Hormones in Lymph Leaving Endocrine Glands

Czeizel, E; M, Hancsok; Palkovich, I

doi:10.1016/s0140-6736(63)93102-7

Cited by 4 publications

(3 citation statements)

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“…Early studies from the 1920s to the 1960s documented the existence of the lymphatics in the CL of other large animals (cow, ewe, pig, and dog) 19,23,39,40 using early histological techniques (e.g., injection of Indian ink). It will be important to re-evaluate the ovarian compartments of various species using modern molecular markers for LECs to provide clearer localization of lymphatics and characterization of luteal LECs.…”

Section: Lymphatics In Primate CLmentioning

confidence: 99%

“…Early morphologic studies revealed that a profuse network of lymphatic vessels, which vary greatly in size during the different stages of the estrous cycle, exists in the CL of domestic animals 19,20 as well as the rabbit and dog. [21][22][23] In contrast, the small CL of rodents was reported as virtually devoid of lymphatics. 24 However, to date there are no detailed reports on the lymphatics in the primate CL.…”

Section: Introductionmentioning

confidence: 99%

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Existence of the Lymphatic System in the Primate Corpus Luteum.

Stouffer

2008

Biology of Reproduction

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To date, there have been no detailed studies on the lymphatic system in the primate corpus luteum (CL); early reports suggested that the presence of this ''secondary circulation'' in luteal tissue is species-dependant. Therefore, studies were designed to determine if (a) lymphatic vessels exist, and (b) recently discovered lymphangiogenic factors and their receptor are expressed in the macaque CL during the menstrual cycle. Immunohistochemistry (IHC) detected the lymphatic endothelial cell marker, lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), in some endothelial cells and vessels within the ovarian stroma and theca layer of preovulatory follicles and in the CL. Dual fluorescent IHC demonstrated that LYVE1 co-localized with another lymphatic endothelial cell marker D2-40, but a blood vascular endothelial cell marker (von Willebrand Factor, VWF) was in different cells. The numbers and staining intensity of LYVE1-positive cells in the CL appeared to increase from early to mid luteal phase, and remained elevated thereafter. RT-PCR detected cDNA fragments for mRNAs encoding VEGFC, FIGF, and their receptor FLT4 in CL. Real-time PCR analyses revealed similar patterns of VEGFC and FLT4 expression during the luteal lifespan; mRNA levels increased (p < 0.05) from early to mid luteal phase and decreased (p < 0.05) by late luteal phase. In contrast, FIGF levels were elevated initially, declined (p < 0.05) at mid luteal phase, and then increased (p < 0.05) to very late luteal phase. The data strongly suggest that lymphatic vessels are present in the primate CL, and that the VEGFC=FIGF-FLT4 system regulates lymphangiogenesis and luteal structure-function during the menstrual cycle.

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Section: Lymphatics In Primate CLmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Existence of the Lymphatic System in the Primate Corpus Luteum.

Stouffer

2008

Biology of Reproduction

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“…2 In his next paper, "Effects of Influenza on Pregnancy," published in 1967, 3 he adopted the first name Andrew-the anglicized version of Endre. In 1972 the first of his many letters and papers published in The BMJ was signed "A Czeizel."…”

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confidence: 99%