Hot embossing and mechanical punching of biodegradable microcontainers for oral drug delivery

Petersen, Ritika Singh; Mahshid, Rasoul; Andersen, Nis Korsgaard; Keller, Stephan Sylvest; Hansen, Hans Nørgaard; Boisen, Anja

doi:10.1016/j.mee.2014.11.009

Cited by 18 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To address this issue, Petersen et al have recently presented two approaches for fabrication of individual biodegradable polymer microcontainers based on mechanical punching ( Figure 2D) 28 and hot punching ( Figure 2E) 29 . In the latter, a soft PDMS layer is introduced between the biodegradable polymers and the Si substrates.…”

Section: Microcontainersmentioning

confidence: 99%

Microfabricated devices for oral drug delivery

Nielsen

Keller

2018

Lab Chip

Self Cite

View full text Add to dashboard Cite

Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication. The physical barriers in the body, low pH of the stomach and degradation by enzymes in the gastrointestinal tract are a few of the obstacles to succeeding with oral drug delivery. Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells. Here, we review the newest development in top-down microfabricated devices for oral drug delivery with coverage of the aspects of design, choice of material and fabrication techniques. Furthermore, the drug loading techniques and methods for testing are discussed. In addition, we discuss the future perspectives for microfabricated devices.

show abstract

Section: Microcontainersmentioning

confidence: 99%

Microfabricated devices for oral drug delivery

Nielsen

Keller

2018

Lab Chip

Self Cite

View full text Add to dashboard Cite

show abstract

“…22 During the embossing process, the PLLA polymer is above its glass transition temperature of 55 º-60 ºC in a viscoelastic state. This viscoelastic layer lies on the elastic PDMS film.…”

Section: Hot Punching Of High-aspect-ratio 3d Polymeric Microstructurmentioning

confidence: 99%

Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery

2015

Self Cite

View full text Add to dashboard Cite

COMMUNICATION This journal is © The Royal Society of Chemistry 2015Lab Chip, 2015, 00, 1-3 | 1 Oral drug delivery is the most preferable route of drug delivery. This is due to the ease of administration, flexibility in dosage and most importantly, patient compliance. 1 However, there are challenges with this route of delivery. These are non-specificity of the drug, degradation in the acidic environment of the stomach and low drug stability resulting in an overall low bioavailability of active ingredients.2,3 With the recent developments in Microelectromechanical systems (MEMS) technology, there has been high impetus in developing new microfabricated oral drug delivery systems (DDS) like micropatches, microreservoirs and micropore based devices. 4,5

show abstract

“…Coating of the API-loaded cavity protects the content from the harsh environment of the stomach and provides unidirectional release at a relevant site in the GI tract [16]. Due to versatile fabrication processes, microcontainers have been fabricated in different materials, shapes and size ranges [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Christfort

Guillot²,

Melero³

et al. 2020

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on in vitro release, in situ mucoadhesion and in situ absorption of amoxicillin. Additionally, the mucoadhesion of empty cylindrical microcontainers with and without pillars on the top surface was investigated. From the microscopy analysis of the colon sections after the in situ study, it was evident that a significantly higher percentage of cubic microcontainers than cylindrical microcontainers adhered to the intestinal mucus. Furthermore, the absorption rate constants and blood samples indicated that amoxicillin in cubic microcontainers was absorbed more readily than when cylindrical or triangular microcontainers were dosed. This could be due to a higher degree of mucoadhesion for these particular microcontainers.

show abstract

Hot embossing and mechanical punching of biodegradable microcontainers for oral drug delivery

Cited by 18 publications

References 20 publications

Microfabricated devices for oral drug delivery

Microfabricated devices for oral drug delivery

Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Contact Info

Product

Resources

About