Receptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors

Zádor, Ferenc; Wollemann, M

doi:10.1016/j.phrs.2015.10.015

Cited by 29 publications

(25 citation statements)

References 175 publications

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“…As TRPV1 channel and CB1/CB2 receptors are found to be co-expressed in human osteoclast and mesenchymal stem cells, selective TRPV1 channel agonist resiniferatoxin increased the activity of osteoclast, suggesting that TRPV1 channel and CB1/2 receptors might crosstalk in modulating the homoeostasis of bone mineralization and resorption by different actions of anandamide. [32,33] Recently, it is found that the TRPV1 channel and CB1/2 receptors oppositely modulate the activity of human osteoblast in culture, that is, CB2 receptor promoting osteogenesis whereas TRPV1 channel inhibiting osteogenesis in glucocorticoid-or OVXinduced bone mass loss. [34,35] Consistently, osteoclasts from patients with osteosarcoma shows significant increase of pro-osteoporotic tartrate-resistant acid phosphatase (TRAP) and decrease of CB2 receptor when compared to osteoclasts from healthy donors.…”

Section: Interaction Of Cb Receptors With Trpv1 Channelmentioning

confidence: 99%

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review

Wang

2019

Journal of Pharmacy and Pharmacology

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Objective Osteoporosis is a skeletal disease with decreased bone mass and alteration in microarchitecture of bone tissue, and these changes put patients in risk of bone fracture. As a common symptom of osteoporosis and complication of osteoporotic fracture, chronic pain is a headache for clinicians. Nonsteroidal anti‐inflammatory drugs (NSAIDs), selective COX‐2 inhibitors and opioid drugs can temporarily reduce osteoporotic pain but have relevant side effects, such as addiction, tolerability and safety. The review summarized the recent advancements in the study of CB receptors in osteoporosis and osteoporotic pain and related mechanisms. Key findings Recent studies indicated the two nociceptive receptors, cannabinoid receptor (CB) and transient receptor potential vanilloid type 1 (TRPV1) channel, are co‐expressed in bone cells and play important role in the metabolism of bone cells, suggesting that dualtargeting these 2 receptors/channel may provide a novel approach for osteoporotic pain. In addition, both CB receptor and TRPV1 channel are found to be expressed in the glial cells which play vital role in mediating inflammation, chronic pain and metabolism of bone cells, suggesting a role of glial cells inosteoporotic pain. Summary Multiple‐targeting against glial cells, CB receptors and TRPV1 channel may be one effective therapeutic strategy for osteoporotic pain in the future, following the elucidation of the complicated mechanism.

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Section: Interaction Of Cb Receptors With Trpv1 Channelmentioning

confidence: 99%

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review

Wang

2019

Journal of Pharmacy and Pharmacology

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“…Interestingly, a growing amount of evidence indicates that TRP channels, opioid, and cannabinoid receptors interact to form a functional triangle within a ‘receptome’ modulating pain as reviewed in a recent paper by Zador & Wollemann . The bidirectional interactions between the receptor subtypes can be inhibitory or excitatory through direct or indirect actions.…”

Section: Overview Of Techniques To Assess Visceral Sensitivity To Colmentioning

confidence: 99%

“…The bidirectional interactions between the receptor subtypes can be inhibitory or excitatory through direct or indirect actions. For instance, CB 1 receptor activation inhibits sensitization of TRPV 1 channels in mouse afferent neurons and TRPV1 antagonism in combination with elevation of endocannabinoid levels seems to be an innovative new treatment strategy in the treatment of inflammatory pain, at least in animal models . Increased levels of cannabinoids can enhance opioid‐induced analgesia in cancer pain in preliminary clinical trials …”

Section: Overview Of Techniques To Assess Visceral Sensitivity To Colmentioning

confidence: 99%

“…8,30 Interestingly, a growing amount of evidence indicates that TRP channels, opioid, and cannabinoid receptors interact to form a functional triangle within a 'receptome' modulating pain as reviewed in a recent paper by Zador & Wollemann. 31 The bidirectional interactions between the receptor subtypes can be inhibitory or excitatory through direct or indirect actions. For instance, CB 1 receptor activation inhibits sensitization of TRPV 1 channels in mouse afferent neurons and TRPV1 antagonism in combination with elevation of endocannabinoid levels seems to be an innovative new treatment strategy in the treatment of inflammatory pain, at least in animal models.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, CB 1 receptor activation inhibits sensitization of TRPV 1 channels in mouse afferent neurons and TRPV1 antagonism in combination with elevation of endocannabinoid levels seems to be an innovative new treatment strategy in the treatment of inflammatory pain, at least in animal models. 31 Increased levels of cannabinoids can enhance opioidinduced analgesia in cancer pain in preliminary clinical trials. 31 Whether this so-called 'triumvirate' is also a key player in pain modulation at the level of the gut remains to be demonstrated, but if so, this could open the door to new and exciting treatment strategies for visceral pain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel nervous system mechanisms in visceral pain

Winter

Deiteren

Man

2016

Neurogastroenterology Motil

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Visceral hypersensitivity is an important factor underlying abdominal pain in functional gastrointestinal disorders such as irritable bowel syndrome (IBS) and can result from aberrant signaling from the gut to the brain or vice versa. Over the last two decades, research has identified several selective, intertwining pathways that underlie IBS-related visceral nociception, including specific receptors on afferent and efferent nerve fibers such as transient receptor potential channels (TRP) channels, opioid, and cannabinoid receptors. In this issue of Neurogastroenterology and Motility Gil et al. demonstrate that in an animal model with reduced descending inhibitory control, the sympathetic nervous system outflow is enhanced, contributing to visceral and somatic hypersensitivity. They also provide evidence that interfering with the activation of adrenergic receptors on sensory nerves can be an interesting new strategy to treat visceral pain in IBS. This mini-review places these findings in a broader perspective by providing an overview of promising novel mechanisms to alter the nervous control of visceral pain interfering with afferent or efferent neuronal signaling.

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Cannabinoids and Pain: Mechanisms of Action

Narouze

2021

Cannabinoids and Pain

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Receptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors

Cited by 29 publications

References 175 publications

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review

Novel nervous system mechanisms in visceral pain

Cannabinoids and Pain: Mechanisms of Action

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