Host–Guest Interactions in Fe(III)-Trimesate MOF Nanoparticles Loaded with Doxorubicin

Anand, Resmi; Borghi, Francesco; Manoli, Francesco; Manet, Ilse; Agostoni, Valentina; Reschiglian, Pierluigi; Gref, Ruxandra; Monti, Sandra

doi:10.1021/jp503809w

Cited by 124 publications

(85 citation statements)

References 67 publications

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“…One possible explanation is the alkalinity of fluorescein disodium salt, which will lead to concentration-dependent changes in pH. Electrostatic interactions between charged molecules or “crosslinking” of MOF NPs by fluorescein molecules, as has been found for, e.g., doxorubicin [55] might also contribute to this effect. In order to examine these possibilities more closely, we performed DLS and concurrent zeta-potential experiments on suspensions of MOF-NPs in water.…”

Section: Resultsmentioning

confidence: 99%

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

et al. 2017

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Metal-organic framework nanoparticles (MOF NPs) are promising guest-host materials with applications in separation, storage, catalysis, and drug delivery. However, on-and off-loading of guest molecules by porous MOF nanostructures are still poorly understood. Here we study uptake and release of fluorescein by two representative MOF NPs, MIL-100(Fe) and MIL-101(Cr). Suspensions of these MOF NPs exhibit well-defined size distributions and crystallinity, as verified by electron microscopy, dynamic light scattering, and X-ray diffraction. Using absorbance spectroscopy the equilibrium dissociation constants and maximum numbers of adsorbed fluorescein molecules per NP were determined. Time-resolved fluorescence studies reveal that rates of release and loading are pH dependent. The kinetics observed are compared to theoretical estimates that account for bulk diffusion into NPs, and retarded internal diffusion and adsorption rates. Our study shows that, rather than being simple volumetric carriers, MOF-NPs are dominated by internal surface properties. The findings will help to optimize payload levels and develop release strategies that exploit varying pH for drug delivery.

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Section: Resultsmentioning

confidence: 99%

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

et al. 2017

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“…26 However, there are very few papers on characterization of adsorption of aromatic and heterocyclic compounds in solution 27 or titration of adsorbate in solution with the use of fluorescence spectroscopy. 28 Direct experimental determination of the type of chemical bonding in the "host−guest" adsorption complexes of the MOFs and aromatic hydrocarbons or aromatic N-heterocyclic compounds was not reported by fluorescence spectroscopy, to our knowledge. Further, fluorescence spectroscopy is well suited to study the MOFs 29,30 and mechanisms of adsorption on the MOFs, but the origin of the fluorescence from many MOFs is not known.…”

Section: Introductionmentioning

confidence: 84%

Fluorescence of A100 MOF and Adsorption of Water, Indole, and Naphthalene on A100 by the Spectroscopic, Kinetic, and DFT Studies

2015

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Metal−organic frameworks (MOFs) are promising materials for adsorption and separations. It is important to understand the details of chemical bonding between the adsorbate and structural units in the MOFs. In A100 MOF, the near-UV− visible fluorescence is found to be the intralinker fluorescence. Naphthalene and indole form the stoichiometric "host-guest" π−π adsorption complexes with A100 that contain one adsorbate molecule per two BDC linkers, and adsorption of indole causes a strong quenching of the intralinker fluorescence. The excitation wavelength dependent steadystate fluorescence spectra, the nanosecond time-resolved fluorescence spectra, and DFT calculations indicate the strong π−π interactions between adsorbed indole and naphthalene and aromatic ring of the BDC linker, as well as hydrogen bonding between adsorbed indole and COO group of the linker. Activated A100 adsorbs up to four water molecules per BDC linker. Kinetic study of adsorption of naphthalene and indole from n-alkane on hydrated A100 yields the preferential adsorption of indole as determined by the in-situ time-dependent fluorescence spectroscopy and complementary ex-situ UV−vis absorption spectroscopy.

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“…Due to the sieving effect, the sizes of windows can make the suitable drug molecules go through the pores [5]. A large number of reported PMOFs exhibit high drug delivery [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A 3D polyhedral metal–organic framework as drug carrier for controllable release

Zhou¹,

Wang²,

Wu³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT. A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]•12H2O•7DMA}(1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

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Host–Guest Interactions in Fe(III)-Trimesate MOF Nanoparticles Loaded with Doxorubicin

Cited by 124 publications

References 67 publications

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

Fluorescence of A100 MOF and Adsorption of Water, Indole, and Naphthalene on A100 by the Spectroscopic, Kinetic, and DFT Studies

A 3D polyhedral metal–organic framework as drug carrier for controllable release

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