Hormones and cervical ripening: Dehydroepiandrosterone sulfate, estradiol, estriol, and progesterone

Zuidema, Laura J.; Khan-Dawood, Firyal S.; Dawood, M. Yusoff; Work, Bruce A.

doi:10.1016/0002-9378(86)90154-7

Cited by 22 publications

(12 citation statements)

References 14 publications

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“…In contrast to observations just before the induction of labod 24 , progesterone significantly differed in women with a modified Bishop score of < 4 and > 4, respectively, at the calculated term. Progesterone was the only hormone which strongly correlated with the Bishop score in an inverse way, similar to ripening effects previously discussed for guinea pigs 1 .…”

Section: Discussioncontrasting

confidence: 97%

Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Eppel

Kucera

Bieglmayer

1999

BJOG

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Objective To assess whether cervical size in the early second trimester and cervical ripening at term may be related to serum levels of endogenous relaxin, 17R-oestradiol or progesterone.Design A cross-sectional study investigating the relationship between hormone concentrations and cervical parameters as measured by ultrasound and Bishop score, respectively.Participants Uncomplicated human pregnancies with normal fetal outcome, 72 women in the second trimester and 40 women at term.Methods Vaginal ultrasound and palpation were used to estimate cervical parameters. Hormones were analysed either by dissociation-enhanced fluoroimmunoassay (relaxin) or by automated electrochemiluminescent immunoassays.Results Cervical length and diameter correlated positively during mid-gestation and negatively at term. During mid-gestation, but not at term, relaxin was significantly associated with cervical length and volume, and with progesterone. Bishop score only correlated inversely with progesterone at term.Conclusion Corpus luteum function is reflected by progesterone and relaxin in the early second trimester. An impact of relaxin on cervical growth, previously demonstrated by animal models and in v i m experiments, was confirmed during human mid-gestation. In contrast to many other species, human cervical ripening was not associated with endogenous relaxin at term, but with decreased progesterone.

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Section: Discussioncontrasting

confidence: 97%

Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Eppel

Kucera

Bieglmayer

1999

BJOG

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“…suppressed E3 levels. The peak levels of DHAS and Er as well as other ste roids of adrenal or placental origin at admission to the delivery room reflect increased maternal and fetal stress with the onset of labor [32], In pregnancy, biosynthesis and secretion of DHAS and E3 as the main secretory products of the fetoplacental unit are very closely correlated. The correct interpretation of lowered or increased maternal DHAS and E3 levels, there fore depends on knowledge of the physiological changes of these hormones throughout gestation obtained longitudi nally from a carefully selected group of normal pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Concentrations of Dehydroepiandrosterone Sulfate and Estriol in Maternal Plasma during Pregnancy: A Longitudinal Study in Healthy Women throughout Gestation and at Term

Peter

Dörr²,

Sippell

1994

Horm Res

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In a longitudinal study, the changes in plasma concentrations of dehydroepiandrosterone sulfate (DHAS) and total estriol (E₃) were followed in 10 normal pregnant women throughout gestation at 8-10, 14-17,21-24,28-32, and 38 weeks as well as at the time of admission to the delivery room. The mean plasma concentration of DHAS decreased from 325 ± 38.2 μg/dl in early gestation to minimum levels of 120 ± 15.9 μg/dl at week 38. At delivery there was a 2-fold increase in plasma DHAS (205.3 ± 17.7 μg/dl). The mean total E₃plasma concentration increased from 6.53 ± 2.5 ng/ml at week 8-10 to 198.6 ± 30.3 ng/ml prior to delivery. The decrease in the DHAS plasma levels is caused by the elevated metabolic clearance rate throughout pregnancy. The increasing E₃ plasma levels are caused by increasing steroid production by the fetoplacental unit and reflect fetal well-being. The peak levels of DHAS and E₃as well as of other steroids of adrenal or placental origin at admission to the delivery room reflect increased maternal and fetal stress with the onset of labor. These longitudinal reference data determined by modern radioimmunoassay methodology are helpful for the prenatal diagnosis of congenital disorders with insufficient or absent fetoplacental function, and in the control of suppression of the fetal pituitary-adrenal axis during dexamethasone treatment in pregnancies with a female fetus affected with congenital adrenal hyperplasia.

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“…Although these steroids are the precursors for estradiol and estriol, respectively, and allow placental production of estrogens, they are not inactive. However, a ripening cervix has been associated with an increase in circulating maternal DHA sulfate (222), indicating that a substantial proportion of DHA from the fetal adrenal has avoided aromatization by the placenta. IL-2 has a modest inhibitory effect on amnion PG synthesis (219) but might have an indirect stimulatory effect by acting on leukocytederived cells.…”

Section: Kellymentioning

confidence: 99%

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

Kelly

1994

Endocrine Reviews

153

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Hormones and cervical ripening: Dehydroepiandrosterone sulfate, estradiol, estriol, and progesterone

Cited by 22 publications

References 14 publications

Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Changes in the Concentrations of Dehydroepiandrosterone Sulfate and Estriol in Maternal Plasma during Pregnancy: A Longitudinal Study in Healthy Women throughout Gestation and at Term

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

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