Host Responses to Biomaterials and Anti‐Inflammatory Design—a Brief Review

Zhou, Guoying; Groth, Thomas

doi:10.1002/mabi.201800112

Cited by 98 publications

(104 citation statements)

References 189 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…To improve the biocompatibility of biomaterial and to avoid adverse biomaterial‐induced tissue injury, approaches such as physical and chemical modification of the biomaterials and delivery of anti‐inflammatory agents are adopted . Incorporating antioxidants, such as ascorbic acid and vitamins, into biomaterials may protect cells and tissues against ROS injury.…”

Section: Discussionmentioning

confidence: 99%

Effect of metformin on human periodontal ligament stem cells cultured with polydopamine‐templated hydroxyapatite

Zhan

Gao

Zhou

et al. 2019

European J Oral Sciences

View full text Add to dashboard Cite

Polydopamine‐templated hydroxyapatite (tHA) is a type of nano‐biomaterial that can promote osteogenesis in bone tissue engineering. However, high concentrations of tHA stimulate production of reactive oxygen species (ROS), resulting in cell injury and apoptosis. Metformin has been demonstrated to activate the adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway, which induces autophagy and decreases ROS production to prevent apoptosis. The present study was performed to investigate the potential application of tHA in combination with metformin in periodontal bone tissue engineering. Human periodontal ligament stem cells (hPDLSCs) were exposed to tHA in the presence or absence of metformin, and cytocompatibility and osteogenesis were detected by related assays. Additionally, the autophagy signaling pathway was analyzed by western blotting. Polydopamine‐templated hydroxyapatite, in combination with metformin, substantially reduced ROS production and apoptosis, and enhanced proliferation and osteogenic differentiation of hPDLSCs. Enhanced levels of microtubule‐associated protein 1 light chain 3 II and Beclin‐1 were observed after exposure to tHA plus metformin. Expression of phosphorylated AMPK was increased and that of phosphorylated mammalian target of rapamycin (mTOR) was decreased after exposure to tHA plus metformin. Taken together, our results demonstrate that tHA, combined with metformin, increases the viability of hPDLSCs via the AMPK/mTOR signaling pathway by regulating autophagy and further improving the osteogenic effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of metformin on human periodontal ligament stem cells cultured with polydopamine‐templated hydroxyapatite

Zhan

Gao

Zhou

et al. 2019

European J Oral Sciences

View full text Add to dashboard Cite

show abstract

“…As various excellent reviews have elaborated on the mechanism and biological process of the FBR, [ 24,27,72,108–117 ] we briefly summarized these in Figure 1. When biomaterials are implanted into the body, the injury causes blood and body fluids to inevitably contact the surface of implants, and nonspecific adsorption of plasma proteins occurs within seconds, [ 118 ] which is an early‐stage event associated with subsequent inflammation and wound healing process.…”

Section: The Mechanism Of Foreign‐body Responsementioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

161

139

View full text Add to dashboard Cite

Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

show abstract

“…To optimize the response of bone biomaterials and avoid excessive inflammation or implant rejection, different immunomodulation approaches have been adopted to interfere with the immune system [24][25][26][27][28][29][30].…”

Section: Of 19mentioning

confidence: 99%

Macrophage in vitro Response on Hybrid Coatings Obtained by Matrix Assisted Pulsed Laser Evaporation

et al. 2019

View full text Add to dashboard Cite

The improvement in the research area of the implant by surface functionalization when correlated with the biological response is of major interest in the biomedical field. Based on the fact that the inflammatory response is directly involved in the ultimate response of the implant within the body, it is essential to study the macrophage-material interactions. Within this context, we have investigated the composite material-macrophage cell interactions and the inflammatory response to these composites with amorphous hydroxyapatite (HA), Lactoferrin (Lf), and polyethylene glycol-polycaprolactone (PEG-PCL) copolymer. All materials are obtained by Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique and characterized by Atomic Force Microscopy and Scanning Electron Microscopy. Macrophage-differentiated THP-1 cells proliferation and metabolic activity were assessed by qualitative and quantitative methods. The secretion of tumor necrosis factor alpha (TNF-α) and interleukin 10 (IL-10) cytokine, in the presence and absence of the inflammatory stimuli (bacterial endotoxin; lipopolysaccharide (LPS)), was measured using an ELISA assay. Our results revealed that the cellular response depended on the physical-chemical characteristics of the coatings. Copolymer-HA-Lf coatings led to low level of pro-inflammatory TNF-α, the increased level of anti-inflammatory IL-10, and the polarization of THP-1 cells towards an M2 pro-reparative phenotype in the presence of LPS. These findings could have important potential for the development of composite coatings in implant applications.

show abstract

Host Responses to Biomaterials and Anti‐Inflammatory Design—a Brief Review

Cited by 98 publications

References 189 publications

Effect of metformin on human periodontal ligament stem cells cultured with polydopamine‐templated hydroxyapatite

Effect of metformin on human periodontal ligament stem cells cultured with polydopamine‐templated hydroxyapatite

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Macrophage in vitro Response on Hybrid Coatings Obtained by Matrix Assisted Pulsed Laser Evaporation

Contact Info

Product

Resources

About