The relevance of the association between inflammation and atrial fibrillation

Alegret, Josep M.; Aragonès, Gerard; Elosúa, Roberto; Beltrán‐Debón, Raúl; Hernández-Aguilera, Anna; Romero-Menor, César; Camps, Jordi; Joven, Jorge

doi:10.1111/eci.12047

Cited by 29 publications

(20 citation statements)

References 41 publications

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“…[ 19 ] were the first to show the relationship between AF and inflammation in CABG patients. More recent studies showed an increase in CRP and IL-6 levels in occurrence and presence of AF [ 20 ]. Dernellis et al .…”

Section: Discussionmentioning

confidence: 99%

Do preoperative C-reactive protein and mean platelet volume levels predict development of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting?

Şaşkın¹,

Düzyol²,

Aksoy³

et al. 2016

pwki

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IntroductionAtrial fibrillation (AF) after coronary artery bypass grafting (CABG) operation is associated with increased risk of prolonged hospitalisation, health expenses and adverse clinical outcomes.AimTo investigate the relationship of atrial fibrillation after an isolated coronary artery bypass operation with levels of mean platelet volume and C-reactive protein.Material and methodsAmong 1240 patients who underwent operations for isolated coronary artery bypass grafting with cardiopulmonary bypass between January 2007 and May 2014, 1138 (91.8%) patients with preoperative normal sinusal rhythm were enrolled in the study. Patients were assigned to group 1 (n = 294) comprising patients who developed atrial fibrillation in the first 72 postoperative hours or group 2 (n = 844) comprising patients who remained in normal sinusal rhythm in the postoperative period.ResultsThe incidence of postoperative atrial fibrillation was 25.8%. The preoperative mean platelet volume (fl) and C-reactive protein (mg/dl) values in group 1 were 9.1 ±0.5 and 1.1 ±0.9 respectively, while these values were 8.3 ±0.6 and 0.5 ±0.3 respectively in group 2, which was statistically significant (p = 0.0001). Length of stay in the hospital (p = 0.0001) was higher in group 1. The values of mean platelet volume (fl) and mean C-reactive protein (mg/dl) were 9.9 ±0.9 and 30.9 ±3.4 respectively in group 1, while the values of mean platelet volume (fl) and mean C-reactive protein (mg/dl) were 8.8 ±0.6 and 24.9 ±4.8 respectively in group 2 (p = 0.0001 for mean platelet volume, p = 0.0001 for C-reactive protein). The difference between the groups was statistically significant in terms of postoperative neurologic events (p = 0.0001) and hospital mortality (p = 0.001). Increased C-reactive protein and mean platelet volume levels were found to be independent predictors of postoperative atrial fibrillation.ConclusionsIn our study, elevated preoperative mean platelet volume and C-reactive protein levels were associated with development of postoperative atrial fibrillation.

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Section: Discussionmentioning

confidence: 99%

Do preoperative C-reactive protein and mean platelet volume levels predict development of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting?

Şaşkın¹,

Düzyol²,

Aksoy³

et al. 2016

pwki

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“…In our case, we speculated that gallium-67 SPECT/CT revealed diffuse inflammation in the left atrium, which was useful for understanding that temporary inflammation due to confined myocarditis in the left atrium caused paroxysmal atrial fibrillation. Recently, associations between cardiac inflammation and atrial fibrillation have been reported [11], and inflammatory cells such as macrophages are recruited across atrial endocardium in atrial fibrillation [12]. We think gallium-67 accumulation in the left atrium is due to acute myocarditis because the serum antibody titer of cytomegalovirus was elevated in a few weeks, but we cannot deny the possibility that it is due to an idiopathic infiltration of inflammatory cells, which is considered to be one of the causes of atrial fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Gallium-67 Accumulation in the Left Atrial Wall Detected Using SPECT/CT Fusion Images

Kotani

Kawabe

Higashiyama

et al. 2016

Case Reports in Radiology

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Gallium-67 scintigraphy is useful for detecting active inflammation. We show a 66-year-old female patient with atrial fibrillation and diffuse thickening of the left atrial wall due to acute myocarditis, who presented diffuse abnormal accumulation of gallium-67 in the left atrium on single photon emission computed tomography/computed tomography (SPECT/CT) fusion images. In the second gallium-67 scan 2 months after the first scintigraphy, the abnormal accumulation in the heart was no longer visible. Gallium-67 SPECT/CT images helped understanding the disease condition that temporary inflammation in the left atrium caused atrial fibrillation.

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“…To elucidate the role of circulating inflammatory factors in atrial fibrillation, Wu et al conducted a meta-analysis based on observational studies [ 114 ] and evidenced that the presence of increased inflammation molecules (CRP, IL-6, and TNF- α ) was significantly associated with a greater AF risk in the general population. High levels of CRP, CCL2, and CXCL8 among patients with AF were found by several investigators [ 115 , 116 ]. Notably, elevated levels of CXCL8 detected in patients with permanent AF but not in patients with paroxysmal AF suggested a link between low-grade inflammatory reaction and long-lasting AF [ 116 ].…”

Section: Inflammation Chemokines and Cardiac Arrhythmiasmentioning

confidence: 92%

Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems

Dusi

Ghidoni

Ravera

et al. 2016

Mediators of Inflammation

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Among the chemokines discovered to date, nineteen are presently considered to be relevant in heart disease and are involved in all stages of cardiovascular response to injury. Chemokines are interesting as biomarkers to predict risk of cardiovascular events in apparently healthy people and as possible therapeutic targets. Moreover, they could have a role as mediators of crosstalk between immune and cardiovascular system, since they seem to act as a “working-network” in deep linkage with the autonomic nervous system. In this paper we will describe the single chemokines more involved in heart diseases; then we will present a comprehensive perspective of them as a complex network connecting the cardiovascular system to both the immune and the autonomic nervous systems. Finally, some recent evidences indicating chemokines as a possible new tool to predict cardiovascular risk will be described.

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The relevance of the association between inflammation and atrial fibrillation

Cited by 29 publications

References 41 publications

Do preoperative C-reactive protein and mean platelet volume levels predict development of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting?

Do preoperative C-reactive protein and mean platelet volume levels predict development of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting?

Diffuse Gallium-67 Accumulation in the Left Atrial Wall Detected Using SPECT/CT Fusion Images

Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems

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