Hospitalization Due to Complications From the Use of Analgesics, Antipyretics and Anti-Inflammatories in Brazil Between 2007 and 2021

Abstract

Introduction: Non -opioid analgesics and non-steroidal antiinflammatory drugs (NSAIDs) are among the most used drugs in the world, and are often used without a medical prescription. Objective: To describe the epidemiological profile of hospitalizations due to adverse effects due to the use of analgesics, antipyretics and anti-inflammatories in Brazil between 2007 and 2021. Methodology: This is a descriptive observational study, whose data were collected through the DataSUS platform. Collection started from the Hospital Information System (SIH), through hospital morbidity data by place of residence between January 2007 and December 2021. Results and Discussion: There were 688 hospitalizations due to adverse effects from the use of analgesics, antipyretics and antiinflammatories. The most affected region was the southeast with 44.33% of all cases in the country. The national average age group most affected is represented by two peaks: from one to four years of age and from 20 to 29. Although there is no difference between the number of hospitalizations of men and women, the female rate was approximately 25 %. The general mortality rate was 2.47 among hospitalized patients, however, this rate varied between private and public services, the latter being 70% higher. Conclusion:Greater awareness policies on the proper and rational use of medicines must be implemented. In addition, further investigation by the hospital team must be encouraged, in order to promote lower rates of adverse reactions in those patients who have had episodes of suspected complications before.