun (38,3%), jenis kelamin perempuan (84%), alamat asal Kalimantan Selatan (90,4%), agama Islam (96,8%), pekerjaan pegawai swasta (28,7%) dan jaminan kesehatan berupa BPJS (93,6%). Semua pasien tidak memiliki riwayat keluarga. Sebagian besar pasien tidak memiliki riwayat alergi (89,4%). Lokasi tumor terbanyak di supratentorial (89,3%). Ukuran tumor terbanyak adalah diameter 3-6 cm (33%). Gejala klinis terbanyak adalah nyeri kepala (57,4%). Skor GCS datang dan pulang terbanyak termasuk ringan-normal. Lama perawatan pasien terbanyak adalah ≥10 hari (54,3%). Luaran terbanyak adalah sembuh (90,4%). Kesimpulan penelitian ini adalah karakteristik terbanyak pasien meningioma terjadi pada rentang usia 46-55 tahun, jenis kelamin perempuan, alamat asal Kalimantan Selatan, agama Islam, pekerjaan pegawai swasta, pasien BPJS, tidak ada riwayat penyakit keluarga, lokasi tumor supratentorial, diameter 3-6 cm, gejala nyeri kepala, skor GCS ringan-normal, lama perawatan ≥10 hari, dan luaran terbanyak sembuh. Kata-kata kunci: karakteristik, meningioma

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Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

Cited by 15 publications

References 49 publications

Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

Clinical Findings And Visual Pathway Disorders Due To Tumor, What MRI can be Found?

Karakteristik Pasien Meningioma di RSUD Ulin Banjarmasin Tahun 2018-2020

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