Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery

Petersen, Ritika Singh; Keller, Stephan Sylvest; Boisen, Anja

doi:10.1039/c5lc00372e

Cited by 19 publications

(18 citation statements)

References 27 publications

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“…Hot punching PLLA, PCL 29 Sealed microcontainers Spray coating Eudragit L100 11,12,18 Sealed microcontainers Thermal bonding PLGA, PC, PMMA 21,30 Microfabrication technologies and materials…”

Section: Microcontainersmentioning

confidence: 99%

“…However, the main drawback is that it is that is an epoxy based resin and potential accumulation in the GI tract could lead to unwanted side effects. Therefore, several methods for fabrication of drug delivery devices using biodegradable polymers have been proposed 26,27,29 . Tao et al have used soft lithography with SU-8 microstructures to prepare PDMS masters and subsequently performed microtransfer molding to define microwells in poly(lactic-glycolic acid) (PLGA) and gelatine ( Figure 2C) 26 .…”

Section: Microcontainersmentioning

confidence: 99%

“…To address this issue, Petersen et al have recently presented two approaches for fabrication of individual biodegradable polymer microcontainers based on mechanical punching ( Figure 2D) 28 and hot punching ( Figure 2E) 29 . In the latter, a soft PDMS layer is introduced between the biodegradable polymers and the Si substrates.…”

Section: Microcontainersmentioning

confidence: 99%

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Microfabricated devices for oral drug delivery

Nielsen

Keller

2018

Lab Chip

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Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication. The physical barriers in the body, low pH of the stomach and degradation by enzymes in the gastrointestinal tract are a few of the obstacles to succeeding with oral drug delivery. Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells. Here, we review the newest development in top-down microfabricated devices for oral drug delivery with coverage of the aspects of design, choice of material and fabrication techniques. Furthermore, the drug loading techniques and methods for testing are discussed. In addition, we discuss the future perspectives for microfabricated devices.

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Section: Microcontainersmentioning

confidence: 99%

Section: Microcontainersmentioning

confidence: 99%

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Microfabricated devices for oral drug delivery

Nielsen

Keller

2018

Lab Chip

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“…Boisen and co-workers recently employed an inkjet printer to load a drug solution into microdevice reservoirs [121, 122], which is a quasi-no-waste performance technique as shown in Figure 4 B. They also loaded microdevice reservoirs with hydrophobic drugs in the absence of toxic organics by incorporating supercritical fluid impregnation with inkjet printing [123].…”

Section: Loading Of Novel Micro- and Nanoscale Oral Drug Delivery mentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

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The oral route of drug administration is most preferred due to its ease of use, low cost, and high patient compliance. However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration. The flexibility of micro- and nanofabrication techniques has been used to create drug delivery platforms designed to address these barriers to oral drug uptake. Specifically, micro/nanofabricated devices have been designed with planar, asymmetric geometries to promote device adhesion and unidirectional drug release toward epithelial tissue, thereby prolonging drug exposure and increasing drug permeation. Furthermore, surface functionalization, nanotopography, responsive drug release, motion-based responses, and permeation enhancers have been incorporated into such platforms to further enhance drug uptake. This review will outline the application of micro/nanotechnology to specifically address the physiological barriers to oral drug delivery and highlight technologies that may be incorporated into these oral drug delivery systems to further enhance drug uptake.

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“…Petersen et al reported hot punching as a modified hot embossing method of fabricating high aspect ratio 3D polymeric microstructures forming a reservoir with a volume in the nanoliter range for drug delivery [58]. An elastic PDMS layer was deposited between the poly-L-lactic acid (PLLA) layer and the hard Si substrate.…”

Section: Microreservoir-based Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery Using Microdevices

Sanjay

Dou

et al. 2016

CPB

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Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal concentration of drugs at the desired site. Controlled drug delivery aims to localize the pharmacological activity of the drug to the desired site at desired release rates. The advances made by micro/nanofluidic technologies have provided new opportunities for better-controlled drug delivery. Various components of a drug delivery system can be integrated within a single tiny micro/nanofluidic chip. This article reviews recent advances of controlled drug delivery made by microfluidic/nanofluidic technologies. We first discuss microreservoir-based drug delivery systems. Then we highlight different kinds of microneedles used for controlled drug delivery, followed with a brief discussion about the current limitations and the future prospects of controlled drug delivery systems.

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Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery

Cited by 19 publications

References 27 publications

Microfabricated devices for oral drug delivery

Microfabricated devices for oral drug delivery

Micro/nanofabricated platforms for oral drug delivery

Controlled Drug Delivery Using Microdevices

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