Host–pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: The role of CCL2 genetic variants

Alonso-Villaverde, Carlos; Aragonès, Gerard; Beltrán‐Debón, Raúl; Fernández-Sender, Laura; Rull, Anna; Rodríguez-Sanabria, Fernando; Marsillach, Judit; Pardo-Reche, Pedro; Camps, Jordi; Joven, Jorge

doi:10.1016/j.cyto.2010.05.008

Cited by 13 publications

(7 citation statements)

References 40 publications

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“…Therefore, we may conclude that elevated plasma CRP concentration per se does not increase atrial fibrillation risk. Although we and other groups have previously found that CCL2 genotypes may have a significant influence on plasma CCL2 concentration under inflammatory conditions , this has not been previously assessed in patients with AF. Despite a significant effect for one of the CCL2 variants, our data suggest that genotype combinations do not associate with a sufficient increase in plasma CCL2 to be instrumental in a Mendelian randomization study.…”

Section: Discussionmentioning

confidence: 68%

The relevance of the association between inflammation and atrial fibrillation

Alegret

Aragonès

Elosúa

et al. 2013

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 68%

The relevance of the association between inflammation and atrial fibrillation

Alegret

Aragonès

Elosúa

et al. 2013

Eur J Clin Investigation

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“…According to our data, this should be done in a sample with same ethnic origin and a sample size only achievable in multicenter-multicohort studies. The impact of population stratification in this study is unlikely because in our population sample this has been already assessed empirically by analyzing more than 25 unlinked single-nucleotide polymorphisms (SNPs) in several association studies spanning a range of disease states [35-39] and cases selected under the same circumstances.…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism

et al. 2011

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BackgroundThe recently observed association between the APOC3-related rs10892151 polymorphism and serum triglyceride levels has prompted us the possibility to explore whether this genetic variant may play a major role in human immunodeficiency virus (HIV)/antiretroviral therapy-induced dyslipidemia.MethodsWe determined the rs10892151 genotype distribution and serum apolipoprotein (apo) C-III concentration in a group of HIV-infected patients (n = 208) and in a group of age and sex-matched healthy volunteers (n = 200). Circulating lipid and lipoprotein levels were followed for 12 months after antiretroviral treatment initiation in the HIV-infected group.ResultsThere were no significant variations in the frequency of the A allele between the healthy and HIV-infected groups (7.5 vs. 8.6%, respectively; p = 0.7); additionally, the A allele was not related to serum apo C-III concentration. However, among patients receiving protease inhibitor (PI) treatment, carriers of the A allele had significantly increased serum triglyceride (5.76 ± 2.54 mmol/L) and total cholesterol (6.63 ± 2.85 mmol/L) concentrations together with depressed levels of HDL-cholesterol (0.75 ± 0.3 mmol/L) when compared with patients not carrying the allele (2.43 ± 1.32, 5.2 ± 2.17 and 1.24 ± 0.4 mmol/L, respectively) at the end of the study. This effect was only evident for HDL-cholesterol concentration when patients were treated with non-nucleoside reverse transcriptase inhibitors (1.05 ± 0.4 vs. 1.28 ± 0.4 mmol/L).ConclusionsThe A allelic variant of the rs10892151 polymorphism is not associated with serum apo C-III concentration, but predisposes HIV-infected patients to less favorable lipid profile, particularly in those patients treated with PIs.

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“…No genotypes tested affected chemokine levels or disease status. The panel of SNPs were selected from published papers [27][28][29][30][31][32][33][34]. All were associated with inflammatory disorders or with a change in chemokine levels in vivo or in vitro.…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Study of the Effects of ART on Plasma Chemokine Levels in Malaysian HIV Patients

et al. 2011

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Objectives: Chemokines influence the migration of leukocytes to secondary lymphoid tissue and sites of inflammation. In HIV patients, they are implicated in inflammatory complications of antiretroviral therapy (ART), notably Immune Reconstitution Disease (IRD) and Sensory Neuropathy (SN). However most chemokines have not been monitored as patients begin ART or correlated with IRD and SN. Methods: Plasma chemokine levels were assessed longitudinally using commercial ELISAs in 69 patients treated in Kuala Lumpur, Malaysia. Plasma was available at baseline and after 6, 12, 24 and 48 weeks on ART. Chemokine genotypes were assessed using allele-specific fluorescent probes. IRD were diagnosed in 15 patients. 30 patients were screened for SN using the ACTG BPNS tool after six months on ART. SN was detected in 8 patients. Results: Plasma CXCL10 levels decreased on ART compared to baseline (p = 0.002–0.0001), but remain higher than healthy controls (p ≤ 0.0001). The decline was clearer in patients without IRD. CCL5 levels rose on ART but remained similar to controls. CCL2 levels were higher in patients than controls after week 12. Plasma chemokine levels were not affected by CD4+ T-cell counts or any genotypes tested. Several patients with SN displayed higher CCL5 levels throughout therapy compared to patients without neuropathy. Levels of other chemokines and chemokine genotypes were not associated with SN. Conclusions: Chemokines are differentially affected by ART. CXCL10 and CCL5 may influence IRD and CCL5 warrants further investigation for an effect in SN. These trends are not influenced by chemokine genotypes investigated here.

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Host–pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: The role of CCL2 genetic variants

Cited by 13 publications

References 40 publications

The relevance of the association between inflammation and atrial fibrillation

The relevance of the association between inflammation and atrial fibrillation

Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism

A Longitudinal Study of the Effects of ART on Plasma Chemokine Levels in Malaysian HIV Patients

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