“Hotheaded”: The role OF TRPV1 in brain functions

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

“…Finding an appropriate antibody against TRPV1 to use in the western blotting study was a challenge. A number of papers have questioned the presence of TRPV1 in the brain (Fogaça et al, 2012;Madasu et al, 2015;Martins et al, 2014). However, recently, Navarria et al, demonstrated that TRPV1 is present in the hippocampus, and is upregulated in Wistar rats exposed to restraint stress (Navarria et al, 2014).…”

NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice

“…In this regard, it has been accepted that 52 acute phase of psychostimulant withdrawal is associated 53 with abnormal glutamatergic neurotransmission in several 54 brain areas that may be associated with negative affect 55 observed in early recovery state (Kalivas and Volkow,56 2005; D' Souza and Markou, 2010 Marzo et al, 2008;Terzian et al, 2009;Ho et al, 83 2012 (Manna and Umathe, 2012;Abdelhamid et al, 87 2014). Furthermore, it has been reported that TRPV1 88 plays a role in pathophysiology of addiction (Wescott 89 et al, 2013;Martins et al, 2014). Expression of TRPV1 90 undergoes alterations following stimulant administration 91 in the brain, (Tian et al, 2010) and also these channels 92 have been shown to have a regulatory role in morphine-93 induced reward (Nguyen et al, 2014) Open-field test (OFT) 145 The OFT was used to evaluate the locomotion of animals 146 in response to AW and different treatments according to 147 the criteria described by Amiri et al (2015a) (Shoptaw et al, 2009;Chomchai and Chomchai, 2015).…”

“…It has been well-established that AW 453 induces potent depressive behaviors in both animals454 and humans(Barr and Markou, 2005) Martins et al, 2014;. Aguiar et al, 2014).470 These channels are widely distributed in brain structures 471 such as limbic system and cortical areas which are critical 472 regions of the brain involved in cognitive and behavioral 473 processes(Cristino et al, 2006;Edwards, 2014).…”

Receptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors

“…Co-localization of CB 1 and TRPV1 receptors can occur for example in the rat sensory neurons of the DRG [1], in cerebrovascular endothelial cells and in several brain areas including glial cells [146]. It has also been published that cannabidiol, but not other cannabinoids, enhanced microglial phagocytosis through TRPV1 activation [147].…”

“…All three of them are related to pain, although through different signaling pathways and are expressed in similar areas of the central and peripheral nervous system, related to pain modulation. These regions are the primary afferent neurons, DRG, the dorsal horn of the spinal cord and the PAG [146,181]. There are many other physiological and pathological effects in which these receptors are involved, for example psychiatric disorders [25,146,182,183], memory and learning [146,[183][184][185] or thermoregulation [37,146,185].…”