Host Organisms:<i>Clostridium acetobutylicum</i>/<i>Clostridium beijerinckii</i>and Related Organisms

Bengelsdorf, Frank R.; Flitsch, Stefanie K.; Linder, Sonja; Schiel-Bengelsdorf, Bettina; Stegmann, Benjamin A.; Krabben, Preben; Green, Edward; Zhang, Ying; Minton, Nigel P.; Dürre, Peter

doi:10.1002/9783527807796.ch9

Cited by 4 publications

(4 citation statements)

References 143 publications

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“…In 2014, Green Biologics acquired the assets of Central MN Ethanol Co-op LLC in Little Falls, MN, USA, including a 65-ktpy ethanol plant. The plant was adapted to produce approximately 30 ktpy of acetone and butanol using corn starch and has the flexibility to utilize wood-based lignocellulosic feedstocks [298]. While the production of butanol from lignocellulose has reached industrial scale, its profitability, in the long run, remains to be proven.…”

Section: Opportunities To Produce Bio-based Chemicals Alongside Cellumentioning

confidence: 99%

A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol

Rosales-Calderon

Arantes

2019

Biotechnol Biofuels

387

255

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The demand for fossil derivate fuels and chemicals has increased, augmenting concerns on climate change, global economic stability, and sustainability on fossil resources. Therefore, the production of fuels and chemicals from alternative and renewable resources has attracted considerable and growing attention. Ethanol is a promising biofuel that can reduce the consumption of gasoline in the transportation sector and related greenhouse gas (GHG) emissions. Lignocellulosic biomass is a promising feedstock to produce bioethanol (cellulosic ethanol) because of its abundance and low cost. Since the conversion of lignocellulose to ethanol is complex and expensive, the cellulosic ethanol price cannot compete with those of the fossil derivate fuels. A promising strategy to lower the production cost of cellulosic ethanol is developing a biorefinery which produces ethanol and other high-value chemicals from lignocellulose. The selection of such chemicals is difficult because there are hundreds of products that can be produced from lignocellulose. Multiple reviews and reports have described a small group of lignocellulose derivate compounds that have the potential to be commercialized. Some of these products are in the bench scale and require extensive research and time before they can be industrially produced. This review examines chemicals and materials with a Technology Readiness Level (TRL) of at least 8, which have reached a commercial scale and could be shortly or immediately integrated into a cellulosic ethanol process.

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Section: Opportunities To Produce Bio-based Chemicals Alongside Cellumentioning

confidence: 99%

A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol

Rosales-Calderon

Arantes

2019

Biotechnol Biofuels

387

255

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“…Activated sporulation transcriptional regulator protein, Spo0A, inactivates AbrBs via phosphorylation. The Spo0A protein regulates sporulation and solventogenesis by activating genes (ctfA-ctfB, adc, ptb, adhE) that modulate acid and ABE production in Clostridium species (Figures 1 and 2) [63][64][65][66]. The activation is facilitated by Spo0A binding to the 0A boxes upstream of the promoters of genes involved in ABE production.…”

Section: Regulatory Interplay Between σ54-mediated Regulation and The...mentioning

confidence: 99%

Molecular Markers and Regulatory Networks in Solventogenic Clostridium Species: Metabolic Engineering Conundrum

Olorunsogbon,

Okonkwo,

Ezeji

2024

Fermentation

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Solventogenic Clostridium species are important for establishing the sustainable industrial bioproduction of fuels and important chemicals such as acetone and butanol. The inherent versatility of these species in substrate utilization and the range of solvents produced during acetone butanol–ethanol (ABE) fermentation make solventogenic Clostridium an attractive choice for biotechnological applications such as the production of fuels and chemicals. The functional qualities of these microbes have thus been identified to be related to complex regulatory networks that play essential roles in modulating the metabolism of this group of bacteria. Yet, solventogenic Clostridium species still struggle to consistently achieve butanol concentrations exceeding 20 g/L in batch fermentation, primarily due to the toxic effects of butanol on the culture. Genomes of solventogenic Clostridium species have a relatively greater prevalence of genes that are intricately controlled by various regulatory molecules than most other species. Consequently, the use of genetic or metabolic engineering strategies that do not consider the underlying regulatory mechanisms will not be effective. Several regulatory factors involved in substrate uptake/utilization, sporulation, solvent production, and stress responses (Carbon Catabolite Protein A, Spo0A, AbrB, Rex, CsrA) have been identified and characterized. In this review, the focus is on newly identified regulatory factors in solventogenic Clostridium species, the interaction of these factors with previously identified molecules, and potential implications for substrate utilization, solvent production, and resistance/tolerance to lignocellulose-derived microbial inhibitory compounds. Taken together, this review is anticipated to highlight the challenges impeding the re-industrialization of ABE fermentation, and inspire researchers to generate innovative strategies for overcoming these obstacles.

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“…As this bacterium also produces butanol and ethanol, the term HBE (hexanol, butanol, ethanol) fermentation was introduced by Fern andez-Naveira et al (2017). HBE fermentation is deduced from ABE (acetone, butanol, ethanol) fermentation that is known for solventogenic bacteria such Clostridium acetobutylicum and related bacteria (Bengelsdorf et al, 2017).…”

Section: Solid Biomassmentioning

confidence: 99%

“…(). HBE fermentation is deduced from ABE (acetone, butanol, ethanol) fermentation that is known for solventogenic bacteria such Clostridium acetobutylicum and related bacteria (Bengelsdorf et al ., ).…”

mentioning

confidence: 97%

Gas fermentation for commodity chemicals and fuels

Bengelsdorf

Dürre

2017

Microbial Biotechnology

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Host Organisms:Clostridium acetobutylicum/Clostridium beijerinckiiand Related Organisms

Cited by 4 publications

References 143 publications

A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol

A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol

Molecular Markers and Regulatory Networks in Solventogenic Clostridium Species: Metabolic Engineering Conundrum

Gas fermentation for commodity chemicals and fuels

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