Downregulating forkhead box M1 inhibits proliferation by inhibiting autophagy in the sw480 cell line

Zhong, Shibiao; Zhou, Aiyan; Qi, Fanghua; Li, Zhen; Yu, Ze‐Yan; Lu, Yongchao; Li, Xudong

doi:10.3892/br.2017.915

Cited by 11 publications

(5 citation statements)

References 14 publications

(14 reference statements)

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“…The oncogenic potential of FOXM1 is based on its faculty to regulate the expression of target genes involved in cell cycle transition, cell proliferation, chromosome stability, stem cell renewal, and later phases of tumorigenesis. Indeed, studies aimed at FOXM1 inhibition in cancer cells have observed a decrease in cell proliferation and migration, metastasis, angiogenesis, EMT, and drug resistance, demonstrating the implication of FOXM1 in these different processes [40][41][42][43][44][45]. FOXM1 is therefore a potential therapeutic target in cancer therapy potentialy inhibited by PL.…”

Section: Discussionmentioning

confidence: 99%

Piperlongumine promotes death of retinoblastoma cancer cells

Allaman-Pillet

2021

Oncotarget

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Retinoblastoma is the most common pediatric intraocular malignant tumor. While retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene (RB1) in the developing retina, tumor progression requires additional epigenetic changes, retinoblastoma genomes being quite stable. Although the management of RB has recently improved, new therapeutic agents are necessary to improve the treatment of advanced forms of retinoblastoma. In this report, we analyzed the pro-death effect of piperlongumine (PL), a natural compound isolated from Piper longum L., on two human retinoblastoma cell lines, WERI-Rb and Y79. The effects of PL on cell proliferation, cell death and cell cycle were investigated. PL effectively inhibited cell growth, impacted the cell cycle by decreasing the level of cyclins and CDK1 and increasing CDKN1A and triggered a caspase-3 independant cell death process in which reactive oxygen species (ROS) production is a major player. Indeed, PL toxicity in retinoblastoma cell lines was inhibited by a ROS scavenger N-acetyl-l-cysteine (NAC) treatment. These findings suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle.

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Section: Discussionmentioning

confidence: 99%

Piperlongumine promotes death of retinoblastoma cancer cells

Allaman-Pillet

2021

Oncotarget

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“…FoxM1 has been reported to play an oncogenic role in colon cancer [22,23]. We investigated whether FoxM1 could be inhibited by PF in colon cancer cells.…”

Section: Pf Inhibited Foxm1 Expression In Colon Cancer Cellsmentioning

confidence: 99%

Paeoniflorin inhibits cell growth and induces cell cycle arrest through inhibition of FoxM1 in colorectal cancer cells

Yue

Yan

et al. 2018

Cell Cycle

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Paeoniflorin (PF) exhibits tumor suppressive functions in a variety of human cancers. However, the function of PF and molecular mechanism in colorectal cancer are elusive. In the present study, we investigated whether PF could exert its antiproliferative activity, anti-migration, and anti-invasive function in colorectal cancer cells. We found that PF inhibited cell growth and induced apoptosis and blocked cell cycle progression in the G0/G1 phase in colorectal cancer cells. Moreover, we found that PF suppressed cell migration and invasion in colorectal cancer cells. FoxM1 has been reported to play an important oncogenic role in human cancers. We also determine whether PF inhibited the expression of FoxM1, leading to its anti-cancer activity. We found that PF treatment in colorectal cancer cells resulted in down-regulation of FoxM1. The rescue experiments showed that overexpression of FoxM1 abrogated the tumor suppressive function induced by PF treatment. Notably, depletion of FoxM1 promoted the anti-tumor activity of PF in colorectal cancer cells. Therefore, inhibition of FoxM1 could participate in the anti-tumor activity of PF in colorectal cancer cells.

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“…2 ). Inhibition of FOXM1 in cancer cells leads to decreased cell proliferation and migration, metastasis, angiogenesis, EMT, and drug resistance [ 22 – 26 ]. Furthermore, a recent meta-analysis revealed that elevated FOXM1 expression is related to poor prognosis in most solid tumors [ 27 ], which is also further confirmed by the TCGA database (Fig.…”

Section: Introductionmentioning

confidence: 99%

Regulation of the master regulator FOXM1 in cancer

et al. 2018

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FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients. FOXM1 maintains cancer hallmarks by regulating the expression of target genes at the transcriptional level. Due to its potential role as molecular target in cancer therapy, FOXM1 was named the Molecule of the Year in 2010. However, the mechanism of FOXM1 dysregulation remains indistinct. A comprehensive understanding of FOXM1 regulation will provide novel insight for cancer and other diseases in which FOXM1 plays a major role. Here, we summarize the transcriptional regulation, post-transcriptional regulation and post-translational modifications of FOXM1, which will provide extremely important implications for novel strategies targeting FOXM1.

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Downregulating forkhead box M1 inhibits proliferation by inhibiting autophagy in the sw480 cell line

Cited by 11 publications

References 14 publications

Piperlongumine promotes death of retinoblastoma cancer cells

Piperlongumine promotes death of retinoblastoma cancer cells

Paeoniflorin inhibits cell growth and induces cell cycle arrest through inhibition of FoxM1 in colorectal cancer cells

Regulation of the master regulator FOXM1 in cancer

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