Hospitalisations for sickle‐cell disease in an <scp>A</scp>ustralian paediatric population

Teoh, Yvonne; Greenway, Anthea; Savoia, Helen; Monagle, Paul; Roy, John R.; Barnes, Chris

doi:10.1111/jpc.12018

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…In this study, pain crisis was the main reason for hospital admissions (93.3%), in accordance with similar percentages in other published reports [10,23,25,26]. Pain crisis, mainly due to a vaso-occlusive episode, is a main reason for hospital admissions for SCD patients [23,25,26,27,28]. Pain crisis either occurred suddenly (in 34.4% of patients), or was triggered by other factors such as extreme cold, hard work, heat and sun, psychological factors, and deficiency of ingested fluids, also in agreement with previous researches [4,9,24,29].…”

Section: Discussionsupporting

confidence: 91%

“…Results of this study shows that in only few patients’ pain relief occurred within 10 min, while most patients (75.6%) needed over 24 h to achieve complete pain relief. Average length of hospital stay varies from three days [27] to over 10 days [26], which make us wonder about patients claiming total pain relief within 24 h. In addition to the suffering of patients, this requires a longer stay at the hospital and thus extra costs. Furthermore, this causes inconveniences for the family or caretakers of the patient, particularly since most of the patients hail from poor families and come from distant villages and towns.…”

Section: Discussionmentioning

confidence: 99%

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Management of Sickle Cell Disease Pain among Adolescent and Pediatric Patients

et al. 2019

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Management of sickle cell pain in adolescent and pediatric patients is inadequate, and the employment of proper management guidelines and practices are highly variable among different regions and populations. APPT, the multidimensional adolescent pediatric pain tool, promotes optimal pain management and introduces best practical guidelines for pain management. The goal of this study is to assess pain and pain management among young patients diagnosed with sickle cell disease (SCD) by introducing the APPT as a tool for pain management, and analyze factors contributing to pain management. Information relevant to demographic data, SCD characteristics, APPT assessment, and satisfaction of patients regarding pain management were collected using a structured questionnaire. Results showed that SCD is highly associated with gender (p = 0.022), consanguinity (p = 0.012), and number of surgeries (p = 0.013). Most patients (58.9%) indicated the involvement of more than six body areas affected during pain crisis. Severe pain was described by more than half the patients (55.6%), while moderate pain was reported by 31.1%. Most patients described their pain by sensory, affective, and temporal words. The number of painful areas, pain intensity, and use of descriptive pain words was correlated and interpreted by age, BMI, school absence, and number of surgeries. Results of this study could provide guidance to healthcare providers to improve current practices for SCD pain management in order to improve health outcomes and patients’ satisfaction.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Management of Sickle Cell Disease Pain among Adolescent and Pediatric Patients

et al. 2019

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“…Pain is more common cause of hospitalization in high income countries accounting for up to two-thirds of hospitalizations. 26,27 The lower prevalence of hospitalization for pain is likely due to the elevated prevalence of fever. Malaria and bacterial infections are common causes of fever in people with SCA in sub-Saharan Africa.…”

Section: Discussionmentioning

confidence: 99%

Complications of sickle cell anaemia in children in Northwestern Tanzania

et al. 2016

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Objectives Tanzania has the 3rd highest birth rate of sickle cell anaemia (SCA) in Africa, but few studies describe severity of complications or available treatments, especially in North West Tanzania around Lake Victoria where the sickle gene is most prevalent. This is a report of the spectrum of clinical disease and range of interventions available at Bugando Medical Centre (Bugando) in North West Tanzania in Africa. Methods A cross-sectional study was carried out in Bugando between August 1, 2012 and September 30, 2012. Children (< 15 years old) with SCA attending Bugando were sequentially enrolled. A trained research assistant completed a Swahili questionnaire with the parent or guardian of each participant concerning demographic information, clinical features of disease, and treatments received. Results Among the 124 participants enrolled, the median age was 6 years [IQR 4-8.5], and only 13 (10.5%) were < 3 years old. Almost all participants (97.6%) had a prior history of a vaso-occlusive episode, 83 (66.9%) had prior acute chest syndrome, and 21 (16.9%) had prior stroke. In the preceding 12 months, 120 (96.8%) had been hospitalized, and a vaso-occlusive episode was the most common reason for hospitalization (35.5%). Prescriptions for folic acid (92.7%) and malaria prophylaxis (84.7%) were common, but only one had received a pneumococcal vaccine, and none had received hydroxyurea or prophylactic penicillin. Conclusion Children with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care.

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“…Causes of hospital admission have been studied in sickle cell disease 1,2 . However, only two reports (one from Iran and the other from Sardinia), limited to patients with TM, have previously described the causes of hospital admission in thalassemia patients 3,4 .…”

Section: To the Editormentioning

confidence: 99%