Fatores relacionados ao óbito pela Influenza Pandêmica A (H1N1) 2009 em pacientes tratados com Oseltamivir

Abstract

This study aimed to identify factors related to death in Pandemic Influenza A(H1N1)2009 in patients treated with Oseltamivir. It is an observational and retrospective study, carried out with data of patients who had presented laboratorial diagnosis of the illness. Data were collected from the notification forms of the disease, belonging to a database of the Ministry of Health. Statistical analysis was performed by chi-square, Student t test and logistic regression, considering significant p values <0,05. The highest mortality was observed in patients aged between 20 and 59 years, low schooling, with the presence of comorbidities, not vaccinated, treated late and had more severe symptoms of infection. The identification of risk factors for death reinforces the need for prevention and early care, especially in the presence of factors that increase the clinical severity of disease.

Severe acute respiratory syndrome by influenza and factors associated with death in older adults: a population study

“…Lenzi and authors reported an increased risk of death due to influenza with age [23]. In their study, for each additional year of life, the risk of death increased by 5.5%.…”

“…Regarding literacy, our study shows a higher death rate among participants with complete the first cycle of elementary school (14.8%). In contrast, Lenzi et al [23] concluded that individuals with no educational level were twice as likely to die due to influenza.…”

“…The common symptoms of respiratory syndrome, such as fever, cough and dyspnea, had an incidence of 51.6%, 69.9% and 78%, respectively, among older adults with a death outcome. According to the study by Lenzi et al [23], these symptoms increase the mortality rate, with dyspnea present in approximately 18% of deaths. These results support the findings of Rossetto and Luna [24] and Capitani et al [25], where it was reported that these symptoms were the most identified in notified cases and their records.…”

Caracterização epidemiológica da população pediátrica com síndrome respiratória aguda grave devido a infecção pelo vírus influenza no Brasil entre 2018 e 2021.

“…O óbito foi um desfecho pouco frequente atingindo 6,93% dos pacientes internados, sendo as variáveis mais relacionadas a esse encerramento a febre, desconforto respiratório e internação em UTI. Diferente do resultado encontrado, um estudo observacional e retrospectivo da pandemia de H1N1 de 2009 identificou que pacientes adultos com evolução para óbito apresentaram maior incidência de tosse (94%), seguida de dispneia (90%) e febre (89,6%) 22 . A idade não se mostrou um importante preditor entre a faixa etária pediátrica, sendo a prevalência um pouco maior em pacientes entre 2 e 3 anos de idade, ao contrário do observado em um estudo chinês no qual pacientes maiores de 3 anos tiveram uma maior evolução ao óbito 23 .…”

Fatores associados ao óbito dos casos graves de influenza A(H1N1)pdm09

“…Outro estudo no Paraná identificou maior chance de óbito nos casos hospitalizados, com comorbidades, dispneia, não vacinados contra influenza, faixa etária crescente e retardo no início do oseltamivir 24 .…”