Host–guest chemistry of mesoporous silicas: precise design of location, density and orientation of molecular guests in mesopores

Sohmiya, Minoru; Saito, Kanji; Ogawa, Makoto

doi:10.1088/1468-6996/16/5/054201

Cited by 36 publications

(23 citation statements)

References 241 publications

(174 reference statements)

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“…[6][7][8][10][11][12] To the best of our knowledge, the efficacy of MSN carriers is decided by the structural features which determine the physicochemical properties of MSNs, including shape, size, pore characteristics, and surface chemistry. 13 Along with great progress in the structure control and multi-functionalization design of MSNs, various drug delivery formulations such as immediate drug delivery systems, sustained drug delivery systems, controlled drug delivery systems, targeted drug delivery systems, and stimuli-responsive drug delivery systems have been developed to improve the dissolution and bioavailability of poorly water-soluble drugs and enhance their therapeutic potential. [9][10][11][12]14,15 It should be noted that, a slight change in structural features of MSNs may not only significantly influence their host-guest interactions with drug molecules, but also impact the biological binding ability with tissues and cells.…”

Section: Introductionmentioning

confidence: 99%

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Hu¹,

Wang²,

Li³

et al. 2020

IJN

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Purpose: The purpose of this research was to study the basic physicochemical and biological properties regarding the application of L-tartaric acid modified chiral mesoporous silica nanoparticle (CMSN) as a drug carrier, and to explore the structure-property relationship of silica-based materials. Methods: CMSN with functions of carboxyl modification and chirality was successfully synthesized through co-condensation method, and the basic characteristics of CMSN, including morphology, structure, wettability, degradation, bio-adhesion and retention ability in gastrointestinal tract (GI tract) were estimated by comparing with non-functionalized mesoporous silica nanoparticles (MSN). Meanwhile, the biocompatibility and toxicity of L-tartaric modification were systematically evaluated both in vitro and in vivo through MTT cell viability assay, cell cycle and apoptosis assay, hemolysis assay, histopathology examination, hematology analysis, and clinical chemistry examination. Results: CMSN and MSN were spherical nanoparticles with uniform mesoporous structure. CMSN with smaller pore size and carboxyl functional groups exhibited better wettability. Besides, CMSN and MSN could dissolve thoroughly in simulated physiological fluids during a degradation period of 1-12 weeks. Interestingly, the in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion and retention ability in the GI tract were closely related to wettability. As expected, CMSN had faster degradation rate, higher mucosa-adhesion ability, and longer retention time. Particularly, CMSN improved the bio-adhesion property in both gastric mucosa and small intestinal mucosa, and prolonged the GI tract retention time to at least 12 h, which meant higher probability for absorption. The biocompatibility and toxicity examination indicated that CMSN was a kind of biocompatible bio-material with good blood compatibility and negligible toxicity, which is required for further applications in biological fields. Conclusion: CMSN with functions of carboxyl modification and chirality had superiority in terms of both physicochemical and biological properties. The in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion, and retention were closely related to wettability.

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Section: Introductionmentioning

confidence: 99%

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Hu¹,

Wang²,

Li³

et al. 2020

IJN

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“…Not only the electrostatic interactions, such interactions as hydrogen bonding and hydrophobic interactions are also included in the host-guest interactions and the structures are determined through cooperative effects. The comparison of the expandable two-dimensional nanospace of layered solids discussed in the present chapter and the fixed (but designable) nanospace of mesoporous silica as the hosts [167,168] is worth discussing. Multi-points and hetero host-guest interactions in a material need complicated multi-step syntheses and careful characterization, while it is a direction to make host-guest systems more sophisticated and artistic.…”

Section: Intraparticle Segregationmentioning

confidence: 99%

“…Though the pore is not expandable, the designable pore size of mesoporous materials has been utilized as host of various kinds of molecular species [2,[166][167][168]. Owing to their nanospace in the range of several nm and large pore volume, bulky organic species have been confined by using specific interactions.…”

