Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish

Catron, Tara R.; Keely, Scott P.; Brinkman, Nichole E.; Zurlinden, Todd J.; Wood, Charles E.; Wright, Justin; Phelps, Drake; Wheaton, Emily; Kvasnicka, Allison; Gaballah, Shaza; Lamendella, Regina; Tal, Tamara

doi:10.1093/toxsci/kfy261

Cited by 71 publications

(48 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these two articles did agree exactly on the toxicity and teratogenic effects of the bisphenols. In both articles, the potencies were described as BPAF > BPA > BPF > BPS [13]. Therefore, both articles were in agreement that BPS was the least toxic to developing zebrafish.…”

Section: Dietary Bps Exposure and Reproductionmentioning

confidence: 65%

“…Toxicity to each type of bisphenol was assessed after exposure at ten days post-fertilization. The potencies were reported as being BPAF > BPB > BPF = BPA > BPS [13]. Once again, BPS was shown to be the least toxic to the development of neuronal tissues.…”

Section: Dietary Bps Exposure and The Nervous Systemmentioning

confidence: 94%

“…The neural development of the hypothalamus was observed, and the article reported a 180% increase in altered neurogenesis for BPA and a 240% increase for BPS [15]. While zebrafish may seem to be a poor model for what may be happening in humans after dietary bisphenol exposure, the authors referenced above cite that many of the genes and critical pathways for organ formation are highly conserved among these two species, with 70% of these human genes being found in zebrafish [12][13][14][15]. The last three studies mentioned above are also discussed in the section about the nervous system and were therefore not included into the count of eighteen reproductive system articles.…”

Section: Dietary Bps Exposure and Reproductionmentioning

confidence: 99%

See 2 more Smart Citations

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

et al. 2020

View full text Add to dashboard Cite

In recent years, bisphenol analogues such as bisphenol S (BPS) have come to replace bisphenol A in food packaging and food containers, since bisphenol A (BPA) has been shown to leach into food and water, causing numerous negative health effects. Unfortunately, little or no research was done to determine the safety of these BPA-free products before they were marketed to the public as a healthier alternative. The latest studies have shown that some of these bisphenol analogues may be even more harmful than the original BPA in some situations. This article used a literature survey to investigate the bisphenol analogue BPS and compare it to BPA and other analogues with regards to increased obesity, metabolic disorders, cancer, and reproductive defects; among others. It was found that BPS works via different pathways than does BPA while causing equivalent obesogenic effects, such as activating preadipocytes, and that BPS was correlated with metabolic disorders, such as gestational diabetes, that BPA was not correlated with. BPS was also shown to be more toxic to the reproductive system than BPA and was shown to hormonally promote certain breast cancers at the same rate as BPA. Therefore, a strong argument may be made to regulate BPS in exactly the same manner as BPA.

show abstract

Section: Dietary Bps Exposure and Reproductionmentioning

confidence: 65%

Section: Dietary Bps Exposure and The Nervous Systemmentioning

confidence: 94%

Section: Dietary Bps Exposure and Reproductionmentioning

confidence: 99%

See 1 more Smart Citation

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Finally, analysis of larval behavior data is not standardized. Here, we opted to use a repeated measures ANOVA and parametric mixed model analysis to account for the complex data structure that contains multiple, repeated locomotor activity values for each animal over the 40-min testing period (Catron et al 2019a;Irons et al 2013;Phelps et al 2017;Stevens et al 2018). However, zebrafish behavior data are not normally distributed and may often be below the LOD.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Gaballah

Swank

Sobus

et al. 2020

Environ Health Perspect

Self Cite

255

149

View full text Add to dashboard Cite

BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is associated with developmental toxicity, prompting their replacement with short-chain and fluoroether compounds. There is growing public concern over the safety of replacement PFAS. OBJECTIVE: We aimed to group PFAS based on shared toxicity phenotypes. METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid (PFESA1), perfluorohexanesulfonic acid (PFHxS), perfluorohexanoic acid (PFHxA), perfluoro-n-octanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), or 0.4% dimethyl sulfoxide (DMSO) daily from 0-5 d post fertilization (dpf). At 6 dpf, developmental toxicity and developmental neurotoxicity assays were performed, and targeted analytical chemistry was used to measure media and tissue doses. To test whether aliphatic sulfonic acid PFAS cause the same toxicity phenotypes, perfluorobutanesulfonic acid (PFBS; 4-carbon), perfluoropentanesulfonic acid (PFPeS; 5-carbon), PFHxS (6-carbon), perfluoroheptanesulfonic acid (PFHpS; 7-carbon), and PFOS (8-carbon) were evaluated. RESULTS: PFHxS or PFOS exposure caused failed swim bladder inflation, abnormal ventroflexion of the tail, and hyperactivity at nonteratogenic concentrations. Exposure to PFHxA resulted in a unique hyperactivity signature. ADONA, PFESA1, or PFOA exposure resulted in detectable levels of parent compound in larval tissue but yielded negative toxicity results. GenX was unstable in DMSO, but stable and negative for toxicity when diluted in deionized water. Exposure to PFPeS, PFHxS, PFHpS, or PFOS resulted in a shared toxicity phenotype characterized by body axis and swim bladder defects and hyperactivity. CONCLUSIONS: All emerging fluoroether PFAS tested were negative for evaluated outcomes. Two unique toxicity signatures were identified arising from structurally dissimilar PFAS. Among sulfonic acid aliphatic PFAS, chemical potencies were correlated with increasing carbon chain length for developmental neurotoxicity, but not developmental toxicity. This study identified relationships between chemical structures and in vivo phenotypes that may arise from shared mechanisms of PFAS toxicity. These data suggest that developmental neurotoxicity is an important end point to consider for this class of widely occurring environmental chemicals.

show abstract

“…Exposure to BPA and BPA analogs in animal models such as rodents, zebrafish, rabbits, and dogs can affect the gut microbiota and have an impact on the development of metabolic diseases. Some studies have reported that there is a sexual dysmorphic effect [6,[29][30][31][32][33].…”

Section: Bpa and Analogsmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

View full text Add to dashboard Cite

Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

show abstract

Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish

Cited by 71 publications

References 57 publications

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Contact Info

Product

Resources

About