Host Immune Response to Virus-Induced Tumors

Aoki, Toshihisa; Chieco‐Bianchi, Luigi; Plata, Ernest J.; Sendo, Fujiro; Hollis, Vincent W.; Kudo, Takuji

doi:10.1159/000395846

Cited by 2 publications

(2 citation statements)

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“…Yamamura et al, in preparation). In contrast, it has been shown for MSV-induced tumors that both T-and non-T-cells with specific cytotoxicity (Lamon et al, 1973;Aoki et al, 1974;Senik et al, 1974), as well as macrophages with non-specific growth-inhibiting and suppressor activities (Kirchner et a/., 1975), can be found in the spleen and peripheral lymph nodes, and we have found (H. T. Holden, J. S. Haskill, and H. Kirchner, in preparation) that both the T-cell and macrophage populations are present within the tumor as well. Thus, further studies of host immune responses to tumors in situ and their relationship to peripheral immune reactivity, and correlation of the results from different systems, should enable investigators to determine the value of the peripheral response for diagnosis of human tumors and for prognosis.…”

Section: Figurementioning

confidence: 98%

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Host responses within solid tumors: Non‐thymus‐derived specific cytotoxic cells within a murine mammary adenocarcinoma

Haskill

Yamamura

Radov

1975

Intl Journal of Cancer

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The nature of host-derived, specifically cytotoxic cells infiltrating solid murine mammary adenocarcinomas (line T1699) was investigated. Cell suspensions obtained from enzymatically dispersed tumors were separated by sedimentation velocity. The host cell fraction was heterogeneous and contained T-lymphocytes, non-phagocytic cells bearing Fc receptors, eosinophils and monocytes. Host cells equivalent in size to small lymphocytes and bearing Fc receptors were found to be the predominant cell type responsible for colony inhibition. These colony-inhibiting cells were insensitive to lysis with either anti-theta or anti-IgG serum and complement; and they were specific both in their induction and in their mediation and in their mediation of cytotoxicity. Host cells made up the predominant population in spontaneously regressive tumors but only a minor component in progressive tumors, and they were totally absent from progressive tumors in X-irradiated animals.

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Section: Figurementioning

confidence: 98%

“…in vitro cytotoxicity and in vivo adoptive transfer of immunity indicate that T-cell activity is a major factor in tumor rejection (Gorczynski, 1974; Rollinghoff and Wagner;1973; Plata et al, Cerottini and Brunner (1974) and Aoki et a/. (1974) for general reviews).…”

Section: Figurementioning

confidence: 99%