Hospital routine analysis of penicillins, third-generation cephalosporins and aztreonam by conventional and high-speed high-performance liquid chromatography

Jehl, F.; Birckel, P.; Monteil, H.

doi:10.1016/0378-4347(87)80218-9

Cited by 65 publications

(17 citation statements)

References 19 publications

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“…Cefpiramide assay. Cefpiramide levels were determined by high-performance liquid chromatography (7). Calibration curves were established with cefpiramide-free fluids.…”

Section: Methodsmentioning

confidence: 99%

High hepatic excretion in humans of cefpiramide, a new cephalosporin

Jehl

Adloff

et al. 1988

Antimicrob Agents Chemother

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After intravenous administration of 1 g of cefpiramide, the biliary elimination of the drug was studied by using high-performance liquid chromatography. In five healthy volunteers, a mean peak concentration of 339 ± 107 (standard error of the mean) ,ug/ml was measured in aspirated duodenal fluid during h 2 after administration, and 1.2% of the dose given was recovered over a 4-h period. A maximal concentration of 1,161 ± 392 ,ug/ml was reached during h 2 in T-tube bile from 10 recently cholecystectomized patients, with a 24-h biliary recovery of 23.1%; urinary recovery over the same period averaged 49.4%. In 10 patients undergoing cholecystectomy, the concentrations in serum, choledochal bile, gallbladder bile, and gallbladder wall 1 h after cefpiramide administration were 157 ± 21, 1,726 ± 501, and 84 ± 33 ,ug/ml and 23 ± 4 ,ug/g, respectively. These figures represent the highest biliary concentrations attained so far with a beta-lactam antibiotic and are therefore a good prerequisite for treatment of biliary tract infections with cefpiramide.

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“…Cefpiramide assay. Cefpiramide levels were determined by high-performance liquid chromatography (7). Calibration curves were established with cefpiramide-free fluids.…”

Section: Methodsmentioning

confidence: 99%

High hepatic excretion in humans of cefpiramide, a new cephalosporin

Jehl

Adloff

et al. 1988

Antimicrob Agents Chemother

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“…Despite advances in antibiotic development, lower respiratory tract infections and their associated severe complications, such as metapneumonic empyema, are still major clinical problems (18). Appropriate antibiotic treatment is probably the most effective single measure for dealing with lower respiratory tract bacterial infections.…”

mentioning

confidence: 99%

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Tomaselli

Maier

Matzi

et al. 2004

Antimicrob Agents Chemother

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Until recently, information on antibiotic pharmacokinetic properties in infected human lung tissue was limited. We therefore studied a microdialysis-based approach for measurement of the penetration of meropenem into the extracellular space fluid of human pneumonic lung parenchyma. The lung penetration of meropenem was determined for seven patients with pneumonia and metapneumonic pleural empyema treated by decortication. Intraoperatively, two microdialysis probes were inserted into pneumonic lung tissue and one was inserted into healthy skeletal muscle for reference values.

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“…There are a number of liquid chromatographic methods reported in the literature for the individual assays of ceftriaxone in aqueous and biological sample [24][25][26][27][28][29]. Owens achieved chromatographic separation by using cetyltrimethylammonium bromide (0.01 M) as ion-pairing agent.…”

Section: Figmentioning

confidence: 99%

“…One method for the analysis of ceftriaxone in clinical microbiology in the biological fluids has been developed by the Knoeller et al, [27]. Nahata [28], Jehl and Birckel [29] also developed a method using phosphate buffer of pH 7 as a mobile phase. All of these methods consisted buffers combination as mobile phase.…”

Section: Figmentioning

confidence: 99%

Simultaneous Determination of Ceftriaxone Sodium and Statin Drugs in Pharmaceutical Formulations and Human Serum by Rp-HPLC

Sultana

Arayne

Shahzad

2010

J. Chil. Chem. Soc.

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An accurate, sensitive and least time consuming reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of ceftriaxone in the presence of statin drugs in formulation and human serum has been developed and validated. Chromatographic separation was conducted on prepacked Purospher Star, C18 (5 mm, 250 x 4.6 mm) column at room temperature using methanol:water:acetonitrile (70:15:20 v/v/v) as a mobile phase, pH adjusted at 2.8 with ortho-phosphoric acid and at a flow rate of 1.0 mL/minute, while UV detection was performed at 240 nm. The results obtained showed a good agreement with the declared content. The method shows good linearity in the range of 2.5-25 µg/mL with a correlation coefficient 0.9966 -0.9998 (inter-and intra-day RSD < 2 %).The limit of detection and quantification for ceftriaxone and statins in pharmaceutical formulation and serum were in the range 0.124 -1.006 µg/mL. Analytical recovery was >98.72 %. The proposed method may be used for the quantitative analysis of commonly administered statin's i.e. simvastatin, rosuvastatin atorvastatin and pravastatin alone or in combination with ceftriaxone from raw materials, dosage formulations and in serum. The established HPLC method is rapid, accurate and selective, because of its sensitivity and reproducibility.

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Hospital routine analysis of penicillins, third-generation cephalosporins and aztreonam by conventional and high-speed high-performance liquid chromatography

Cited by 65 publications

References 19 publications

High hepatic excretion in humans of cefpiramide, a new cephalosporin

High hepatic excretion in humans of cefpiramide, a new cephalosporin

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Simultaneous Determination of Ceftriaxone Sodium and Statin Drugs in Pharmaceutical Formulations and Human Serum by Rp-HPLC

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