Section: Intraparticle Segregationmentioning

confidence: 99%

“…In addition to the chemical approaches for the host-guest systems, the developments of new characterization tools and skills, and the progress in the purification and processing for practical applications, have continuously been done in both scientific fields and industry. For the huge variety of present and potential applications, the inorganic-organic interactions in various host-guest systems [166] should be examined further and the designed interface will play important role for the materials design for future [167,168].…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Inorganic–Organic Interactions

Okada

Ogawa

2017

Nanostructure Science and Technology

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Intercalation of guest species into layered materials is a way of constructing two-dimensionally ordered inorganic-organic molecular or supramolecular or hybrid assembly with unique microstructures controlled by host-guest and guestguest interactions [1][2][3][4][5][6][7][8][9]. One of the most unique characteristics of intercalation chemistry is the expansion of the interlayer space upon intercalation of guest species. The expanded interlayer space by the intercalation can be used to immobilize guest species further, since the space was geometrically and chemically modified to accommodate wider variety of guest species. This 'expandable' 2-dimensional nano-space is useful as a nano-vessel or nano-reaction environment for immobilizing various kinds of molecular functional species.The properties of intercalation compounds are largely affected by the population (or density or distance between adjacent species) of functional units and some useful functions are emerged only when appropriate population (nanostructure) is achieved. The interactions between host and guest have been investigated based on the structural consideration of resulting intercalation compounds (or interlayer microstructures). The characterization includes X-ray and electron diffraction and composition, chemical bonding between host and guest using vibrational spectroscopy, electronic states of the confined guests by electronic spectroscopy, strength of interactions using thermal analyses (desorption and decomposition), and more directly using advanced microscopies.

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“…Intercalation of photoactive species like organic dyes into layered solids has been investigated to understand the nature of host–guest systems and to prepare novel photofunctional supramolecular systems [ 8 ], because the characteristics of the photoprocesses are sensitive to the environment in which the photoactive species are located [ 9 ]. It has been found that solid–solid reactions are promising ways to intercalate organic guest species into the interlayer spaces of inorganic solids [ 2 , 9 , 10 ]. Solid–solid reactions are one of the most suitable techniques for intercalated processing due to the facile operation and the possibility to prepare compounds, which are not accessible from solutions, and so on [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Formation and optical properties of metal/10-hydroxybenzo[h]quinolone complexes in the interlayer spaces of magadiite by solid–solid reactions

et al. 2018

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Intercalation and in situ formation of three fluorescent complexes, Al(III)-, Cr(III)- and Cu(II)-10-hydroxybenzo[h]quinolone (M-HBQ, M = Al, Cr and Cu), in the interlayer spaces of magadiite (mag) were studied by solid–solid reactions between metal ions exchanged mags (M-mag, M = Al, Cr and Cu) and HBQ. Results show that the basal spacings of the intercalated composites increase after the intercalation of HBQ into M-mags. The amount of HBQ in the intercalated compounds is different due to the amount of metal ions and the diversification of coordination ability of metal ions, and the order of the coordination ability of these three metal ions is Cu2+ > Cr3+ > Al3+. The amount of the metal cations in the interlayer of mag is enough for the in situ complex formation of M-HBQ complexes. The slight shift of the absorption and luminescence bands of the complexes suggests the different microstructures, including molecular packing of the complexes in the interlayer spaces of mags, resulting that the host–guest interactions are formed. These findings show that the intercalation and in situ formation of M-HBQ complexes (M = Al, Cr and Cu) in the interlayer space of mag are successfully achieved in the current work.

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Host–guest chemistry of mesoporous silicas: precise design of location, density and orientation of molecular guests in mesopores

Cited by 36 publications

References 241 publications

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Inorganic–Organic Interactions

Formation and optical properties of metal/10-hydroxybenzo[h]quinolone complexes in the interlayer spaces of magadiite by solid–solid reactions

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