Host Response to Biomaterials for Pelvic Floor Reconstruction

Barone, William R.; Abramowitch, Steven D.; Moalli, Pamela

doi:10.1016/b978-0-12-800196-7.00013-x

Cited by 7 publications

(23 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past, pelvic reconstructive surgeons had to balance the higher risk of anatomical failure with native tissue repair with the risk of post-operative complications from mesh augmented repair [ 26 ]. Many surgeons chose to optimize the durability of the repair, and thus the increased use of synthetic non-degradable PP meshes for POP surgery followed [ 27 , 28 , 29 , 30 ] ( Figure 2 ).…”

Section: Pelvic Organ Prolapsementioning

confidence: 99%

Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse

Hennes

Rosamilia

Werkmeister

et al. 2021

JPM

View full text Add to dashboard Cite

Cellular therapy is an emerging field in clinical and personalised medicine. Many adult mesenchymal stem/progenitor cells (MSC) or pluripotent derivatives are being assessed simultaneously in preclinical trials for their potential treatment applications in chronic and degenerative human diseases. Endometrial mesenchymal stem/progenitor cells (eMSC) have been identified as clonogenic cells that exist in unique perivascular niches within the uterine endometrium. Compared with MSC isolated from other tissue sources, such as bone marrow and adipose tissue, eMSC can be extracted through less invasive methods of tissue sampling, and they exhibit improvements in potency, proliferative capacity, and control of culture-induced differentiation. In this review, we summarize the potential cell therapy and tissue engineering applications of eMSC in pelvic organ prolapse (POP), emphasising their ability to exert angiogenic and strong immunomodulatory responses that improve tissue integration of novel surgical constructs for POP and promote vaginal tissue healing.

show abstract

Section: Pelvic Organ Prolapsementioning

confidence: 99%

Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse

Hennes

Rosamilia

Werkmeister

et al. 2021

JPM

View full text Add to dashboard Cite

show abstract

“…Alongside PP meshes, other meshes are mono-/multifilament type formation and fabricated using either weaving or knitting processes ( Figure 2 ) [ 31 , 32 ]. The different types of meshes appear with different filament types ( Figure 2 ), and varying pore sizes and stiffness, such as: type I (macroporous PP meshes, >75 µm, Prolene, Gynemesh, Marlex and Restorelle (coloplast); Ultrapro; type II (microporous multifilament Polytetrafluroethylene (eTFE) meshes, <10 mm, such as Gore Tex); type III (macroporous multifilament meshes or with microporous, Vypro II, eTFE (Teflon), Surgipro, Mersilene, and Parietex); and type IV (hypo-microporous meshes, <1 mm) [ 19 , 31 , 32 , 33 ]. These were the first synthetic meshes used for POP and are synthesised with the presupposition of better tissue integration, increased collagen production, and with the aim of increasing tensile strength and elastic modulus of vaginal tissue.…”

Section: Pelvic Organ Prolapse and Non-degradable Biomaterials Meshmentioning

confidence: 99%

“…However, following complaints and FDA warnings during the last decade, growing evidence has shown that the risk and adverse effects of these meshes outweighed its benefits. Unacceptable adverse events including the exposure/erosion [ 32 , 37 ] of mesh ( Figure 3 ), pain, and infection occurred in up to 10–42% of surgeries, resulting in market withdrawal and banning of PP-based transvaginal meshes in Australia, New Zealand, the UK, and more recently in the USA [ 3 ]. The mismatch between the biomechanical properties of PP mesh and vaginal tissue impedes efficient tissue integration, which allows the mesh to move through tissue layers and become exposed (in vagina) or erode into other organs [ 39 , 40 ].…”

Section: Pelvic Organ Prolapse and Non-degradable Biomaterials Meshmentioning

confidence: 99%

“…Recently, surgical reconstruction has used various non-degradable polymers, particularly polypropylene (PP)-based macroporous lightweight monofilament commercial meshes, to augment pelvic floor reconstruction surgeries. Alongside PP meshes, other meshes are mono-/multifilament type formation and fabricated using either weaving or knitting processes (Figure 2) [31,32]. The different types of meshes appear with different filament types (Figure 2), and varying pore sizes and stiffness, such as: type I (macroporous PP meshes, >75 µ m, Prolene, Gynemesh, Marlex and Restorelle (coloplast); Ultrapro; type II (microporous multifilament Polytetrafluroethylene (eTFE) meshes, <10 mm, such as Gore Tex); type III (macroporous multifilament meshes or with microporous, Vypro II, eTFE (Teflon), Surgipro, Mersilene, and Parietex); and type IV (hypo-microporous meshes, <1 mm) [19,[31][32][33].…”

Section: Biomaterials Meshes In Pop Reconstructive Surgeriesmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction

et al. 2020

View full text Add to dashboard Cite

Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term.

show abstract

“…The use of an absorbable polyglactin mesh (Vicryl) to correct vaginal wall prolapse has shown little benefit (42%), and the use of a synthetic permanent polypropylene mesh for vaginal repair has shown a mesh erosion rate of 18% 2 , de novo urgency rate of 20%, and dyspareunia of 22% postoperatively. In pelvic floor reconstruction cases, the increase of the mesh erosion or infection rate fourfold when the mesh was introduced vaginally in comparison to the abdominal route 3 .…”

Section: Introductionmentioning

confidence: 99%

Application of Gamma Irradiated Amniotic Membrane as a Scaffold in Surgical Repair of Vaginal Wall Prolapse.

Elkassas

Moussa

farhan

et al. 2022

Al-Azhar International Medical Journal

View full text Add to dashboard Cite

show abstract

Host Response to Biomaterials for Pelvic Floor Reconstruction

Cited by 7 publications

References 120 publications

Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse

Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse

Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction

Application of Gamma Irradiated Amniotic Membrane as a Scaffold in Surgical Repair of Vaginal Wall Prolapse.

Contact Info

Product

Resources

About