Hospitalisation rates and characteristics for adult and childhood immunoglobulin A vasculitis in Western Australia

Abstract

Hospitalisation rates for adults with IgAV now nearly equal those in children as adult IgAV leads to more complications .The sharp decline in childhood IgAV admissions suggests that confidence to manage children with IgAV outside the hospital setting has increased. This article is protected by copyright. All rights reserved.

Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio with Gastrointestinal Involvement of Immunoglobulin a Vasculitis

“… 1–4 However, higher risk of systemic complications in adults was found, among which most notable risk is the chronic renal failure and GI involvement. 2–4 Genetic factors, both abnormal innate and acquired immunity, inflammation, galactose-deficient IgA1 immunocomplexes, COVID-19 as well as anti-COVID vaccines are considered to be involved in the pathogenesis of IgAV. 11 , 16 Endothelial cells distribute on the inner surfaces of blood vessels as well as lymphatic vessels.…”

“… 1 Although it is relatively rare in adults, it leads to a worse clinical presentation and prognosis compared to children. 2–4 In addition to some patients only presented with skin purpura, IgAV patients may have different organs involved, which led to different prognosis accordingly 5 and gastrointestinal (GI) involvement represents major risk of mortality in acute adult IgAV and often shows severe hemorrhage and bowel perforation. 6 …”

“…1 Although it is relatively rare in adults, it leads to a worse clinical presentation and prognosis compared to children. [2][3][4] In addition to some patients only presented with skin purpura, IgAV patients may have different organs involved, which led to different prognosis accordingly 5 and gastrointestinal (GI) involvement represents major risk of mortality in acute adult IgAV and often shows severe hemorrhage and bowel perforation. 6 Increased levels of oxidative stress and inflammatory markers have been reported by several studies in IgAV patients, such as tumor necrosis factor ɑ (TNF-ɑ), interleukin 6 (IL-6), interleukin 1β (IL-1β), monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR) and CRP.…”

Navigating the initial diagnosis and management of adult IgA vasculitis: A review

“…5,41 Upper respiratory tract infection especially common, more common in fall and winter. 2,6,41 More often idiopathic, with precipitating factors identified in around a quarter of cases. 41 Drug implicated cases have been reported in the range of 12.5%-26%, whereas preceding infections have been described in 23%-35% of cases.…”

“…However, IgAV in adults might be more common than initially thought because of under-diagnosis, and essential differences exist between children and adults (Table I). [1][2][3][4][5][6][7] IgAV in adults is also associated with more severe disease, necessitating a greater focus on management. 8 Currently, the broad approach to the initial workup and management of IgAV is based on comorbidities, associated symptoms, and the approach and expertise of the clinician managing the patient at the time of diagnosis.…”