Host Defense Proteins on the Surface of Neonatal Skin: Implications for Innate Immunity

The Natural Antimicrobial Chromogranins/Secretogranins- Derived Peptides – Production, Lytic Activity and Processing by Bacterial Proteases

“…Still recently, the contribution of lysozyme to cutaneaous defense was subjected to debate since it was not detected in stratum corneum as well as in washing fluid. However, it was recently detected in skin wash of adults, and lysozyme concentration was 5 times higher in newborn skin than in adult (Walker et al, 2008), confirming its status of antimicrobial molecule, as well as giving it an important role in preventing infections in newborn children.…”

“…It is active against Gram-positive, Gram-negative bacteria and also against Candida albicans (Bellamy et al, 1993). This molecule was also detected in skin wash of adult and newborn children (Walker et al, 2008). Synthesized by melanocytes, cutaneous lactoferrin is an iron-binding protein with antibacterial properties due to its ability to sequester iron in biological fluids or to destabilize bacterial membranes, limiting microorganism proliferation and adhesion.…”

“…It has also immunomodulatory properties by up and down regulating immune cells involved in inflammatory processes (Legrand et al, 2005). The protective anti-inflammatory role of lactoferrin is due to its ability to bind free ferric ion acting as an anti-oxidant (Walker et al, 2008). It can bind to LPS and their receptors during an infection as well (Legrand et al, 2005).…”

Skin Care in Young Children: Innovative Approaches

“…Их уровни значительно увеличиваются при повреждении эпидермиса (раны) или при инфекциях кожи [41,42]. Другие белки, такие как лизоцим и лактоферрин, присут-ствуют в коже новорожденного в уровнях, превышающих значения взрослых более чем в пять раз [43].…”

“…Исследования демонстрируют положительный эффект от массажа с использованием масел [62]. Такие масла, как подсолнечное, сафлоровое, кунжутное и абри-косовое, содержат в составе жирные кислоты (особенно линолевую), которые обладают противовоспалительными эффектами [63] и увеличивают скорость образования эпидермального барьера [2].…”