Hormone Signaling Pathways in the Postnatal Mammary Gland

Monteiro, Fátima Liliana; Direito, Inês; Helguero, Luísa A.

doi:10.1007/978-3-030-44436-5_10

Cited by 2 publications

(2 citation statements)

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“…Many reviews have addressed in detail the different stages of the mammary gland (MG) development [42][43][44], and many others have focused in the role of progesterone (Pg) and PR in the normal and neoplastic MG [45][46][47][48][49][50][51][52][53]. Briefly, the MG develops after birth to generate a rudimentary duct tree.…”

Section: Pr and Mammary Gland Developmentmentioning

confidence: 99%

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Progesterone receptors in normal breast development and breast cancer

Giulianelli

Lamb

Lanari

2021

Essays in Biochemistry

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Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.

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Section: Pr and Mammary Gland Developmentmentioning

confidence: 99%

“…This process will culminate ultimately in the amplification of alveolar progenitor cells to form the lobuloalveolar units [54]. As a result, Pg reshapes gene expression through genomic and epigenomic [55][56][57][58][59] mechanisms (reviewed in [43]).…”

Section: Pr and Mammary Gland Developmentmentioning

confidence: 99%