Hot spots of antibiotic tolerant and resistant bacterial subpopulations in natural freshwater biofilm communities due to inevitable urban drainage system overflows

Kaeseberg, Thomas; Schubert, Sara; Oertel, Reinhard; Zhang, Jin; Berendonk, Thomas U.; Krebs, Peter

doi:10.1016/j.envpol.2018.06.081

Cited by 23 publications

(6 citation statements)

References 42 publications

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“…The increasing presence of antibiotic compounds in the environment is therefore of great concern. Environmental biofilms downstream of a sewer overflow site exhibit increased antibiotic resistance ( Kaeseberg et al, 2018 ). Moreover, antibiotic resistance genes and resistant organisms are often found in natural waterways and can also persist for prolonged periods of time within sediments ( Calero-Cáceres et al, 2017 ; Zhu et al, 2017 ; Gillings, 2018 ; Guo et al, 2018 ; Lépesová et al, 2018 ).…”

Section: Biofilms In Naturementioning

confidence: 99%

Secondary Effects of Antibiotics on Microbial Biofilms

et al. 2020

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Biofilms are assemblages of microorganisms attached to each other, or to a surface, and encased in a protective, self-produced matrix. Such associations are now recognized as the predominant microbial growth mode. The physiology of cells in biofilms differs from that of the planktonic cells on which most research has been conducted. Consequently, there are significant gaps in our knowledge of the biofilm lifestyle. Filling this gap is particularly important, given that biofilm cells may respond differently to antibiotics than do planktonic cells of the same species. Understanding the effects of antibiotics on biofilms is of paramount importance for clinical practice due to the increased levels of antibiotic resistance and resistance dissemination in biofilms. From a wider environmental perspective antibiotic exposure can alter the ecology of biofilms in nature, and hence disrupt ecosystems. Biofilm cells display increased resilience toward antibiotics. This resilience is often explained by mechanisms and traits such as decreased antibiotic penetration, metabolically inactive persister cells, and intrinsic resistance by members of the biofilm community. Together, these factors suggest that cells in biofilms are often exposed to subinhibitory concentrations of antimicrobial agents. Here we discuss how cells in biofilms are affected by the presence of antibiotics at subinhibitory concentrations, and the possible ramifications of such secondary effects for healthcare and the environment.

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Section: Biofilms In Naturementioning

confidence: 99%

Secondary Effects of Antibiotics on Microbial Biofilms

et al. 2020

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“…158 The presence of the antibiotics such as sulfamethoxazole and ciprooxacin in surface water and soil can lead to the development, maintenance and spread AMR bacteria, fungi and biolm in natural environments. 6,[159][160][161][162] Furthermore, AMR bacteria present in sh from aquaculture has been shown to pass this resistance to humans. 163 However, this transfer is not currently fully known, and further investigation is needed.…”

Section: Impact Of Pharmaceuticals On Human Healthmentioning

confidence: 99%

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

et al. 2021

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“…Microbiological water quality is of interest when a water source is used for drinking water abstractions [46] or when water bodies are used for certain recreational purposes such as water sports [47]. Moreover, rivers are relevant as pathways for the transport of pathogenic microorganisms [38,48], including antibiotic-resistant bacteria that originate from wastewater inputs containing antibiotics and their metabolites [49]. Hygienically relevant microorganisms are defined by at least one of the following criteria: (1) They are excreted by humans or animals in high doses or have low infective doses; (2) they can survive in the environment for an extended period of time; (3) they may be difficult to inactivate during water treatment [50].…”

Section: Data Collectionmentioning

confidence: 99%

Hygienic Condition of Different Water Sources in the Kharaa River Basin, Mongolia in the Light of a Rapid Warming Trend

Ochirbold¹,

Tserendorj²,

Westphal

et al. 2020

Atmosphere

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Mongolia is a water-scarce land-locked country, and available water resources are utilized for multiple purposes including irrigation, food preparation, drinking water for livestock and people. Limited data availability on water hygiene means that the related risks to public health are only partially understood. This is particularly problematic due to the widespread use of unimproved water sources such as surface water and water from simple shallow wells. Based on two field surveys in the Kharaa River Basin in spring 2017 and 2018, we assessed the presence and quantity of total coliforms (TC), fecal coliforms (FC), and E. coli bacteria in surface waters and wells and investigated potential linkages between temperature and hygiene. In the Kharaa River and its tributaries, TC concentrations averaged at a most probable number of (MPN) of 754 ± 761 per 100 mL and FC concentrations at an MPN of 31 ± 33. Only small and non-significant correlations between coliform concentrations and temperature were identified. Coliforms concentrations in wells were lower (average MPN for TC: 550 ± 1286, and for FC 58 ± 253). There was considerable variation between wells, with moderate but significant correlations between temperature and bacterial counts. Low water temperatures in April and May (just above freezing to less than 6.5 °C in wells and 7.5 °C to 14.5 °C in the river system) and the positive correlations between temperature and coliform concentrations particularly for well samples indicate that further warming is likely to increase the risks of microbiological water pollution. In the future, this should be complemented by modeling at a watershed scale. This should include the consideration of a trend towards stronger rainfall events, changes in livestock density, and urban sewage treatment and discharge, which are other likely drivers of changes in water hygiene.

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Hot spots of antibiotic tolerant and resistant bacterial subpopulations in natural freshwater biofilm communities due to inevitable urban drainage system overflows

Cited by 23 publications

References 42 publications

Secondary Effects of Antibiotics on Microbial Biofilms

Secondary Effects of Antibiotics on Microbial Biofilms

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

Hygienic Condition of Different Water Sources in the Kharaa River Basin, Mongolia in the Light of a Rapid Warming Trend

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