Hospital morbidity among elderly patients, before and after influenza vaccination in the state of Paraná

Ferrer, Ana Lúcia Mendes; Marcon, Sônia Silva; Santana, Regina Helena Carlucci

doi:10.1590/s0104-11692008000500006

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…One study failed to demonstrate the effect of the vaccination in hospital admissions and mortality due to influenza-related causes, 14 another found a 26% reduction in mortality rates due to influenza and pneumonia, 2 and three studies point to an increase in influenza-related mortality rates 3,8,12 . Of the six studies analyzing hospital admissions, five found modest reductions in rates or number of hospitalizations, 6,11,15,19,31 and the previously cited one showed no effect of the vaccination 14 . A large part of this apparent conflict might be explained by the differences in the time frames that were compared, in the geographic regions studied, in the presence or absence of rate standardization, and also in the outcome variables defined.…”

Section: Discussionmentioning

confidence: 93%

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Effectiveness of the Brazilian influenza vaccination policy, a systematic review

Luna

Gattás

2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYSince 1999, Brazil has undertaken annual influenza vaccine campaigns, free of charge, targeting the elderly population, health professionals, and immune-deficient patients. We conducted a systematic review of literature in order to evaluate the effectiveness of the initiative. We used the keywords influenza, vaccine, Brazil and effectiveness to search the main databases. Thirty-one studies matched our inclusion and exclusion criteria. Influenza vaccine coverage among the elderly is high, though not as high as suggested by the official figures. Estimates on effectiveness are scarce. The majority come from ecological studies that show a modest reduction in mortality and hospital admissions due to influenza-related causes. Such reduction is not evident in the North and Northeastern states of Brazil, a finding that is probably related to the different seasonal pattern of influenza in equatorial and tropical regions. Brazilian epidemiologists still owe society better-designed studies addressing the effectiveness of influenza vaccine campaigns.

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Section: Discussionmentioning

confidence: 93%

“…Table 2 presents a summary of these studies. Seven studies analyzed mortality data time series, 2,3,8,12,18,21,26 while five analyzed hospital admissions data 6,11,15,19,31 . One study used both mortality and morbidity data 14 .…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of the Brazilian influenza vaccination policy, a systematic review

Luna

Gattás

2010

Rev. Inst. Med. trop. S. Paulo

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“…The findings in the South are consistent with the hypothesis of the effectiveness of the annual influenza vaccination program in the elderly, corroborating previous studies. Ferrer et al 22 observed a significant reduction in morbidity from respiratory diseases in the elderly in the State of Paraná after the annual vaccination program was introduced. Campagna et al 11 reported a persistent decrease in mortality from pneumonia, influenza, bronchitis, and upper airway obstruction in the elderly during the period with vaccination, for Brazil as a whole and especially for the South and Southeast regions.…”

Section: Discussionmentioning

confidence: 99%

Ecological study on mortality from influenza and pneumonia before and after influenza vaccination in the Northeast and South of Brazil

et al. 2013

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The study compared mortality from influenza and pneumonia in elderly people (65 years or older) before and since implementation of influenza vaccination in the South and Northeast regions of Brazil. Official population and mortality data were retrieved from government agencies to estimate weekly mortality rates. The Serfling model was used to identify influenza outbreaks and estimate the mortality attributable to them. In the South, the vaccination period showed a major reduction in mortality from influenza and pneumonia and in the number and duration of influenza outbreaks. These results were interpreted as consistent with the hypothesis of the vaccination program's effectiveness. In the Northeast, there was an increase in mortality from influenza and pneumonia during vaccination, which was associated with a quality improvement in recording causes of death in the elderly. An increase was also seen in mortality attributable to influenza outbreaks, suggesting a mismatch between the period in which vaccination is conducted and the relevant climatic characteristics for influenza transmission.

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“…A diminuição dos casos de óbito em relação à vacinação contra a Influenza e a revelação desta como fator de proteção ao óbito sugere impacto positivo do procedimento na redução da gravidade da doença. Além disso, a diminuição do número de óbitos nos pacientes com idade igual ou superior a 60 anos, conforme evidenciado pela figura 1 sugere aquisição de um efeito protetor conferido pela imunização a partir das vacinas, há anos administradas nesta camada da população, conforme discutido por outro autor (19) . Assim, esses pacientes, anteriormente reconhecidos como de maior risco para o óbito por influenza, possivelmente graças à imunidade cruzada, apresentaram neste evento pandêmico, menor número de óbitos.…”

Section: Discussionunclassified

Fatores relacionados ao óbito pela Influenza Pandêmica A (H1N1) 2009 em pacientes tratados com Oseltamivir

et al. 2013

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This study aimed to identify factors related to death in Pandemic Influenza A(H1N1)2009 in patients treated with Oseltamivir. It is an observational and retrospective study, carried out with data of patients who had presented laboratorial diagnosis of the illness. Data were collected from the notification forms of the disease, belonging to a database of the Ministry of Health. Statistical analysis was performed by chi-square, Student t test and logistic regression, considering significant p values <0,05. The highest mortality was observed in patients aged between 20 and 59 years, low schooling, with the presence of comorbidities, not vaccinated, treated late and had more severe symptoms of infection. The identification of risk factors for death reinforces the need for prevention and early care, especially in the presence of factors that increase the clinical severity of disease.

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Hospital morbidity among elderly patients, before and after influenza vaccination in the state of Paraná

Cited by 9 publications

References 10 publications

Effectiveness of the Brazilian influenza vaccination policy, a systematic review

Effectiveness of the Brazilian influenza vaccination policy, a systematic review

Ecological study on mortality from influenza and pneumonia before and after influenza vaccination in the Northeast and South of Brazil

Fatores relacionados ao óbito pela Influenza Pandêmica A (H1N1) 2009 em pacientes tratados com Oseltamivir

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