Hot cross bun and bright middle cerebellar peduncle signs in cerebellar type multiple system atrophy

Cicilet, Soumya; Furruqh, Farha; Biswas, Asthik; Philip, Babu

doi:10.1136/bcr-2017-220576

Cited by 5 publications

(3 citation statements)

References 7 publications

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“… 3 Additionally, the MCP sign can also appear in other conditions that cause degenerative cerebellar ataxia, including multiple-system atrophy—cerebellar type (MSA-C) and fragile X-associated tremor/ataxia syndrome (FXTAS). 4 However, the present study did not produce genetic findings of FXTAS. Previous imaging data inferred that the MCP sign could be accompanied by a hot-cross-bun sign in MSA-C and corpus callosum thinning in FXTAS.…”

contrasting

confidence: 73%

Antisaccades in Spinocerebellar Ataxia Type 17 With Middle Cerebellar Peduncle Hyperintensities Without Hot-Cross-Bun Sign

Lee,

Kwon,

et al. 2024

J Clin Neurol

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contrasting

confidence: 73%

Antisaccades in Spinocerebellar Ataxia Type 17 With Middle Cerebellar Peduncle Hyperintensities Without Hot-Cross-Bun Sign

Lee,

Kwon,

et al. 2024

J Clin Neurol

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“…The differential diagnosis included glioma, lymphoma, JC virus granule cell neuronopathy, and demyelinating disease. However, the combination of the hot cross bun sign in the pons ( Picture A , arrowhead) and a bright MCP sign led to a diagnosis of cerebellar-type multiple system atrophy ( 1 ). A bright MCP sign indicates degeneration and volume loss in the peduncle ( 1 ).…”

mentioning

confidence: 99%

“…However, the combination of the hot cross bun sign in the pons ( Picture A , arrowhead) and a bright MCP sign led to a diagnosis of cerebellar-type multiple system atrophy ( 1 ). A bright MCP sign indicates degeneration and volume loss in the peduncle ( 1 ). Some patients with multiple system atrophy show marked clinical and pathological laterality ( 2 ).…”

mentioning

confidence: 99%

A Unilateral Bright Middle Cerebellar Peduncle Sign

Shiraishi

2021

Intern. Med.

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The “Hot Cross Bun Sign” in Spinocerebellar Ataxia Types 2 and 7–Case Reports and Review of Literature

Naidoo

Wells

Rugbeer

et al. 2022

Movement Disord Clin Pract

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Background The “hot cross bun” sign is a cruciform hyperintensity is seen on T2 weighted imaging within the pons. The sign is considered to be pathognomic for Multiple system atrophy type C. The clinical and radiological features of Multiple system atrophy type C overlap with the autosomal dominant inherited ataxias. We present a case series of 3 African patients with genetically proven Spinocerebellar Ataxia presenting with the Hot cross bun sign and a scoping review of similar studies. Cases We described the phenotypic and radiological presentation of genetically confirmed SCA‐2 in two, and SCA‐7 in one patient, with the “hot cross bun” sign. Literature Review We performed a scoping review on the Hot Cross Bun Sign. A total of 66 articles were retrieved. We describe the diverse aetiologies of the sign and associated phenotypic and radiological features. We review the Spinocerebellar Ataxias described with a Hot cross bun sign and make comparisons to Multiple System Atrophy Type C [Ref. 1,2]. Conclusions To our knowledge this is the first description of an African cohort presenting with the Hot Cross Bun Sign. We expand the differential diagnosis of the Hot Cross Bun Sign.

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Hot cross bun and bright middle cerebellar peduncle signs in cerebellar type multiple system atrophy

Cited by 5 publications

References 7 publications

Antisaccades in Spinocerebellar Ataxia Type 17 With Middle Cerebellar Peduncle Hyperintensities Without Hot-Cross-Bun Sign

Antisaccades in Spinocerebellar Ataxia Type 17 With Middle Cerebellar Peduncle Hyperintensities Without Hot-Cross-Bun Sign

A Unilateral Bright Middle Cerebellar Peduncle Sign

The “Hot Cross Bun Sign” in Spinocerebellar Ataxia Types 2 and 7–Case Reports and Review of Literature

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