Development of a Phytopharmaceutical Intermediate Product via Spray Drying

Abstract

The influence of concentration and incorporation time of different drying excipients on the processing yields and physical properties of Eugenia dysenterica DC spray-dried extracts were investigated following a factorial design. Under the established conditions, the process yield ranged from 57.55 to 89.14%, and in most experiments, the recovered products presented suitable flowability and compressibility, as demonstrated by the Hausner factor, Carr index, and angle of repose. Additionally, in a general way, the parameters related to the dried products' flowability varied over a range acceptable for pharmaceutical purposes. An analysis of variance (ANOVA) proved that both factors and some of their interactions significantly affected most of the investigated responses at different levels. Mannitol proved to be an interesting alternative as an excipient for the drying of herbal extracts, even at low concentrations such as 12.5%. Furthermore, these results imply that the best condition to obtain dry extracts of E. dysenterica with high performance and adequate pharmacotechnical properties involves the lowest concentration and the highest incorporation time of mannitol.

Eugenia dysentericaDC. (Myrtaceae) exerts chemopreventive effects against hexavalent chromium-induced damagein vitroandin vivo

“…The lyophilized hydroalcoholic extract (yield: 19.5%, w/w) was obtained through the percolation of leaf powder (1 kg) in ethanol:water solution (70:30, v/v), standardized by determination of its major phytochemical markers (3.45% and 53.7% of tannins and flavonoids, respectively) and used for developing of a product via spray drying, as previously described by our research colleagues (Couto et al 2009(Couto et al , 2011(Couto et al , 2012(Couto et al , 2013.…”

Optimization of the Spray‐Drying Process for Developing Jabuticaba Waste Powder Employing Response Surface Methodology

“…The greatest challenge in producing phytopharmaceutical and nutraceutical materials is the difficulty of producing standardized extracts with desired contents of chemical markers (Couto et al 2011). The values of EAc, TPc, TFc, Mc and Aw quantified in the dried extracts from jabuticaba wastes (seeds and peels) ranged from 0.056 to 0.09%, 7.17 to 20.15%, 3.93 to 6.36%, 3.98 to 8.76%, and 0.17 to 0.32, respectively.…”

Sistemas microestruturados contendo extratos de Chamomilla recutita L. para aplicações dermocosméticas

“…A ampla utilização das micropartículas em formulações farmacêuticas é devido às vantagens que a microencapsulação proporciona, tais como aumento da estabilidade do composto encapsulado, sustentação e controle da liberação dos ativos, desenvolvimento de novos sistemas de liberação, maior facilidade na incorporação de ativos e redução na perda de substâncias voláteis (CAO-HOANG;FOUGÈRE;WACHÉ, 2011;GELFUSO et al, 2011;GHARSALLAOUI et al, 2007;MARCATO, 2009;. Outra vantagem é que as micropartículas produzidas podem ser industrialmente utilizadas como um produto final com diferentes aplicações terapêuticas, ou como um produto intermediário nas preparações farmacêuticas (COUTO et al, 2011).…”

“…No entanto, o spray freeze drying não pode ser operado de forma contínua e é um processo caro, pois requer um alto tempo para secagem das micropartículas e geralmente utiliza vácuo para secagem (AL-HAKIM; STAPLEY, 2004; BOWEY; NEUFELD, 2010). Mesmo assim, o processo de spray freeze drying é promissor para a produção de micropartículas contendo derivados de plantas, uma vez que pode conciliar as vantagens das técnicas de spray drying e liofilização, duas importantes técnicas usadas para a produtos vegetais (CHAN;CHEW, 2003;COUTO et al, 2011;GAO et al, 2011;NIWA et al, 2009).…”