Host genetic risk factors for community-acquired pneumonia

Salnikova, Lyubov E.; Smelaya, Tamara V.; Мороз, В. В.; Голубев, А. М; Рубанович, А. В.

doi:10.1016/j.gene.2012.10.027

Cited by 24 publications

(40 citation statements)

References 59 publications

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“…There are also interesting reports of association of NOS3 polymorphisms with risk of community-acquired pneumonia (Salnikova et al, 2013). However, we consider that the translational potential of these findings may be most relevant for the problem of secondary pneumonia, specifically the increased susceptibility to bacterial lung infections that follows influenza.…”

Section: Discussionmentioning

confidence: 99%

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

Yang

Huang

Koziel

et al. 2014

eLife

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To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation, and better survival. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. Inhibitors and genetically altered mice identify a critical role for estrogen-mediated activation of lung macrophage nitric oxide synthase-3 (NOS3). Epidemiologic data show decreased hospitalization for pneumonia in women receiving estrogen or statins (known to activate NOS3). Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance, and increased host survival in both primary and secondary (post-influenza) pneumonia. The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza.DOI: http://dx.doi.org/10.7554/eLife.03711.001

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Section: Discussionmentioning

confidence: 99%

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

Yang

Huang

Koziel

et al. 2014

eLife

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“…A total of 12 eligible studies involving 5031 subjects were included in the meta-analysis. [7][8][9][10][11][12][13][14][15][16][17][18] The characteristics of selected studies are summarized in Table 1. There were four studies of Caucasians and seven studies of Asians.…”

Section: Discussionmentioning

confidence: 99%

“…5 So far, a number of studies have investigated the association of ACE I/D polymorphism with pneumonia. [7][8][9][10][11][12][13][14][15][16][17][18] Unfortunately, these epidemiological studies, performed in different countries, have yielded conflicting results, from strong links to no association. For instance, Morimoto et al indicated that the ACE DD genotype was associated with an increased risk of pneumonia and fatal pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

Nie

Zang

Chen

et al. 2014

J Renin Angiotensin Aldosterone Syst

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“…Therefore, it is highly likely that these differences are the result of a complex interplay between both host and pathogen genetic backgrounds together with nongenetic factors, such as those discussed above [182]. With the recent development of fast and affordable high-throughput sequencing techniques, more studies have begun to explore the contributions of host genetics in the context of pneumonia [183][184][185][186].…”

Section: Genetic Contributions To Pneumonia Risk and Severitymentioning

confidence: 99%

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

Silveyra¹,

Fuentes²,

Rivera³

2017

Contemporary Topics of Pneumonia

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Accumulating evidence indicates that exposure to air pollution is associated with increased mortality from respiratory disease. Exposure to ambient pollutants, such as ozone, particulate matter, sulfur dioxide, nitrogen dioxide, and other agents has been associated with decrease in lung function and immunity, and with increased rates of hospitalization for lung disease, including pneumonia. Furthermore, sex differences in frequency and severity of pulmonary disease and infection have been reported, suggesting a role of sex hormones in mediating these differences. Pneumonia, which is commonly caused by bacterial infection and subsequent lung inflammation leading to hospitalization and death, occurs at different rates in men and women. In this context, male and female hormones can have direct effects on the immunity system by binding to receptors in immune cells, and these responses can be modulated by environmental exposures. This chapter summarizes clinical, animal, and epidemiological studies linking exposure to air pollution and pneumonia in both males and females. Understanding sex-specific mechanisms in pneumonia pathogenesis and environmental responses can help in the development of more effective therapeutics and treatment options to reduce negative health outcomes in men and women.

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Host genetic risk factors for community-acquired pneumonia

Cited by 24 publications

References 59 publications

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

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