Hot melt granulation of coarse pharmaceutical powders in a spouted bed

Influence of contactor geometry and draft tube configuration on the cycle time distribution in sawdust conical spouted beds

“…Thus, recent applications are those involving physical processes, as are: drying of seeds, pharmaceutical Page 3 of 42 A c c e p t e d M a n u s c r i p t 3 powders and biomaterials (Devahastin et al, 1998, Konopka et al, 2008, Markowski et al, 2010, drying of sawdust (Berghel et al, 2008), granulation (Borini et al, 2009), coating (Rocha et al, 2009), heat carrier (Prachayawarakorn et al, 2006) and solid mixing (Hao et al, 2008). The applications in chemical processes include gasification (Spiegl et al, 2010), combustion (Lim et al, 1988, Konduri et al, 1999, Rasul, 2001, San José et al, 2014 and pyrolysis (Aguado et al, 2000a, Aguado et al, 2000b, Elordi et al, 2009, Artetxe et al, 2010 Different modifications of the original spouted bed have been proposed in the literature with the aim of improving performance.…”

Development of a Phytopharmaceutical Intermediate Product via Spray Drying

“…[47] The SDE properties chosen as quality indicators in this investigation were the particle size, density, moisture content, flowability, and compactability, all of which are closely related to a powder's adequateness for further tableting and capsule filling. [34,[47][48][49][50] Moreover, additional information on process adequacy is supplied by powder recovery or process yields. [18] As can be seen in Table 3, the values of process yields (Py) ranged from 57.55 to 89.14%, with the highest yield obtained with mannitol at the lowest concentration.…”

Three-dimensional multi-phase simulation of the mixing and segregation of binary particle mixtures in a two-jet spout fluidized bed

“…Owing to its advantages of heat and mass transfer, gas-solid mixing, and fuel adaptability, the spout fluidized bed has been widely applied in chemical, energy, and environmental industries (Borini, Andrade, & Freitas, 2009;Calo, Madhavan, Kirchner, & Bain, 2012;El-Naas, Al-Zuhair, & Makhlouf, 2010;Olazar, Arandes, Zabala, Aguayo, & Bilbao, 1997). Materials in spout fluidized bed reactors often consist of multi-component particle mixtures with different densities and/or sizes.…”