Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China

Nie, Yingli; Song, Zexing; Tao, Juan; Liu, Yang

doi:10.1007/s11596-021-2440-0

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…12 In addition to the vascular factor, endothelial injury as well as increased production of coagulation factors, and the enhanced activities of coagulation system (D-Dimer, Von Willebrand factor [VWF]) also contribute to the formation of thrombosis. 5,8,13 The gastrointes- cause relatively concentrated blood during the acute stage of the disease. In our case, high blood viscosity and hyperhemoglobinemia were prominent during the period of CVST, which indicated another possible risk factor for CVST.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the vascular factor, endothelial injury as well as increased production of coagulation factors, and the enhanced activities of coagulation system (D‐Dimer, Von Willebrand factor [VWF]) also contribute to the formation of thrombosis 5,8,13 . The gastrointestinal tract is often involved in CVST patients based on the systemic review.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated von Willebrand factor (vWF) antigen level and Factor VII were observed in the acute stage of IgAV 6 . Endothelial injury along with hypercoagulability contributes to the development of thrombosis, which is a rare complication in IgAV 7,8 . Here we report a case with central venous sinus thrombosis (CVST) related to IgAV and summarize the clinical features and imaging findings of this rare complication based on a literature review.…”

Section: Introductionmentioning

confidence: 97%

“…6 Endothelial injury along with hypercoagulability contributes to the development of thrombosis, which is a rare complication in IgAV. 7,8 Here we report a case with central venous sinus or arthralgia; (4) renal involvement, which will be defined as IgAV.…”

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confidence: 99%

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Venous sinus thrombosis in a case of immunoglobulin A vasculitis and a systemic review of literature

Zheng

Qian

Huang³

et al. 2022

Int J of Rheum Dis

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Immunoglobulin A vasculitis (IgAV) or Henoch-Schönlein purpura (HSP) is the most common systemic small-vessel vasculitis in children. It mainly involves the skin, joints, gut and glomeruli, and rarely can cause vasculitis in the central nervous system (CNS). 1,2 The incidence of IgAV is 3~26.7/100 000. 3 CNS involvement is only seen in a few case reports.The underlying mechanism of IgAV remains unknown. Studies have shown that IgAV occurs more frequently in autumn and winter than other seasons, which suggests climate-associated environmental factors (especially preceding infection) play a

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

mentioning

confidence: 99%

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Venous sinus thrombosis in a case of immunoglobulin A vasculitis and a systemic review of literature

Zheng

Qian

Huang³

et al. 2022

Int J of Rheum Dis

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Abdominal imaging and endoscopic characteristics of adult abdominal IgA vasculitis: a multicenter retrospective study

Gong,

Han,

Zhang

et al. 2024

Annals of Medicine

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Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis

Wang,

et al. 2024

BMC Nephrol

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Background The objective of this study is to investigate the clinical and pathological differences between patients with IgA nephropathy (IgAN) and IgA vasculitis associated nephritis (IgAVN). Methods A total of 253 patients with IgAN and 71 patients with IgAVN were retrospectively included in the study, and clinical and laboratory data were collected and analysed. Results Compared with IgAVN group, months from onset to kidney biopsy were significantly prolonged in IgAN patients because of the lack of obvious symptoms such as rash, abdominal symptoms, and joint pain (13.5 ± 26.6 vs. 10.2 ± 31.6 months, P = 0.007), and the levels of serum creatinine (92.3 ± 94.7 vs. 68.9 ± 69.2 µmol/L, P = 0.015) was higher and eGFR (99.1 ± 35.2 vs. 123.4 ± 41.8 mL/min/1.73m2, P < 0.001) was lower in IgAN group. The pathological results revealed that patients with IgAN have a greater degree of chronic kidney injury compared to patients with IgAVN. In addition, the levels of plasma D-Dimers (1415.92 ± 1774.69 vs. 496.78 ± 711.91 ng/mL, P < 0.001) and fibrinogen degradation products (FDP) (3.92 ± 4.73 vs. 1.63 ± 2.46 µg/mL, P = 0.001) were significantly higher in IgAVN patients than in IgAN patients. The deposition of fibrinogen in the renal tissues was more severe and the cumulative partial remission rate was higher in patients with IgAVN as compared to those with IgAN (P = 0.001). Conclusions In comparison, IgAN patients had poorer renal function, whereas IgAVN patients had more severe coagulation abnormalities. These findings provide a basis for the differentiation of the two diseases at an early stage.

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Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China

Cited by 3 publications

References 25 publications

Venous sinus thrombosis in a case of immunoglobulin A vasculitis and a systemic review of literature

Venous sinus thrombosis in a case of immunoglobulin A vasculitis and a systemic review of literature

Abdominal imaging and endoscopic characteristics of adult abdominal IgA vasculitis: a multicenter retrospective study

Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis

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