Horned Melon (Cucumis metuliferus E. Meyer Ex. Naudin)—Current Knowledge on Its Phytochemicals, Biological Benefits, and Potential Applications

Šeregelj, Vanja; Šovljanski, Olja; Šaponjac, Vesna Tumbas; Vulić, Jelena; Ćetković, Gordana; Markov, Siniša; Čanadanović-Brunet, Jasna

doi:10.3390/pr10010094

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…Although the predictive capabilities of the ANN modeling technique have been tested on different antimicrobial potential setups [ 26 , 27 , 28 , 53 , 54 ], this study enables the explication of the antiadhesion and antibiofilm-forming characteristics of mushroom extracts for the first time. The targeted physiological characteristics of bacterial cells relevant to the decreasing of food-borne infection have been observed by modest, routine, and repeatable assays.…”

Section: Discussionmentioning

confidence: 99%

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

et al. 2023

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The problem of microbial biofilms has come to the fore alongside food, pharmaceutical, and healthcare industrialization. The development of new antibiofilm products has become urgent, but it includes bioprospecting and is time and money-consuming. Contemporary efforts are directed at the pursuit of effective compounds of natural origin, also known as “green” agents. Mushrooms appear to be a possible new source of antibiofilm compounds, as has been demonstrated recently. The existing modeling methods are directed toward predicting bacterial biofilm formation, not in the presence of antibiofilm materials. Moreover, the modeling is almost exclusively targeted at biofilms in healthcare, while modeling related to the food industry remains under-researched. The present study applied an Artificial Neural Network (ANN) model to analyze the anti-adhesion and anti-biofilm-forming effects of 40 extracts from 20 mushroom species against two very important food-borne bacterial species for food and food-related industries—Listeria monocytogenes and Salmonella enteritidis. The models developed in this study exhibited high prediction quality, as indicated by high r2 values during the training cycle. The best fit between the modeled and measured values was observed for the inhibition of adhesion. This study provides a valuable contribution to the field, supporting industrial settings during the initial stage of biofilm formation, when these communities are the most vulnerable, and promoting innovative and improved safety management.

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Section: Discussionmentioning

confidence: 99%

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

et al. 2023

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“…Cucurbitaceae Cucumis metuliferus ⁑ Native Tropical and subtropical Sub-Saharan regions of Africa [91] Well studied elsewhere [100] Fruits (pulp, peel and seeds)…”

Section: Leaves and Flowersmentioning

confidence: 99%

The Status of Vegetables Research in Malawi, Capacity, Progress, Gaps, and Way Forward—A Scoping Review

Mazibuko¹,

Okazawa²,

Gono³

et al. 2023

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Vegetables are key to nutrition and economic security, especially for developing societies. Research in vegetables has been historically key. From early domestication efforts to modern-day breeding and value addition, research has enabled vegetable productivity to support the nutritional and economic needs of societies. Impactful research, however, requires competent research capacity and a guiding framework, in a continuously changing socio-climatic world. Vegetable research appraisal in Malawi, especially regarding capacity, focus, and a guiding framework, is lacking.

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“…The fruit of C. metuliferus has a wide list of health benefits due to its varied phytochemical composition. The pulp contains considerable amounts of β-carotene, vitamin A, and vitamin C, which are very important for strengthening the immune system, night vision, or the curative effect of the skin [23,24]. In addition, a wide range of other secondary metabolites has been identified, such as glycosides, alkaloids, flavonoids, saponins, steroids, tannins, and terpenoids [25].…”

Section: Introductionmentioning

confidence: 99%

Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

et al. 2023

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To identify healthy, nutritious, and sustainable plant-based products rich in biologically active compounds, this present study was conducted, and the phytochemical composition and biological properties of the hydroethanolic ultrasound-assisted extract of the fruits of Cucumis metuliferus were investigated. Cucumis metuliferus is an unexplored fruit of a climbing plant in the Cucurbitaceae family, widely distributed in the tropical and subtropical regions of sub-Saharan Africa and whose nutritional and medicinal benefits are well known in African countries, especially. Therefore, its cultivation in other regions could influence chemical composition. The structural identification of the compounds from the hydroethanolic extract from Cucumis metuliferus fruits grown in Romania was carried out by chromatographic techniques (HPLC). The main compounds identified were catechin, oleanolic acid, ursolic acid, p-coumaric acid, and epicatechin. Subsequently, a method was proposed to isolate and characterize ursolic acid, one of the major compounds. The obtained results show that the hydroethanolic extract is rich in antioxidant compounds evaluated using the DPPH radical inhibition method (IC50 = 32.74 ± 0.02 µg/mL) and ABTS cation radical inhibition method (IC50 = 11.37 ± 0.07 µg/mL). It also demonstrate in vitro anti-inflammatory activities, such as anti-lipoxygenase (IC50 = 32.90 ± 0.05 µg/mL) and anti-proteinase (IC50 = 16.34 ± 0.07 µg/mL), and antidiabetic properties by inhibiting α-amylase (IC50 = 429.541 ± 0.25 µg/mL) and β-glucosidase activity (IC50 = 385.685 ± 0.76 µg/mL). Therefore, C. metuliferus fruits could be effectively used in the development of various health-promoting products, being not only appetizing, with spectacular appearance and with extended storage life, but also curative and healthy.

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Horned Melon (Cucumis metuliferus E. Meyer Ex. Naudin)—Current Knowledge on Its Phytochemicals, Biological Benefits, and Potential Applications

Cited by 9 publications

References 46 publications

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

The Status of Vegetables Research in Malawi, Capacity, Progress, Gaps, and Way Forward—A Scoping Review

Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

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