Hormones Controlling Homeostasis in Insects

Schooley, David A.; Horodyski, Frank M.; Coast, Geoffrey M.

doi:10.1016/b978-0-12-809633-8.04033-4

Cited by 6 publications

(8 citation statements)

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“…Orchestration of physiological and behavioral processes is commonly dependent on neuropeptide and peptide hormone signaling (see [ 1 – 4 ]). For example, feeding and postprandial effects on the organism, including satiety, nutrient and energy reallocation, diuresis, and activity/sleep are regulated by multiple peptides (see [ 1 , 3 , 5 – 9 ]). Thus, in Drosophila melanogaster, several neuropeptides such as allatostatin A, neuropeptide F, short neuropeptide F (sNPF), sulfakinin, and hugin-pyrokinin are known to regulate feeding, and five peptides, diuretic hormones 31 and 44, leucokinin as well as CAPA-1 and 2, derived from the gene capability , regulate ion and water homeostasis (see [ 1 , 3 , 7 , 10 – 13 ]).…”

Section: Introductionmentioning

confidence: 99%

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Zandawala

Marley

Davies

et al. 2017

Cell. Mol. Life Sci.

133

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Multiple neuropeptides are known to regulate water and ion balance in Drosophila melanogaster. Several of these peptides also have other functions in physiology and behavior. Examples are corticotropin-releasing factor-like diuretic hormone (diuretic hormone 44; DH44) and leucokinin (LK), both of which induce fluid secretion by Malpighian tubules (MTs), but also regulate stress responses, feeding, circadian activity and other behaviors. Here, we investigated the functional relations between the LK and DH44 signaling systems. DH44 and LK peptides are only colocalized in a set of abdominal neurosecretory cells (ABLKs). Targeted knockdown of each of these peptides in ABLKs leads to increased resistance to desiccation, starvation and ionic stress. Food ingestion is diminished by knockdown of DH44, but not LK, and water retention is increased by LK knockdown only. Thus, the two colocalized peptides display similar systemic actions, but differ with respect to regulation of feeding and body water retention. We also demonstrated that DH44 and LK have additive effects on fluid secretion by MTs. It is likely that the colocalized peptides are coreleased from ABLKs into the circulation and act on the tubules where they target different cell types and signaling systems to regulate diuresis and stress tolerance. Additional targets seem to be specific for each of the two peptides and subserve regulation of feeding and water retention. Our data suggest that the ABLKs and hormonal actions are sufficient for many of the known DH44 and LK functions, and that the remaining neurons in the CNS play other functional roles.Electronic supplementary materialThe online version of this article (doi:10.1007/s00018-017-2682-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Zandawala

Marley

Davies

et al. 2017

Cell. Mol. Life Sci.

133

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“…Insect osmoregulation, that is, the regulation of cellular ion and water homeostasis via transporters and water channels, is subject to highly sophisticated endocrine control. 22 In D. melanogaster, several families of neuropeptides have been identified that regulate diuresis in the MTs, including the diuretic hormones DH 31 23 and DH 44 , 24 the Capability (Capa)-related peptides 25 and the leucokinin (LK) neuropeptide. 26 The recent transcriptomics and peptidomic analyses of the neuropeptides and their cognate receptors in D. suzukii have allowed identification of orthologous peptides and receptors, which in turn facilitates functional studies to identify suitable targets for the development of novel control strategies against this invasive pest.…”

Section: Introductionmentioning

confidence: 99%

Renal neuroendocrine control of desiccation and cold tolerance byDrosophila suzukii

Terhzaz

Alford

Yeoh

et al. 2017

Pest Management Science

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BACKGROUNDNeuropeptides are central to the regulation of physiological and behavioural processes in insects, directly impacting cold and desiccation survival. However, little is known about the control mechanisms governing these responses in Drosophila suzukii. The close phylogenetic relationship of D. suzukii with Drosophila melanogaster allows, through genomic and functional studies, an insight into the mechanisms directing stress tolerance in D. suzukii.RESULTSCapability (Capa), leucokinin (LK), diuretic hormone 44 (DH44) and DH31 neuropeptides demonstrated a high level of conservation between D. suzukii and D. melanogaster with respect to peptide sequences, neuronal expression, receptor localisation, and diuretic function in the Malpighian tubules. Despite D. suzukii's ability to populate cold environments, it proved sensitive to both cold and desiccation. Furthermore, in D. suzukii, Capa acts as a desiccation‐ and cold stress‐responsive gene, while DH 44 gene expression is increased only after desiccation exposure, and the LK gene after nonlethal cold stress recovery.CONCLUSIONThis study provides a comparative investigation into stress tolerance mediation by neuroendocrine signalling in two Drosophila species, providing evidence that similar signalling pathways control fluid secretion in the Malpighian tubules. Identifying processes governing specific environmental stresses affecting D. suzukii could lead to the development of targeted integrated management strategies to control insect pest populations. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…In addition, the silkworm is an economically important insect, being a primary producer of silk, and meanwhile, as a model of Lepidoptera, the silkworm could serve as a good system for investigation of signaling and physiological functions of the CAPA peptide/receptor system. Thus, identification of the cognate receptors for Bombyx CAPA-PVKs by using a reverse physiological approach will pave the way to elucidate the possible roles in the regulation of insect fluid homeostasis, cardioacceleratory effect, developmental processes, feeding, mating, and behavior (4,(33)(34)(35).…”

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confidence: 99%

BNGR-A25L and -A27 are two functional G protein–coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori

Shen¹,

Chen²,

Hong

et al. 2017

Journal of Biological Chemistry

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CAPA peptides, such as periviscerokinin (PVK), are insect neuropeptides involved in many signaling pathways controlling, for example, metabolism, behavior, and reproduction. They are present in a large number of insects and, together with their cognate receptors, are important for research into approaches for improving insect control. However, the CAPA receptors in the silkworm () insect model are unknown. Here, we cloned cDNAs of two putative CAPA peptide receptor genes, BNGR-A27 and -A25, from the brain of larvae. We found that the predicted BNGR-A27 ORF encodes 450 amino acids and that one BNGR-A25 splice variant encodes a full-length isoform (BNGR-A25L) of 418 amino acid residues and another a short isoform (BNGR-A25S) of 341 amino acids with a truncated C-terminal tail. Functional assays indicated that both BNGR-A25L and -A27 are activated by the PVK neuropeptides-CAPA-PVK-1 and -PVK-2, leading to a significant increase in cAMP-response element-controlled luciferase activity and Ca mobilization in a G inhibitor-sensitive manner. In contrast, BNGR-A25S was not significantly activated in response to the PVK peptides. Moreover, -CAPA-PVK-1 directly bound to BNGR-A25L and -A27, but not BNGR-A25S. Of note, CAPA-PVK-mediated ERK1/2 phosphorylation and receptor internalization confirmed that BNGR-A25L and -A27 are two canonical receptors for CAPA-PVKs. However, BNGR-A25S alone is a nonfunctional receptor but serves as a dominant-negative protein for BNGR-A25L. These results provide evidence that BNGR-A25L and -A27 are two functional G-coupled receptors for CAPA-PVKs, enabling the further elucidation of the endocrinological roles of-CAPA-PVKs and their receptors in insect biology.

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Hormones Controlling Homeostasis in Insects

Cited by 6 publications

References 500 publications

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Renal neuroendocrine control of desiccation and cold tolerance byDrosophila suzukii

BNGR-A25L and -A27 are two functional G protein–coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori

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