2017
DOI: 10.1007/s00018-017-2682-y
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Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Abstract: Multiple neuropeptides are known to regulate water and ion balance in Drosophila melanogaster. Several of these peptides also have other functions in physiology and behavior. Examples are corticotropin-releasing factor-like diuretic hormone (diuretic hormone 44; DH44) and leucokinin (LK), both of which induce fluid secretion by Malpighian tubules (MTs), but also regulate stress responses, feeding, circadian activity and other behaviors. Here, we investigated the functional relations between the LK and DH44 sig… Show more

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Cited by 61 publications
(137 citation statements)
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References 58 publications
(94 reference statements)
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“…Previously, we showed that systemic Crz signaling modulates feeding and nutritional stress through direct actions on the fat body as well as via interactions with AKH and insulinsignaling [9]. Since CrzR is highly expressed in the CNS (Figure S1), we hypothesized that 12 Crz may interact with other peptidergic signaling to maintain physiological homeostasis associated with stress. To test this assumption, we mapped the distribution of CrzR expression in adult CNS by using different CrzR-GAL4 lines to drive GFP expression.…”
Section: Crzr Is Expressed In Capa Neuronsmentioning
confidence: 97%
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“…Previously, we showed that systemic Crz signaling modulates feeding and nutritional stress through direct actions on the fat body as well as via interactions with AKH and insulinsignaling [9]. Since CrzR is highly expressed in the CNS (Figure S1), we hypothesized that 12 Crz may interact with other peptidergic signaling to maintain physiological homeostasis associated with stress. To test this assumption, we mapped the distribution of CrzR expression in adult CNS by using different CrzR-GAL4 lines to drive GFP expression.…”
Section: Crzr Is Expressed In Capa Neuronsmentioning
confidence: 97%
“…Immunohistochemistry for D. melanogaster adult CNS and gut was performed as described earlier [12]. Briefly, tissues were dissected in phosphate buffered saline (PBS), fixed in 5% ice-cold paraformaldehyde (3.5 -4 hours), washed in PBS and incubated in primary antibodies ( Table 2) diluted in PBS with 0.5% Triton X (PBST) for 48 hours at 4°C.…”
Section: Immunohistochemistry and Imagingmentioning
confidence: 99%
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“…Insect kinins are multifunctional neuropeptides which share a conserved C-terminal pentapeptide motif Phe-X 1 -X 2 -Trp-Gly-NH2, where X 1 can be His, Asn, Ser or Tyr, and X 2 can be Ser, Pro or Ala. 6 The insect kinins have been identified in most insects, with the exception of Coleoptera, 7 and have diverse roles in the stimulation of muscle, 8 fluid secretion in renal tubules, 9,10 digestive enzyme release, 11 inhibition of larval weight gain 12 and the desiccation and starvation stress response. 13,14 The second family, the CAPA peptides, were first identified from the moth Manduca sexta (CAP2b) 15 and have since been identified in many insect families. 16 Although function varies depending on insect species, life stage, and lifestyle, CAPA peptides play a key role in myomodulation and osmoregulation 16 and have more recently been linked to desiccation and cold tolerance in Drosophila species.…”
Section: Introductionmentioning
confidence: 99%