Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Eppel, Wolfgang; Kucera, E; Bieglmayer, C.

doi:10.1111/j.1471-0528.1999.tb08430.x

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…It can be assumed that the low level of relaxin in the group of pregnant women with immature uterine inhibited the process of cervical dilatation. Considering the mechanisms of the possible influence of relaxin on the state of the birth canal readiness, one can note its ability to change the activity of matrix metalloproteinases that control the structure of glycoproteins in the extracellular matrix [8,13,15].…”

Section: Research Resultsmentioning

confidence: 99%

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The levels of relaxin and amino acids play a critical role in women with variable degree of preparedness for labour

Shcherbina

Shelest

2021

Eureka: HS

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Underlying biochemical factors that contribute towards the preparedness for labour and ripening of the cervix remain largely unknown. We aimed to characterize metabolic and hormonal determinants that constitute the preparedness for labour in women. The aim of the research was to study the content of relaxin and amino acids involved in its formation in primiparous pregnant women with various degrees of birth preparedness. Materials and methods: Prospective study has been conducted on 115 primiparous women at 38-40 weeks of gestation. Biochemical methods were used to analyse relaxin and amino acid levels in pregnant women with varying degree of birth preparedness. Results: the obtained data from the study indicate importance role of relaxin in the underlying pathogenesis in women with variable degree of preparedness for labour. The results allow to use the levels of relaxin serum as a predictor of the state of the birth canal. Furthermore, the amino acids are known to participate in various critical metabolic processes and play an important role is orchestrating many essential pathways in the body. We present the analysis of amino acids involved in the formation of relaxin in the serum of pregnant women. Our analysis has shown that amino acid imbalance leads to disruption of energy metabolism and blood flow rate, resulting in metabolic, structural and functional changes in the cervix at the onset of labour. Conclusion: considering the mechanisms of the possible influence of relaxin and amino acids on the cervical ripening, we concluded that correcting amino acid imbalance and normalising relaxin levels should be included in preinduction of labour therapeutic regimen. This would be an important step in improving the perinatal outcomes

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Section: Research Resultsmentioning

confidence: 99%

“…Relaxin is an important participant in many biological processes at all stages of pregnancy. Moreover, both its deficiency and excess can have negative consequences for pregnancy [12,13].…”

Section: Medicine and Dentistrymentioning

confidence: 99%

The levels of relaxin and amino acids play a critical role in women with variable degree of preparedness for labour

Shcherbina

Shelest

2021

Eureka: HS

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“…Although reports regarding the association between endogenous circulating relaxin levels and cervical ripening in women have generally shown a lack of correlation [13–17], relaxin binding sites are detected in the human cervix [18] and relaxin increases the expression of matrix metalloproteinases and glycosaminoglycans in cultured human cervical cells [19]. …”

Section: Introductionmentioning

confidence: 99%

Recombinant human relaxin versus placebo for cervical ripening: a double-blind randomised trial in pregnant women scheduled for induction of labour

Weiss

Teichman²,

Stewart³

et al. 2016

BMC Pregnancy Childbirth

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BackgroundNonclinical studies indicate that the hormone relaxin is a good candidate for a safe cervical ripening agent that does not cause uterine contractions.MethodsThis Phase II study (conducted November 2, 2005–October 20, 2006) was a randomised, double blind, placebo controlled trial testing 24-h intravenous infusion of serelaxin (recombinant human relaxin) or placebo for cervical ripening in 72 healthy, primiparous women. Eligible subjects had a singleton pregnancy ≥40 weeks, were planned for elective induction, had vertex presentation of the fetus, intact membranes and a Bishop score at screening ≤4. In Part A of the study, safety evaluation of three escalating doses of serelaxin (7.5, 25 or 75 μg/kg/day) or placebo was performed in 22 subjects admitted to the hospital 24 h prior to scheduled induction (n = 7, 4, 4, and 7 subjects, respectively). The highest safe dose from Part A and placebo were then tested in Part B for safety and cervical ripening (n = 25 subjects/arm). Planned randomisation ratio was of 4:2 (serelaxin:placebo) for each dose group in Part A and 1:1 for Part B. For analysis, subjects in Part B were pooled with those receiving the same dose in Part A and all subjects receiving placebo were pooled. The primary efficacy endpoint was change from baseline in Bishop score at 6, 12 and 24 h or end of study drug administration. Maternal safety evaluations included adverse events and vital signs through 4 weeks. Fetal assessments included serial heart rate monitoring and nonstress testing. Neonatal assessments included Apgar scores, NICU admissions, and adverse events through 4 weeks.ResultsOverall, 74 subjects were randomized and 72 were treated. There were no significant differences between the groups receiving the highest safe dose of serelaxin (75 μg/kg/day) and placebo in the primary or secondary efficacy endpoints. Changes from baseline in Bishop score at 24 h were 4.19 ± 1.9 and 3.26 ± 2.26 in the pooled placebo and serelaxin groups, respectively (p = 0.2507). Serelaxin was well tolerated and no anti-serelaxin antibodies were detected in either subjects or neonates.ConclusionSerelaxin infusion at the end of pregnancy was well tolerated but did not advance cervical ripening.Trial registrationClinicaltrials.gov identifier NCT00259103 (15 November 2005).

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Human relaxin-2: historical perspectives and role in cancer biology

et al. 2012

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One of the most recognised and studied family of peptide hormones is the insulin superfamily. Within this family is the relaxin subfamily which comprises seven members: relaxin-1, -2 and -3 and insulin-like peptides 3, 4, 5 and 6. Besides exhibiting sequence similarities, each member exists as an active A-B heterodimer linked by three disulfide bonds. This mini-review is divided into three broad themes: an overview of all insulin superfamily members (including structural similarities); roles of each superfamily member and finally, a focus on the pleiotropic peptide hormone, human relaxin-2. In addition to promoting vasodilatory effects leading to evaluation in Phase III clinical trials for the treatment of acute heart failure, relaxin has recently been shown to be highly expressed by cancer cells, aiding in their proliferation, invasiveness and metastasis. These contrary effects of relaxin are discussed together with current efforts in the development of relaxin antagonists that may possess future therapeutic potential for the treatment of certain cancers.

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Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

Cited by 7 publications

References 28 publications

The levels of relaxin and amino acids play a critical role in women with variable degree of preparedness for labour

The levels of relaxin and amino acids play a critical role in women with variable degree of preparedness for labour

Recombinant human relaxin versus placebo for cervical ripening: a double-blind randomised trial in pregnant women scheduled for induction of labour

Human relaxin-2: historical perspectives and role in cancer biology

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