Host-guest inclusion system of oleanolic acid with methyl-β-cyclodextrin: Preparation, characterization and anticancer activity

Ren, Yufeng; Liu, Ying; Niu, Raomei; Liao, Xiali; Zhang, Jihong; Yang, Bo

doi:10.1016/j.molstruc.2016.03.071

Cited by 18 publications

(2 citation statements)

References 37 publications

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“…The inclusion complexation significantly enhanced the water solubility of OA to 8.2 mg/mL. The inclusion complex demonstrated significant enhancement of the in vitro cytotoxicity compared to native OA, with IC50 values of 8.89, 7.89, and 5.77 μM on the human cancer cell lines HepG2, HT29, and HCT116, respectively, as determined by the MTT assay [ 169 ].…”

Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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The growing interest in oleanolic acid (OA) as a triterpenoid with remarkable health benefits prompts an emphasis on its efficient use in pharmaceutical research. OA exhibits a range of pharmacological effects, including antidiabetic, anti-inflammatory, immune-enhancing, gastroprotective, hepatoprotective, antitumor, and antiviral properties. While OA demonstrates diverse pharmacological effects, optimizing its therapeutic potential requires overcoming significant challenges. In the field of pharmaceutical research, the exploration of efficient drug delivery systems is essential to maximizing the therapeutic potential of bioactive compounds. Efficiently delivering OA faces challenges, such as poor aqueous solubility and restricted bioavailability, and to unlock its full therapeutic efficacy, novel formulation strategies are imperative. This discussion thoroughly investigates different approaches and advancements in OA drug delivery systems with the aim of enhancing the biopharmaceutical features and overall efficacy in diverse therapeutic contexts.

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Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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“…The complexes of CD and triterpenic acids were prepared according to several reported studies with minor modifications (Gao et al, 2016;Ren et al, 2016). In general, 30% β-CD (30 g β-CD dissolved in 100 mL water) was used for forming the inclusion complexes.…”

Section: β-Cd Inclusion Complexes Of Triterpenic Acidsmentioning

confidence: 99%

Development of a facile and sensitive HPLC‐FLD method via fluorescence labeling for triterpenic acid bioavailability investigation

You

Zhao

et al. 2017

Biomedical Chromatography

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Triterpenic acids are widely distributed in many fruits and are known for their medicinal benefits. The study of bioavailability has been an important task for a better understanding of the triterpenic acids. Although many methods based on fluorescence labeling for triterpenic acid determination have been established, these reported methods needed anhydrous conditions, which are not suitable for the convenient study of triterpenic acid bioavailability. Inspired by that, a versatile method, which overcomes the difficulty of the reported methods, has been first developed in this study. The novel method using 2-[12-benzo[b]acridin-5- (12H)-yl]-acetohydrazide (BAAH) as the fluorescence labeling reagent coupled with high-performance liquid chromatography with fluorescence detection was first developed for the study of triterpenic acid bioavailability. Furthermore, the labeling conditions have been optimized in order to achieve the best fluorescence labeling yield. Under the optimal conditions, the quantitative linear range of analytes was 2-1000 ng mL , and the correlation coefficients were >0.9998. The detection limits for all triterpenic acid derivatives were achieved within the range of 0.28-0.29 ng mL . The proposed method was successfully applied to the study of triterpenic acid bioavailability with excellent applicability and good reproducibility.

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Thermal Analyses of Cyclodextrin Complexes

Hădărugă

Bandur

Hădărugă

2018

Environmental Chemistry for a Sustainable World

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Host-guest inclusion system of oleanolic acid with methyl-β-cyclodextrin: Preparation, characterization and anticancer activity

Cited by 18 publications

References 37 publications

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Development of a facile and sensitive HPLC‐FLD method via fluorescence labeling for triterpenic acid bioavailability investigation

Thermal Analyses of Cyclodextrin Complexes

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