This study included only those that were categorized as general hospitals with emergency departments. Rehabilitation, geography, pediatric, long-term care, and federal government hospitals (Veterans and military hospitals) were excluded. For hospitals with multiple sites, the entry in Background and Purpose-The number of certified primary stroke centers (PSCs) have increased dramatically during the past decade in the United States We aimed to understand the factors affecting PSC distribution in the United States, including the impact of state stroke legislation. Methods-PSCs certified by national organization or state until December 2013 were searched from available databases. The proportion of PSC among short-term general hospitals in each state was calculated and factors affecting its distribution were analyzed. Results-By the end of 2013, the proportion of PSC varied from 4% to 100% among the 50 states and District of Columbia.The 18 states that had legislation in designating stroke centers and regulating stroke triage had higher PSC percentages (median, 43%; range, 13%-100%) than the remaining states (median, 13%; range, 4%-75%; P<0.001). State stroke legislation, urbanization, state economic output, and larger hospital size independently increased the likelihood of a hospital to be stroke certified. the American Hospital Association Database was used as the unit of 1 hospital. The proportion of PSC-certified hospitals among all hospitals was calculated. The Core Based Statistic Area assignment for each hospital was used as a marker of urbanization and was drawn from the American Hospital Association Database. Core-based statistical areas were defined by the US Office of Management and Budget as metropolitan division (a core with a population of at least 2.5 million with surrounding areas), metropolitan statistical area (urbanized area that has a population of at least 50 000 and surrounding areas), micropolitan statistical area (1 urban cluster that has a population of at least 10 000, but <50 000 and surrounding areas), and rural area. 12 We used the region designation by the US Census Bureau as Northeast, Midwest, South, and West.
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Statistical AnalysisThe data were analyzed using JMP 10.0 (SAS Inc, Cary, NC ). Eighteen states established legislation in designating stroke centers and some of them implemented policies for emergency medical services to route patients with acute stroke to PSC-certified hospitals. The legislation status in each state is shown in Table 1. States with stroke legislation had higher PSC proportion than those states with no stroke legislation (Figure 1). The percentage of PSC certified hospitals in states with no stroke legislation ranged from 4% in Wyoming to 75% in DC, with a median of 13% (Table I in the onlineonly Data Supplement). In the states with stroke legislation, the percentage of PSCs ranged from 13% in North Dakota to 100% in Delaware, with a median of 43% (P<0.001; Table I in the online-only Data Supplement). When the 50 states and the District of Columbia were stra...