A brief history of immunotherapy for breast cancer is presented, with emphasis on how theories developed as the field of immunology became more sophisticated. Non-specific therapies, such as Bacillus Calmette-Guérin, levamisole, interferon, interleukin, and others are reviewed. A form of cell-specific immunotherapy is then presented, and some current results are summarized. Problems and proposals for the future development of immunotherapy for breast cancer are then presented.