Hot Water Epilepsy

Szymonowicz, W.; Meloff, Keith L.

doi:10.1017/s0317167100024616

Cited by 50 publications

(38 citation statements)

References 15 publications

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“…Previous studies also pointed to a temporal lobe origin in 67%-100% of patients with HWE. [40][41][42] Interictal EEG results are usually normal in most of the cases, but a few case studies showed localized temporal lobe discharges. 41,43 Isolated case reports of associated hippocampal sclerosis have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI

Bharath

Sinha²,

Panda

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The frequency of seizures is an important factor that can alter functional brain connectivity. Analysis of this factor in patients with epilepsy is complex because of disease-and medication-induced confounders. Because patients with hot-water epilepsy generally are not on long-term drug therapy, we used seed-based connectivity analysis in these patients to assess connectivity changes associated with seizure frequency without confounding from antiepileptic drugs.

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Section: Discussionmentioning

confidence: 99%

Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI

Bharath

Sinha²,

Panda

et al. 2015

AJNR Am J Neuroradiol

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“…Hyperperfusion areas have been reported via single photonemission computed tomography in certain cases of HWE (10). Patients with HWE who have focal epileptic activity originating from the temporal or parietal lobes on EEG, temporal hippocampal sclerosis, dysplasia, cystic changes, and other abnormal findings such as cavum septopellucidum and pachygyria on MRI have also been reported (4,11,12,13). The MRI and EEG results in our patients were normal.…”

Section: Discussionmentioning

confidence: 44%

“…HWE constitutes 3.6-3.9% of all epilepsy cases in India, and most reported cases are from India (3). HWE is most commonly seen during childhood and in males (4). The seizure type can be generalized as tonic clonic as well as complex partial (5).…”

Section: Introductionmentioning

confidence: 99%

Hot Water Epilepsy: Presentation of Three Cases

Ehi¹,

Üstebay²,

Üstebay³

et al. 2016

tnd

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Hot water epilepsy (HWE) is a reflex epilepsy that develops after pouring hot water on the head; seizures are induced through tactile and temperature-related stimuli. The number of cases reported worldwide is low, with most cases in Turkey and India. The exact pathophysiology of HWE is unknown but patients are thought to have abnormal thermoregulation systems with seizures that emerge due to the stimulation of a particular region in the brain cortex via contact of hot water on the skin of the head. We investigated the pathogenesis of this disorder through a literature review and by presenting the clinical and laboratory findings of three patients with HWE. Fortunately, HWE can largely be prevented; however, if non-reflexive seizures co-occur with HWE, proper medical treatment can be added to ensure seizure-free follow-up.Keywords: Hot water, epilepsy, reflex epilepsy Sıcak suyun baştan aşağı dökülmesi ile oluşan, taktil ve sıcaklığa bağlı stimuluslarla uyarılan nöbetlerin ortaya çıktığı refleks epilepsi tipi sıcak su epilepsisi (SSE) olarak tanımlanmıştır. Literatürde en çok Türkiye ve Hindistan'dan olgu bildirilmesine rağmen tüm dünyada bildirilmiş olgu sayısı azdır. SSE'nin patofizyolojisi tam olarak bilinmemektedir, ancak hastaların anormal bir termoregülasyon sistemlerinin olduğu, kafa derisinin sıcak suyla teması ile beyin korteksindeki belirli bir bölgenin uyarılması nedeniyle nöbetlerin ortaya çıktığı düşünülmektedir. Çalışmamızda, SSE olan üç hastanın klinik ve laboratuvar bulguları sunularak hastalığın patogenezi literatür eşliğinde incelenmiştir. SSE, gerekli önlemler alındığında çoğunlukla önlenebilen bir refleks epilepsi tipidir. Ancak hastalarda SSE ile birlikte non-refleksif nöbetler de eşlik ediyorsa, uygun medikal tedavi alınan önlemlere eklenerek nöbetsiz başarılı takip sürelerine ulaşılabilir.

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“…There are case reports of HWE from New Zealand (Allen 1945), Australia (Keipert 1969), the United States (Stensman and Ursing 1971), Canada (Szymonowicz and MeloV 1978), the United Kingdom (Moran 1976), Japan (Morimoto et al 1985;Kurata 1979) and Turkey (Bebek et al 2001). However, HWE is most prevalent in India (Mani et al 1974;Satishchandra et al 1988Satishchandra et al , 2003.…”

Section: Introductionmentioning

confidence: 99%

A locus for autosomal dominant reflex epilepsy precipitated by hot water maps at chromosome 10q21.3-q22.3

et al. 2009

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Hot water epilepsy (HWE) is a form of reflex or sensory epilepsy wherein seizures are precipitated by an unusual stimulus, the contact of hot water over the head and body. Genome-wide linkage analysis of a large family with ten affected members, provided evidence of linkage (Z (max) = 3.17 at theta = 0 for D10S412) to chromosome 10q21. Analysis of five additional HWE families, for markers on chromosome 10, further strengthened the evidence of linkage to the same chromosomal region with three out of five families showing concordance for the disease haplotype and providing a two-point LOD score of 4.86 at theta = 0 and 60% penetrance for D10S412. The centromere-proximal and -distal boundaries of the critical genetic interval of about 15 Mb at 10q21.3-q22.3 were defined by D10S581 and D10S201, respectively. Sequence analysis of a group of functional candidate genes, the ion channels KCNMA1, VDAC2 and solute carriers SLC25A16, SLC29A3 revealed no potentially pathogenic mutation. We propose to carry out further analysis of positional candidate genes from this region to identify the gene responsible for this unusual neurobehavioral phenotype.

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Hot Water Epilepsy

Cited by 50 publications

References 15 publications

Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI

Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI

Hot Water Epilepsy: Presentation of Three Cases

A locus for autosomal dominant reflex epilepsy precipitated by hot water maps at chromosome 10q21.3-q22.3

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