Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s

Abstract

BackgroundOur aim is to explore the trend of association between the survival rates of colorectal cancer (CRC) and the different clinical characteristics in patients registered from 1960s to 2000s. We hypothesized that the survival rate of CRC increases over time and varies according to anatomic subsites.MethodsInformation from a total of 4558 stage T(1-4)N(1-2)M0 CRC patients registered from 1960s to 2008 were analyzed. The association of CRC overall survival with age, gender, tumor locations, time, histopathology types, pathology grades, no. of examined lymph nodes, the T stage, and the N stage was analyzed. The assessment of the influence of prognostic factors on patient survival was performed using Cox’s proportional hazard regression models.ResultsFrom 1960 to 2008, the studied CRC patients included 2625 (57.6%) and 1933 (42.4%) males and females, respectively. These included 1896 (41.6%) colon cancers, and 2662 (58.4%) rectum cancers. The 5-year survival rate was 49%, 58%, 58%, 70%, and 77% for the time duration of 1960s, 1970s, 1980s, 1990s and 2000s, respectively. An increased 5-year survival rate was observed in the colon cancer and rectum cancer patients. Patients older than 60 years of age were more likely to develop colonic cancer (sigmoid) than rectum cancer (49.2% vs. 39.9%). The Cox regression model showed that only rectum cancer survival was related to time duration.ConclusionThe overall survival and 5-year survival rates showed an increase from the 1960s to 2000s. There is a trend of rightward shift of tumor location in CRC patients.

Reevaluation of a rightward shift in colorectal cancer: A single‐center retrospective study in Tianjin

“…However, other studies have not found a trend towards an increased prevalence of RSCC . In the four Chinese studies, the results are also controversial, which might be related to differences in geography, urban development, and lifestyle …”

“…However, relevant studies are limited in Eastern populations. A few studies in Asia have suggested a proximal shift in CRC, whereas other Eastern scientists stated that no shift was found . Therefore, the right shift of CRC has not been determined in either Western or Eastern countries.…”

“…Owing to the rising incidence and mortality of CRC in China, it is crucial to ascertain whether there is a shift in the anatomic distribution of CRC occurring among Chinese patients, which may have implications for screening strategies in China. There have been several related studies published in China, but recent data from northern China are lacking. In addition, the relationship between age, sex, and CRC anatomic distribution remains unclear.…”

Cancer survival in Qidong between 1972 and 2011: A population-based analysis

“…There have been numerous reports on cancer survival revealing improvements through various therapies, derived from hospital-based datasets (1)(2)(3)(4). However, there are few reports on the general efficiency of cancer health services derived from long-term population-based cancer registration systems (5)(6)(7)(8)(9)(10).…”

Downregulating forkhead box M1 inhibits proliferation by inhibiting autophagy in the sw480 cell line

“…Colon cancer is the third most frequently diagnosed cancer and one of the leading causes of cancer-related deaths worldwide (1,2). Many studies have attempted to demonstrate its effects on tumorigenesis, however, further investigation is still required.…”